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Recent advances in time-resolved luminescence spectroscopy at MAX IV and PETRA III storage rings

Short-wavelength synchrotron radiation excitation has been an indispensable tool in the studies of the properties of wide gap materials using time-resolved low-temperature luminescence spectroscopy. In recent years, several setups for such investigations have been launched at MAX IV Laboratory and Photon Science at DESY. Two permanently stationed time-resolved luminescence setups at FinEstBeAMS an

Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations

Objective: The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together with HLA-DRB1 alleles and immunological and clinical data. Methods: An unsupervised cluster analysis was performed based on detection of 13 SLE-associated autoanti

Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19

Background: Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease

For optimal design of anti-amyloid-β (Aβ) and anti-tau clinical trials, we need to better understand the pathophysiological cascade of Aβ- and tau-related processes. Therefore, we set out to investigate how Aβ and soluble phosphorylated tau (p-tau) relate to the accumulation of tau aggregates assessed with PET and subsequent cognitive decline across the Alzheimer's disease (AD) continuum. Using hu

Multiple Offsets Multilateration: : A New Paradigm for Sensor Network Calibration with Unsynchronized Reference Nodes

Positioning using wave signal measurements is used in several applications, such as GPS systems, structure from sound and Wifi based positioning. Mathematically, such problems require the computation of the positions of receivers and/or transmitters as well as time offsets if the devices are unsynchronized. In this paper, we expand the previous state-of-the-art on positioning formulations by intro

Coping in Mid- to Late Life and Risk of Mild Cognitive Impairment Subtypes and Dementia : A JPHC Saku Mental Health Study

BACKGROUND: The relationship between coping in mid- to late life and cognitive functions remains unclear. OBJECTIVE: To investigate the relationship between habitual coping behaviors of a large Japanese population in their mid- to late-lives and their risk of cognitive decline 15 years later. METHODS: Overall 1,299 participants were assessed for coping behaviors (in 2000) and cognition (2014-2015)

The mid-Ordovician meteorite flux to Earth shortly before breakup of the L-chondrite parent body

The breakup of the L-chondrite parent body (LCPB) in the asteroid belt at 466 Ma ago is the largest asteroid breakup documented in Earth's geological record for the past ca. three billion years. Recovery of abundant macroscopic fossil L chondrites in mid-Ordovician marine sediments as well as reconstructions of the flux of micrometeoritic chrome spinel through the ages have given much new informat

Poor psychological health and 8-year mortality : a population-based prospective cohort study stratified by gender in Scania, Sweden

Objectives We investigated gender differences in the association between mortality and general psychological distress (measured by 12-item General Health Questionnaire, GHQ-12), as an increased mortality risk has been shown in community studies, but gender differences are largely unknown. Setting We used data from a cross-sectional population-based public health survey conducted in 2008 in the Swe

Evaluation of the VISAGE basic tool for appearance and ancestry inference using ForenSeq® chemistry on the MiSeq FGx® system

The possibility of providing investigative leads when conventional DNA identification methods fail to solve a case can be of extreme relevance to law enforcement. Therefore, the forensic genetics community has focused research towards the broadened use of DNA, particularly for prediction of appearance traits, bio-geographical ancestry and age. The VISible Attributes through GEnomics (VISAGE) Conso

An experimental investigation on the thermal augmentation of internal endwall in a two-pass duct using an array of delta-winglet vortex generator pair

The present study experimentally demonstrates a novel design for an internal endwall in a two-pass duct heat exchanger. An array of delta-winglet vortex generator pairs with different aspect ratio, angle of attack, configuration are mounted on the internal endwall in a U duct. Liquid crystal thermalgraphy and static pressure measurements are utilized in this study to evaluate the heat transfer, th

Laser Doppler flowmetry evaluation of skin microvascular endothelial function in patients with metabolic syndrome

Background: Metabolic syndrome (MetS) is associated with high cardiovascular morbidity and mortality, and endothelial dysfunction is an early pathogenetic event in the MetS. Lifestyle changes and pharmacological intervention might partly restore endothelial function in MetS. Whereas an optimal non-invasive test for endothelial dysfunction is still being sought, the aim of this study was to assess

Simplex Lattice Design and X-ray Diffraction for Analysis of Soil Structure : A Case of Cement-Stabilised Compacted Tills Reinforced with Steel Slag and Slaked Lime

Evaluating the structure of soil prior to building construction is valuable in a large variety of geotechnical and civil engineering applications. To built an effective framework for assessing the strength of the stabilised soil, the presented workflow includes a complex approach of simplex lattice design and X-ray diffraction for the analysis of soil structure. Different from the traditional in s

Further Evidence of Allergic Contact Dermatitis Caused by 2,2′-Methylenebis(6- tert -Butyl-4-Methylphenol) Monoacrylate, a New Sensitizer in the Dexcom G6 Glucose Sensor

Background Since the spring of 2020, we have seen several patients experiencing severe allergic contact dermatitis (ACD) from the Dexcom G6 glucose sensor after the composition of the sensor's adhesive patch had been changed. We have previously reported the finding of a new sensitizer, 2,2′-methylenebis(6-tert-butyl-4-methylphenol) monoacrylate, in the Dexcom G6 adhesive patch. Three patients with

Trophic strategies of intertidal foraminifera explored with single-cell microbiome metabarcoding and morphological methods : What is on the menu?

In mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and t