Bayesian Optimization has emerged as a crucial technique for optimizing costly, black-box functions where each evaluation comes at a high cost, such as in scientific experiments, and machine learning hyperparameter optimization. By combining probabilistic modeling with sequential decision-making, Bayesian Optimization achieves efficient exploration, guiding the search toward optimal parameters wit

För att bromsa utsläppen av växthusgaser behöver vi utveckla nya metoder för att generera, lagra och omvandla förnybar energi. Vätgas kan lagras i bränsleceller som vid förbränning enbart genererar vatten som biprodukt. Svårigheten med vätgas är att den behöver lagras och transporteras på ett säkert sätt då den är explosiv och väldigt reaktiv i gasform. Ett förslag är att man använder sig av molekThe environmental impact of mankind significantly affects the climate, where 2/3 of the CO2 emissions are generated by transportation. The green transition of fuels needs to happen fast, and finding alternative options to generate, store and transform energy is important. Hydrogen powered fuel cells can combust hydrogen to generate electricity, with only water as a byproduct. At ambient temperatur

Misfolding, self-assembly, and subsequent deposition of amyloid β plaques and tau tangles are closely associated with Alzheimer’s disease (AD) and its neurodegenerative processes, driving healthy neurons into a diseased state. At present, AD is the most widespread form of dementia, causing profound personal and familial hardship as well as imposing a substantial societal economic burden.Currently,The purpose of the work that forms the basis of this thesis has been to investigate fundamental properties of amyloid β and tau self-assembly and their solubility. The results of this research are presented as five research articles. In Paper I, a solubility assay for determining the solubility of amyloid proteins is developed and its use demonstrated for the Aβ40 peptide. Paper II finds that tau

Vem styr det civila samhället i Sverige? Denna viktiga gemensamma del av samhället, skild från staten och marknaden, framställs ofta som en motvikt till den maktordning som gäller i politik och näringsliv. I rörelser som idrottsföreningar, intressegrupper och trossamfund kan strukturerna tyckas mer tillåtande och inkluderande. Men vad vet vi egentligen om det civila samhällets interna hierarkiska

Mounting climate-related floods, fires, droughts and storms across the globe raise crucial questions about the role of law in adjudicating rights and obligations. While climate litigation attracts scholarly attention, vulnerable populations often lack the means to use formal laws and courts. We draw on ethnographic interviews conducted in 2022 in the city of Cartagena, Colombia, to study how resid

Nature-based solutions, such as urban green spaces, are shown to contribute to carbon emissions reduction and carbon sequestration, and also to have valuable indirect effects and behavioural impacts. Implementing such solutions could achieve carbon neutrality within the decade in several major cities in Europe.

Adapting successes of policy transition from one city to another has been more difficult than single case of successful sustainability-driven projects and developments. A thorough understanding of local biophysical and socio-economic conditions is essential in formulating effective development plans and policies. Here, we propose the use of a social-ecological model as a comparative tool to help u

Climate change poses a threat to cities. Geospatial information and communication technology (Geo-ICT) assisted planning is increasingly being utilised to foster urban sustainability and adaptability to climate change. To fill the theoretical and practical gaps of urban adaptive planning and Geo-ICT implementation, this article presents an urban ecosystem vulnerability assessment approach using in

The polymer electrolyte fuel cells are electrochemical devices that can produce electricity, water, and heat through chemical reactions of hydrogen and oxygen. This manuscript focuses on one detailed state of degradation, called as Membrane Chemical Stability and Metrics. The Accelerated Stress Test under study was standardized by the Department of Energy. Recent advancements in the study of degra

When someone violates a social norm, others may think that some sanction would be appropriate. We examine how the experience of emotions like anger and disgust relate to the judged appropriateness of sanctions, in a pre-registered analysis of data from a large-scale study in 56 societies. Across the world, we find that individuals who experience anger and disgust over a norm violation are more lik

Research question: Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness? Design: The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-ye

In the context of accelerated urbanization, socioeconomic development, and population growth, as well as the rapid advancement of information and communication technology (ICT), urban land is rapidly expanding worldwide. Unplanned urban growth has led to the low utilization efficiency of land resources. Also, ecological and agricultural lands are continuously sacrificed for urban construction, whi

Group A Streptococcus (GAS)causes infections ranging from mild sore throats to severe invasive disease; however, no licensed vaccine is currently available. In this thesis, the author leverages streptolysin O (SLO), an important GAS protein and therapeutic/vaccine target, as a model system to develop a multimodal protein mass spectrometry(MS) strategy. Through an integrated approach of MS-based pr

This paper suggests an approach to solving the time-of-arrival self-calibration problem for imbalanced problems, where there is a low number of receivers but many senders. The idea is to solve several subproblems created by only using data relating to four receivers. The solutions are then clustered according to a proposed metric in order to remove failed reconstructions. They are then combined in

As global climate change intensifies, the question of what makes a place habitable or uninhabitable is critical, particularly in the context of a potential future climate outside the realm of lived experience, and the possible concurrent redistribution of populations partly associated with such climatic shifts. The concept of habitability holds the potential for advancing the understanding of the

In this paper we propose minimal solvers for relative pose estimation for two views of the projected silhouettes of two 3D cylinders. Using such line features instead of the standard point feature correspondences means more stable information (i.e. more stable to lighting condition, seasons, changes in environment etc.). Such features also lead to more compact and semantically interpretable repres