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On higher order time integration for thermal coupling

We consider the coupling of the compressible Navier-Stokes equations with the heat equation as a model for cooling processes in steel forming. The semidiscrete coupled system is solved using stiffly stable SDIRK methods of higher order, where on each stage, a fluid-structure interaction problem is solved. textcopyright 2009 American Institute of Physics.

FPGA based hybrid computing platform for ESS linac simulator

This paper presents a scalable and high-Throughput hybrid computing platform for the real-Time multi-particle based Linac (Linear accelerator) simulation model to be used at the European Spallation Source (ESS). The multi-particle simulation model with non-linear modeling is needed to provide a realistic behavior of the particle beam for reducing the losses at the superconducting structures. The c

Implementation of an area efficient crypto processor for a NB-IoT SoC platform

This paper presents a cryptographic processor compliant with the security algorithms specified by the 3rd Generation Partnership Project (3GPP) specifications for Long Term Evolution (LTE). The proposed processor has been adapted to the needs of the low end portfolio technologies that compose the Internet of Things (IoT) market, which addresses low-Area, low-cost and low-data rate applications. Th

MafA expression preserves immune homeostasis in human and mouse islets

Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, and have also been implicated in the regulation of immunomodulatory cytokines like interferon-β (IFNβ1). In this study, we assessed MAFA and MAFB co-expression with pro-inflammatory cytokine signaling genes in RNA-seq d

Measurement of the Zγ→νν¯¯¯γ production cross section in pp collisions at s√=13 TeV with the ATLAS detector and limits on anomalous triple gauge-boson couplings

The production of Z bosons in association with a high-energy photon (Zγ production) is studied in the neutrino decay channel of the Z boson using pp collisions at s√=13 TeV. The analysis uses a data sample with an integrated luminosity of 36.1fb−1 collected by the ATLAS detector at the LHC in 2015 and 2016. Candidate Zγ events with invisible decays of the Z boson are selected by requiring signific

An assembly factor promotes assembly of flavinated SDH1 into the succinate dehydrogenase complex

Succinate dehydrogenase (Complex II; SDH) plays an important role in mitochondrial respiratory metabolism. The SDH complex consists of four core subunits and multiple cofactors, which must be assembled correctly to ensure enzyme function. To date, only an assembly factor (SDHAF2) required for FAD insertion into subunit SDH1 has been identified in plants. Here, we report the identification of Arabi

Risk Stratification of Type 2 Long-QT Syndrome Mutation Carriers with Normal QTc Interval : The Value of Sex, T-Wave Morphology, and Mutation Type

Background: Long-QT (LQT) syndrome mutation carriers have higher risk of cardiac events than unaffected family members even in the absence of QTc prolongation. Changes in T-wave morphology may reflect penetrance of LQT syndrome mutations. We aimed to assess whether T-wave morphology may improve risk stratification of LQT2 mutation carriers with normal QTc interval. Methods: LQT2 mutation carriers

Worldwide trends in blood pressure from 1975 to 2015 : a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this an

Multimodal magnetic resonance imaging to identify stroke onset within 6 h in patients with large vessel occlusions

Introduction: Mechanical thrombectomy within 6 h after stroke onset improves the outcome in patients with large vessel occlusions. The aim of our study was to establish a model based on diffusion weighted and perfusion weighted imaging to provide an accurate prediction for the 6 h time-window in patients with unknown time of stroke onset. Patients and methods: A predictive model was designed based

Genomförbarhetsstudie och modellering av vattenflöden och nivåer i Malmö Botaniska Trädgård

Föreliggande rapport sammanfattar arbetet med att uppskatta vattenbalanser genom hydrologisk simulering för Malmö Botaniska Trädgård i Lindängelund, Malmö. Bedömning av maximalbehovet av bevattning inom biotopytorna visar på relativt små vattenflöden (totalt ca 6.2 l/s). Vid en antagen medelvattenhastighet om 10 cm/s (motsvarar ett lugnt flytande naturvattendrag) erhålls ett flöde på ca 80 l/s. Va

Measles and rubella seroimmunity in newly arrived adult immigrants in Sweden

Background: International migrants could be considered as a risk group for being susceptible to vaccine preventable diseases such as measles and rubella. However, data on immunity in different migrant groups are scarce. Apart from asylum seekers and refugees, other immigrant groups might also be at risk. We have examined measles and rubella specific IgG antibodies among newly arrived adult immigra

Simulering av vattenflöden och nivåer i Malmö Botaniska Trädgård

Föreliggande rapport sammanfattar arbetet med att uppskatta vattenbalanser genom hydrologisk simulering för Malmö Botaniska Trädgård i Lindängelund, Malmö. Bedömning av maximalbehovet av bevattning inom biotopytorna visar på relativt små vattenflöden (totalt ca 6.2 l/s). Vid en antagen medelvattenhastighet om 10 cm/s (motsvarar ett lugnt flytande naturvattendrag) erhålls ett flöde på ca 80 l/s. Va

The objective CORE score allows early rule out in acute chest pain patients

Objectives. Chest pain is a common complaint in the emergency department (ED), and it is a challenge to identify low-risk chest pain patients eligible for early discharge. We aimed to develop a simple objective decision rule to exclude 30-day major adverse cardiac events (MACE) in ED chest pain patients. Design. We analyzed prospectively included patients presenting with chest pain. Low risk patie

Roles of PDZ-dependent Interactions and N-glycosylation in G Protein-coupled Estrogen Receptor 1 (GPER1)/GPR30-mediated Stimulation of ERK1/2 Activity

G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor (GPCR) that is attracting considerable attention in breast cancer and cardiometabolic regulation. Following reports that GPR30 is required for some rapid estrogen responses, e.g. increased cAMP production and ERK1/2 activity, in estrogen receptor (ER)-negative cells, GPR30 was renamed G protein-coupled estrogen receptor 1 (GPER1

G protein-coupled Receptor 30 (GPR30) PDZ-dependently and Constitutively Increases ERK1/2 Signaling Through Calcineurin and Kinase Suppressor of Ras 2 (KSR2)

The objective of the present study was to map the mechanism whereby G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor (GPER), stimulates extracellular signal-regulated kinase (ERK)1/2 signaling. GPR30 plays important roles in cancer and cardiometabolic regulation. We showed recently that GPR30 forms a plasma membrane complex through its C-terminal type I PSD-95

Preoperative CT of cardiac veins for planning left ventricular lead placement in cardiac resynchronization therapy

Background: Successful cardiac resynchronization therapy (CRT) requires appropriate left ventricular (LV) lead placement on a suitable segment of the free LV wall. Current guidelines suggest targeted lead placement, but the individual anatomy of the cardiac veins is often a limiting factor. Purpose: To map cardiac veins with multidetector computed tomography (MDCT) and plot the veins in cardiac se

Arsenite methyltransferase (AS3MT) polymorphisms and arsenic methylation in children in rural Bangladesh

BACKGROUND: Arsenic methylation efficiency, a susceptibility factor for arsenic toxicity, is in adults partly explained by variation in arsenite methyltransferase (AS3MT) gene. Little is known about the role of AS3MT for children's arsenic methylation.OBJECTIVES: Evaluating associations between AS3MT polymorphisms and children's arsenic methylation efficiency.METHODS: Bangladeshi children's arseni

Maternal selenium status and neuropsychological development in Spanish preschool children

BACKGROUND: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex an

Prenatal arsenic exposure is associated with increased plasma IGFBP3 concentrations in 9-year-old children partly via changes in DNA methylation

Exposure to inorganic arsenic (As), a carcinogen and epigenetic toxicant, has been associated with lower circulating levels of insulin-like growth factor 1 (IGF1) and impaired growth in children of pre-school age. The aim of this study was to assess the potential impact of exposure to As on IGF1 and insulin-like growth factor-binding protein 3 (IGFBP3) as well as DNA methylation changes in 9-year-