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A CFD-based approach to study cavitation in high-pressure homogenizer valves. Part 2. Cavitation intensity

Hydrodynamic cavitation take place in high-pressure homogenizer (HPH) valves. Cavitation wear, free radical formation and ultrasonic emissions are linked to the cavitation intensity. Cavitation intensity is also a key factor to understand any effect cavitation might have on particle breakup. Based on an approach used in previous studies on other devices, this contribution applies and tests a model

Drivers of Industry 5.0 technologies in dairy industry : an exploratory study

This paper aims to identify and analyse the key drivers affecting the adoption of Industry 5.0 (I5.0) technologies in the dairy industry. The data collected from various dairy stakeholders was analysed using Exploratory Factor Analysis (EFA) to uncover the underlying factors, and Multiple Linear Regression (MLR) was employed to evaluate the impact of the factors on the adoption level of I5.0 techn

Disease stage-specific atrophy markers in Alzheimer's disease

INTRODUCTION: Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrophy markers for different intended uses.METHODS: We included 363 older adults; cognitively unimpaired individuals who were negative or positive for amyloid beta

Tau, atrophy, and domain-specific cognitive impairment in typical Alzheimer's disease

INTRODUCTION: A granular understanding of the mechanisms linking tau pathology to cognitive decline in Alzheimer's disease is crucial. We investigate mediating effects of medial temporal lobe (MTL) and neocortical neurodegeneration on tau-induced domain-specific cognitive impairment in amyloid-beta (Aβ) positive cognitively normal and impaired adults.METHODS: We assessed magnetic resonance imaging

Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases

The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer's disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imaging (MRI) scans, we aimed to (