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Objective: More than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes. Methods: Patients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined
Purpose: To optimize a whole-brain magnetization transfer saturation (MTsat) protocolat 7T, focusing on maximizing obtainable MTsat under the constraints of specificabsorption rate (SAR) and transmit field inhomogeneity, while avoiding bias and keeping scan time short.Theory and Methods: MTsat is a semi-quantitative metric, obtained by spoiled gradient-echo MRI in the imaging steady-state. Optimiz
A Large Intelligent Surface (LIS) is a recently pro-posed concept that relies on the integration of a vast number of antenna-elements over an entire surface able to transmit and/or receive information, especially suitable for high speed indoor communications and massive internet of things (IoT) applications. In this paper, we study the impact of terminal mobility on the performance of a panel-base
Massive MIMO enables a very high spectral efficiency by spatial multiplexing and opens opportunities to reduce transmit power per antenna. On the other side, it also introduces new challenges in tackling the power amplifier nonlinearity due to the increased number of antennas. The behavior of Out-of-Band radiation from PAs in Massive MIMO is non-trivial depending upon the applied precoding scheme,
Internet of Things (IoT) applications are emerging in many different areas, including maritime environments. One of the applications in this area is the monitoring of buoys at sea. To realize wireless tracking of buoys, an accurate prediction of the path loss in an open-sea environment is essential. So far, channel measurements at sea have mainly been conducted with antennas placed a couple of met
The Covid-19 pandemic has spawned numerous dynamic modeling attempts aimed at estimation, prediction, and ultimately control. The predictive power of these attempts has varied, and there remains a lack of consensus regarding the mechanisms of virus spread and the effectiveness of various non-pharmaceutical interventions that have been enforced regionally as well as nationally. Setting out in data
To date, not that much. Improvements are possible, but some system-theoretically grounded re-design is necessary. We discuss the matter based on our experience, and as a consequence, we come to distilling some design clues and research directions.
Based on a discrete choice experiment with 336 consumers, this study investigated whether the consumer propensity to choose a simplified European Union (EU) vs. non-EU denomination of origin for beef, instead of a specific country-of-origin (COO) denomination, depends upon the amount and type of credence information provided to the individual. The likelihood of choosing the EU/non-EU denomination
A lion’s roar, a dog’s bark, an angry yell in a pub brawl: what do these voca-lizations have in common? They all sound harsh due to nonlinear vocal phenomena (NLP)—deviations from regular voice production, hypothesized to lower perceived voice pitch and thereby exaggerate the apparent bodysize of the vocalizer. To test this yet uncorroborated hypothesis, we synthesized human nonverbal vocalization
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cell
Information flows can affect people’s apprehension of the pandemic and related behaviors. The aim is to explore how people access and assess COVID-19 information and whether sociodemographic factors are associated with these processes. Quantitative data from 928 persons from 29 countries who participated in an international web-based survey was analyzed with descriptive and analytic statistics. TeInformation flows can affect people’s apprehension of the pandemic and related behaviors. The aim is to explore how people access and assess COVID-19 information and whether sociodemographic factors are associated with these processes. Quantitative data from 928 persons from 29 countries who participated in an international web-based survey was analyzed with descriptive and analytic statistics. Te
PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis
In aging societies worldwide, spouses take on great responsibility for care when their partner continues to live at home. Nursing home placement occurs when the partner becomes too frail due to multimorbidity, and this will cause a change in the spouse’s life. This study aimed to explore the spouse’s experience of their partner’s move to a nursing home. Two interviews were conducted at 9-month int
Little is known about provision of medical services to adolescents prior to participating in international top-level sports. This study aimed to investigate experiences of medical service provision among high-level adolescent athletics (track and field) athletes from three continents. A thematic narrative analysis was applied to data collected from 14 athletes by semi-structured interviews. Althou
Purpose: Recessive cytosolic aminoacyl-tRNA synthetase (ARS) deficiencies are severe multiorgan diseases, with limited treatment options. By loading transfer RNAs (tRNAs) with their cognate amino acids, ARS are essential for protein translation. However, it remains unknown why ARS deficiencies lead to specific symptoms, especially early life and during infections. We set out to increase pathophysi
