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SIGNIFICANCE: The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and cardiac sarcoidosis (CS) can show significant overlap in their clinical presentation. Differentiation between both is crucial for optimal patient management. Aim of this study is to develop an ECG-based machine learning model to distinguish between ARCV and CS patients. The study population included 100 patients (50 with ARCV and 50 with C
Anette Svensson och Jenny Malmqvist, författarna till ”Berätta utanför ramarna: Känslor och transmedialt berättande som litteraturdidaktisk resurs”, gör en närläsning av specialnumret Bamse: Nina i knipa som är en del i Pressbyråns lässtimulerande samarbetsprojekt. Numret består bland annat av John Ajvide Lindqvists novell ”Nina i knipa” (2018), som är en omarbetning av serien med samma namn från
I maj 2021 infördes en ny straffbestämmelse som kriminaliserar uppmaning till självmord. Bestämmelsen är brett utformad, för fällande dom krävs varken att uppmaningen lett till faktiska konsekvenser eller en konkret risk för självmord, det räcker att uppmaningen typiskt sett kunnat medföra en sådan risk. Brottet har också en oaktsamhetsvariant, som möjliggör lagföring av den som uppmanat till själ
Advances the method of isnād-cum-matn analysis for unravelling complex aspects of early Islamic history • Establishes the earliest dating of the Qurʾanic codex based on the study of hadith • Contributes to the textual history of the Qur’an • Examines the claims regarding the integrity of the text of the Qur’an • Uses case studies of the verses on stoning and breastfeeding, making it relevant to co
Increased global vegetation gross primary productivity (GPP) over the past decades has led to an enhanced terrestrial carbon sink, an important factor in mitigating global warming. However, the global spatiotemporal evolution of GPP trends is still under debate, largely limiting our understanding of the sustainability in terrestrial carbon sink. Here in this study, based on a dozen of long-term gl
This entry examines pricing capabilities in B2B, challenging economic price theory assumptions by spotlighting the impact of firm-specific resources and capabilities on pricing strategies. Departing from traditional economic models that oversimplify market dynamics, this study draws on the resource-based view to emphasize how firms’ unique resources dictate their pricing success. It introduces the
The success in the adoption of autonomous vehicles is dependent on their ability to solve rarely occurring safety-critical corner cases. Vehicular communications (V2X) aim at improving safety and efficiency of autonomous driving by adding the capability of explicit inter-vehicular information exchange. We argue that V2X enables another important function, namely the support of ethical driving deci
High-throughput screening (HTS) three-dimensional (3D) tumor models are a promising approach for cancer drug discovery, as they more accurately replicate in vivo cell behavior than two-dimensional (2D) models. However, assessing and comparing current 3D models for drug efficacy remains essential, given the significant influence of cellular conditions on treatment response. To develop in vivo mimic
In this study, the thermal behavior in a Type IV hydrogen storage tank during fast charging was investigated by establishing a 2-dimensional axisymmetric model. The thermal properties of the real high-pressure hydrogen were considered and obtained from REFPROP software. The computing mesh with 15312 girds, the time step of 0.001 s, and the Realizable k-ε turbulence model were chosen to simulate hi
Recognising the increasing complexities posed by climate challenges to urban environments, it is crucial to develop holistic capabilities for urban areas to effectively respond to climate-related risks, forming the backbone of sustainable urban planning strategies and demanding a comprehensive understanding of urban climate justice. It requires a thorough examination of how climate change exacerba
This study investigates the interaction of KEIF, the intrinsically disordered N-terminal region of the magnesium transporter MgtA, with lipid bilayers mimicking cell membranes. Combining experimental techniques such as neutron reflectometry (NR), quartz-crystal microbalance with dissipation monitoring (QCM-D), synchrotron radiation circular dichroism (SRCD), and oriented circular dichroism (OCD),
Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue. Methods: MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason
The present study focuses on the computation of interfacial excess potential for the cohesive zones through which a brittle crack propagates in tungsten (W) twist grain boundaries (TGBs). Additionally, the influence of phosphorus (P) impurities is investigated. To this end, we have performed classical atomistic modeling of several ⟨110⟩ TGBs in their pristine and P-impurity segregated states. The
