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Factor I (FI) is the major complement inhibitor that degrades activated complement components C3b and C4b in the presence of specific cofactors. Complete FI deficiency results in secondary complement deficiency due to uncontrolled spontaneous alternative pathway activation. In this study we describe two unrelated patients with complete FI deficiency and undetectable alternative complement pathway
Unlike most ordered molecular systems, globular proteins exhibit a temperature of maximum stability, implying that the structure can be disrupted by cooling. This cold denaturation phenomenon is usually linked to the temperature-dependent hydrophobic driving force for protein folding. Yet, despite the key role played by protein−water interactions, hydration changes during cold denaturation have no
This article deals with the legal understanding of the demands in working life on employees’ability to cooperate. The concept of cooperation ability is here used in the sense of an ability to actively facilitate communication and foster relationships with colleagues and supervisors through flexibility and commitment, and thereby benefit the employer’s business. Special attention is paid to the dis
This paper presents a multimode soft-output multiple-input multiple-output (MIMO) signal detector that is efficient in hardware cost and energy consumption. The detector is capable of dealing with spatial-multiplexing (SM),break space-division-multiple-access (SDMA), and spatial-diversity (SD) signals of 4 ✕ 4 antenna and 64-QAM modulation. Implementation-friendly algorithms, which reuse most of t
The incidence of invasive group B streptococcus (GBS) infections in non-pregnant adults is increasing. Little is known about GBS in periprosthetic joint infections (PJIs). We aimed to analyse the clinical presentation of GBS PJI and its treatment in association with the outcome. The characteristics of 36 GBS PJIs collected from 10 centres were investigated. In 34 episodes, follow-up examination of
Cooking over open fire with solid fuels results in incomplete combustion and indoor air pollution (IAP) causing respiratory and other diseases leading to nearly two million premature deaths per year. In urban areas, IAP interacts with outdoor pollutants in toxic chemical mixtures affecting also other citizens and damaging regional air quality in terms of 'brown clouds'. Deaths result mainly in wom
The gamma p -> pi(0)pi(0) p reaction has been measured from threshold to 1.4 GeV using the Crystal Ball and TAPS photon spectrometers together with the photon tagging facility at the Mainz Microtron. The experimental results include total and differential cross sections as well as specific angular distributions, which were used to extract partial-wave amplitudes. In particular, the energy region b
Breast cancer is the most common cancer among women worldwide with approximately 1.150.000 new cases each year and accounting for over 400.000 deaths per year. The main cause of death for women with breast cancer is secondary tumors. Downregulation of Wnt5a in primary ductal breast cancer has been correlated with poor outcome and higher tumor grade and found to be an independent predictor of recu
Aims. The aims of this study were to: (1) compare older people care nursing staff's perceptions of their competence, work strain and work satisfaction in nursing homes and home-based care; and (2) to examine determinants of work satisfaction in both care settings. Background. The shift in older people care from hospitals to community-based facilities and home care has had implications for nursing
It is now increasingly recognized that aviation is an important driver of individual and global mobility. Growth in mobility is not evenly distributed, however: recent studies indicate that a relatively small, highly mobile part of society may account for a large share of the total distances travelled. In reviewing one of the processes that may lead to growth in individual aeromobility, the paper
Under 1800-talet tilltog de antikatolska stämningarna i Europa. Antikatolicismen hämtade sin näring från katolska kyrkans fördömande av såväl protestantismen som den moderna utvecklingen i riktning mot ett sekulärt samhälle. I flera länder utmynnade dessa motsättningar i veritabla sammandrabbningar mellan katolska kyrkan och den av liberala krafter dominerande statsmakten. Man talade om ”kulturkamIn Sweden, as in other Protestant countries, the gradual dismantling of the legislation on com-pulsory religious adherence saw the politicization of religious issues. In this situation, the imagery of the old enemy took on new functions. This was very much the case with the notion of the ‘Catholic danger’, which time and again surfaced in the Swedish media and in parlia-mentary debate. In the 1860
Control systems are often built using visual dataflow-based languages, and supporting different variants may be challenging. We introduce the concept of connection interception based on inheritance. This mechanism allows a diagram to extend another diagram and intercept connections defined in the supertype, that is, to replace it by two other connections, in order to specialize the behavior. This
Rotational coherent anti-Stokes Raman spectroscopy (CARS) in fuel-rich hydrocarbon flames, with a large content of hydrogen in the product gases (similar to 20%), has in previous work shown that evaluated temperatures are raised several tens of Kelvin by taking newly derived N-2-H-2 Raman line widths into account. To validate these results, in this work calibrated temperature measurements at aroun
Many façades made with thin rendering on thermal insulation have problems with biological growth. In this study surface temperature and surface RH were monitored over a 20 month period on test house façades with different constructions (thermal inertia), surface color and compass directions. This data were used to test three theoretical indices of biological growth with the aim of indicating the p
Rättsfallskommentar - EU-domstolens domar under år 2010 på den direkta beskattningens område
In this work a low power 5th order chebyshev active-RC low pass filter that meets Rel-8 LTE receiver requirements has been designed with programmable bandwidth and overshoot. Designed for a homodyne LTE receiver, filter bandwidths from 700kHz to 10MHz are supported. The bandwidth of the operational amplifiers is improved using a novel phase enhancement technique. The filter was implemented in 65nm
Background: Swedish nursing homes (NH) have limited capacity. As a result elderly people living in NH represent the part of the elderly population in most need of care. In Sweden a General Practitioner (GP) is usually responsible for the medical care of all subjects living in a NH. The residents in NH seldom have adequate pharmacological treatment according to diagnosis and often have polypharmacy
