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It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27 312 individuals with a comprehensive set of low frequency coding varia
In Europe postgraduate training to become a geriatrician is regulated by national governments. To gain some insight how these regulations work in practice students of the Xth EAMA Postgraduate Course in Geriatrics prepared a presentation on how to become a geriatrician in their country. This article summarizes and compares the given information of 16 European countries illustrating an extensive di
Background: Social support has a strong impact on individuals, not least on older individuals with health problems. A lack of support network and poor family or social relations may be crucial in later life, and represent risk factors for elder abuse. This study focused on the associations between social support, demographics/socio-economics, health variables and elder mistreatment. Methods: The c
Oligodendrocytes are part of the glial cells located in the central nervous system, capable of providing trophic support to neurons and ensheathing their axons. These cells can become dysfunctional under pathologic condition. Rodent and human pluripotent stem cells are inexhaustible sources for producing oligodendrocytes that can be used for disease modeling and cell replacement therapy studies. T
We analyzed seasonal influenza vaccination coverage among the Italian healthcare workers (HCW) in order to identify socio-demographic and clinical determinants of vaccination. We used data from the survey "Health and health care use in Italy," which comprised interviews of 5,336 HCWs For each respondent, information on socioeconomic, health conditions, self-perceived health and smoking status were
The invention relates to hyperpolarised 13C-α-ketoisocaproate, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-α-ketoisocaproate and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-α-ketoisocaproate.The invention relates to hyperpolarised 13C-α-ketoisocaproate, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-α-ketoisocaproate and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-α-ketoisocaproate.
Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verific
The El Niño–Southern Oscillation (ENSO) is dominant mode of interannual climate variability, but its response to external climate forcings remains uncertain. Past studies have limitations including the use of short datasets and the uncertainty contained in reconstructions or simulations of past ENSO variations. To improve our understanding on ENSO variations, it is important to examine its respons
Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominated retinopathy, we identified five homozygous variants [p.(Asp594fs), p.(Gln117*), p.(Met712fs), p.(Ile756Phe), and p.(Glu543Lys)] in the polygl
The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-lactate and to an imaging medium containing hyperpolarised 13C1-lactate for use in said method.The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-lactate and to an imaging medium containing hyperpolarised 13C1-lactate for use in said method.
The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-acetate and to an imaging medium comprising hyperpolariscd 13C-acetate.
The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.
Polymer nanogels are embedded within layers consisting of a nonlamellar liquid crystalline lipid phase to act as thermoresponsive controllers of layer compactness and hydration. As the nanogels change from the swollen to the collapsed state via a temperature trigger, they enable on-demand release of water from the mixed polymer-lipid layer while the lipid matrix remains intact. Combining stimuli-r
Background Diet and smoking are the main sources of cadmium exposure in the general population. Cadmium increases the risk of cardiovascular diseases, and experimental studies show that it induces inflammation. Blood cadmium levels are associated with macrophages in human atherosclerotic plaques. Soluble urokinase-type plasminogen activator receptor (suPAR) is an emerging biomarker for cardiovascu
The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.
The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
Host–pathogen protein–protein interaction networks are highly complex and dynamic. In this experimental protocol we describe a method to isolate host proteins attached to the bacterial surface followed by quantitative mass spectrometry based proteomics analysis. This technique provides an overview of the host–pathogen interaction network, which can be used to guide directed perturbations of the sy
The invention relates to a method of producing a composition comprising hyperpolarised 13C-pyruvate, the composition and its use as an imaging agent for MR imaging.
The streaming instability is a mechanism to concentrate solid particles into overdense filaments that undergo gravitational collapse and form planetesimals. However, it remains unclear how the initial mass function of these planetesimals depends on the box dimensions of numerical simulations. To resolve this, we perform simulations of planetesimal formation with the largest box dimensions to date,
