Multifocal plane microscopy allows for capturing images at different focal planes simultaneously. Using a proprietary prism which splits the emitted light into paths of different lengths, images at 8 different focal depths were obtained, covering a volume of 50x50x4 μm3. The position of single emitters was retrieved using a phasor-based approach across the different imaging planes, with better tha

The research area of climate field reconstructions has developed strongly during the past 20 years, motivated by the need to understand the complex dynamics of the earth system in a changing climate. Climate field reconstructions aim to build a consistent gridded climate reconstruction of different variables, often from a range of climate proxies, using either statistical tools or a climate model

This paper revisites the direct synthesis tuning method of continuous-time low-order controllers, and specially PID controllers, for control of time-delayed single-input single-output processes. A setpoint prefilter is included to improve the servo response and integrating load disturbances are accounted for. Robustness is addressed by the feedback controller to obtain the desired maximum sensitiv

Although the use of location-based data (location coupled with semantic information) within Geographical Information Systems (GIS) and from Earth Observation (e.g. satellite) sources has been long established for decision makers, this has only recently been reflected in the construction sector with a more recent move from Computer Aided Design (CAD) to Building Information Modelling. BIM has opene

The success of an evidence-based intervention depends on precise and accurate evaluation of available data and information. Here, the use of robust methods for evidence evaluation is important. Epidemiology, in its conventional form, relies on statistics and mathematics to draw inferences on disease dynamics in affected populations. Interestingly, most of the data used tend to have spatial aspects

BACKGROUND The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking. METHODS We used nationwide Swedish demographic and health registers to follow an open population of 1

The digitalization of the process for building permit (involving the use of 3D information systems) is seen as a priority in a wide part of the world. Since it is a very multidisciplinary use case, involving a variety of stakeholders tackling complex issues and topics, some of them joined their efforts and skills in the European Network for Digital Building Permit. The initial activity of the netw

Background The scaphoid is the most commonly fractured carpal bone in adults as well as in children. Previous studies have reported a wide range of fracture incidences. Scaphoid fractures and non-unions in children have been sparsely investigated. Aim To perform a systematic review of the current literature on epidemiology of scaphoid fractures and non-unions in adults and children. Methods An ele

We demonstrate that the method of interleaved resampling in the context of parton showers can tremendously improve the statistical convergence of weighted parton shower evolution algorithms. We illustrate this by several examples showing significant statistical improvement.

Background: User involvement is a requirement of most research funders. There is a growing body of literature exploring the benefits and challenges of user involvement in research, but such studies are scarce in the field of aging and health. Moreover, the majority of such research is qualitative, which limits the generalizability of results. The UserAge panel study will be instrumental in expandi

Ett systematiskt arbetsmiljöarbete med fokus på alla åldrar bör fokusera på människors förmåga och vilja att arbeta, exempelvis genom en modell med fyra olika sfärer som relaterar till olika sätt att definiera ålder.Den första sfären handlar om hälsoeffekter och relaterar till den biologiska åldern. De andra sfärerna rör privatekonomi, stöd och gemenskap samt arbetstagarnas möjligheter att utföra

Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate. There are currently 15 known human isoforms of carbonic anhydrase with different functions and distribution in the body. This links to the relevance of hCA variants to several diseases such as glaucoma, epilepsy, mountain sickness, ulcers, osteo

The hallmark of sex chromosome evolution is the progressive suppression of recombination which leads to subsequent degeneration of the non-recombining chromosome. In birds, species belonging to the two major clades, Palaeognathae (including tinamous and flightless ratites) and Neognathae (all remaining birds), show distinctive patterns of sex chromosome degeneration. Birds are female heterogametic