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Resistance to therapy remains a major cause of cancer treatment failures, resulting in many cancer-related deaths. Resistance can occur at any time during the treatment, even at the beginning. The current treatment plan is dependent mainly on cancer subtypes and the presence of genetic mutations. Evidently, the presence of a genetic mutation does not always predict the therapeutic response and can
Karst is a widespread ecosystem with properties that affect the microbial activity and storage and cycling of soil organic carbon. The mechanisms underlying microbial resource availability in karst, which limit the microbial growth and activity in soil aggregates, remain largely unknown. We assessed the microbial resource limitations using exoenzymatic stoichiometry and key extracellular enzyme ac
Background: Prospectively and systematically collected real-world data on vedolizumab are scarce. We aimed to assess the long-term clinical effectiveness of vedolizumab in inflammatory bowel disease (IBD). Methods: This study was a prospective, observational, multicentre study. Overall, 286 patients with active IBD were included (Crohn’s disease, n = 169; ulcerative colitis, n = 117). The primary
INTRODUCTION Continuity models of midwifery care are significant factors in facilitating a positive childbirth experience for birthing women. A knowledge gap exists regarding partners' experiences of continuity of midwifery care during pregnancy, birth, and after birth, although it is essential to understand the experiences of both parents in relation to continuity of care. Thus, the aim of this s
INTRODUCTION Continuity models are rare in Sweden. The aim was to compare the intrapartum care experiences between women who had or not a known midwife attending their birth. METHODS A cohort study was conducted in a rural area with long distance to a labor ward in Sweden. From August 2017 to June 2019, a continuity model with a known midwife was offered between 7 a.m. and 11 p.m. daily. Questions
INTRODUCTION The closure of a local labor ward enhanced the possibility to initiate a continuity of midwifery care model project. Continuity models of midwifery care are a cornerstone in midwifery and women-centered care, mainly accessible in metropolitan areas. Australian studies have found continuity of midwifery care to work well in rural areas. The aim of this study is to describe midwives’ ex
Exposure to phthalates is widespread and especially early life stages represent a critical window of exposure. In the present study, we investigated the effect of prenatal exposure to phthalates on birth outcomes and weight development in early life. In 130 mother–child pairs, we estimated the association of concentrations of 13 phthalates in spot-urine samples collected during pregnancy and birth
The COVID-19 pandemic has affected care workers all over the globe, as older and more vulnerable people face a high risk of developing severe symptoms and dying from the virus infection. The aim of this study was to compare staff experiences of stress and anxiety as well as internal and external organizational support in Sweden, Italy, Germany, and the United Kingdom (UK) in order to determine how
One of the most important decisions coalition partners make when forming a government is the division of ministries. Ministerial portfolios provide the party in charge with considerable informational and agenda-setting advantages, which parties can use to shape policies according to their preferences. Oversight mechanisms in parliaments play a central role in mitigating ministerial policy discreti
Theoretical and experimental literature have provided mixed insights on the ability of financial markets to perfectly aggregate private information into asset prices. We conduct an experiment designed to benchmark information aggregation in markets. In our lab experiment, we randomly assign subjects to different institutional environments, either a market or a Becker–DeGroot–Marschak mechanism. We
Introduction/objective: Diagnostic delays in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are related to increased morbidity and mortality. The risk of a delayed, or even a missed, diagnosis is high as the conditions are rare. The aim was to describe patients’ and spouses’ experiences of the journey from the first symptom to an established diagnos
Background: Preeclampsia (PE) is a complex pregnancy syndrome characterised by maternal hypertension and organ damage after 20 weeks of gestation and is associated with an increased risk of cardiovascular disease later in life. Extracellular haemoglobin (Hb) and its metabolites heme and iron are highly toxic molecules and several defence mechanisms have evolved to protect the tissue. Objectives: W
Katarzyna Herds bidrag synar hur fotbollssupportrar reagerat på avsaknaden av fysiska fotbollsmatcher under det gångna året. Hennesartikel behandlar hur man upprätthåller engagemang för sitt lag genom crowdfunding-kampanjer och virtuella bortamatchbussar, och ställer sig frågan hur man konsumerar fotboll när man inte kan gå på fotboll.This article is based on the lack of football activities during the global pandemic of 2020 (and unfortunately still in the beginning of 2021), focusing on a Swedish club from Stockholm called AIK (Allmänna Idrotsklubben). This lack of activities presentedin the article happened between April 2020 and March 2021.
This study contributes to debates on the efficacy of institutions in settler colonies by comparing the Cape Colony’s fiscal path to the experiences of Australia, New Zealand, and Canada. I find that the Cape’s fiscal trajectory was divergent. Agricultural and mining taxes were important surrogates of income taxes in other colonies, but the Cape’s narrow interests pushed for insulation from direct
OBJECTIVE: The present population-based study aimed to examine the association of chronic stress and sleeping difficulties with self-reported irritable bowel syndrome (IBS), gastrointestinal (GI) symptoms past 2 weeks, and psychological well-being.RESULTS: The Malmö Offspring Study included subjects from the general population to complete a questionnaire regarding sociodemographic factors, lifesty
Today's rapidly evolving and changing market dictates constant changes in design requirements during the development process of a product. If development teams are unable or unwilling to adapt to these changes, this will ultimately lead to an uncompetitive product. How the change in requirements will affect the development process depends on the complexity of the product and the development phase
Additive manufacturing (AM), which was first applied for rapid prototyping, is now becoming a real option for small-batch production of final products. Further expansion of AM is closely correlated to production costs. AM can only become competitive to traditional manufacturing methods if a product is designed for AM already from the beginning as it is an expensive technology that should only be a
Background: Previous research shows that many cancer-bereaved youths report unresolved grief several years after the death of a parent. Grief work hypothesis suggests that, in order to heal, the bereaved needs to process the pain of grief in some way. This study explored acute grief experiences and reactions in the first 6 months post-loss among cancer-bereaved teenagers. We further explored long-
