Genome scans in recently separated species can inform on molecular mechanisms and evolutionary processes driving divergence. Large-scale polymorphism data from multiple species pairs are also key to investigate the repeatability of divergence-whether radiations tend to show parallel responses to similar selection pressures and/or underlying molecular forces. Here, we used whole-genome resequencing

BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of

HAMSTERS and mice inoculated at birth with tumour viruses have been used in studies of the prophylactic effects of various treatments during the latent period. The incidence of primary tumours in hamsters infected at birth with SV40 is reduced if the virus is inoculated during the latent period1-3. Similar administration of adenovirus type 12 also inhibited the induction of tumours by SV404; this

BACKGROUND: Malignant mesothelioma (MM) is a therapy-resistant tumor, often causing an effusion. Drugs targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have shown promising results, but assessment of PD-L1 expression to select patients for therapy has mainly been performed on histologic tissue samples. In a previous study, we showed that MM effusions are

Detta dokument är framtaget som en intern rapport inom MerSam – Meritvärde av samverkansskicklighet, vars projekttid löpt under 2017 – 2020. MerSam är ett av Vinnovas 17 finansierade K3-projekt. Rapporten utgör en sammanställning av insamlad information från dokument, dialoger, workshoppar, intervjuer och enkäter. Rapporten visar på användning av begrepp och tolkning av begrepp. Syftet är att besk

Application of concurrent engineering (CE) to product development process (PDP) has to consider the type of production (individual, serial, mass), product complexity and level of design: original, innovative, variation and adaptive. Systematic analyses of product development processes, workflows, data and project management, in various companies, has shown that specific criteria have to be fulfill

Worldwide significant efforts are ongoing to develop devices that store solar energy as fuels. In one such approach, solar energy is absorbed by semiconductors and utilized directly by catalysts at their surfaces to split water into H2 and O2. To protect the semiconductors in these photo-electrochemical cells (PEC) from corrosion, frequently thin TiO2 interlayers are applied. Employing a well-perf

The aim of the present investigation was to test the Lysholm knee scoring scale from 1985 for sensitivity and reliability. Thirty-one patients with one of four different diagnoses: anterior cruciate ligament rupture (ACL), meniscus tear (MT), patello-femoral pain syndrome (PFPS) and lateral ankle sprain (LAS) participated in the study. None of the patients were in the acute phase of injury, and no

Tools and methods are an important part of product development process. Advantages of different methods are growing with product novelty and complexity. Moderation of product development team meeting is a challenge at face to face meetings. Moderation has to be conducted with additional care at spatially distributed or virtual teams. The workshops or meetings related to different tools and methods

Background Increased body temperature in the Emergency Department (BT-ED) and the ICU (BT-ICU) is associated with lower mortality in patients with sepsis. Here, we compared how well BTED and BT-ICU predict mortality; investigated mortality in various combinations of BT-ED and BT-ICU, and; compared degree of fever in the ED and ICU and associated quality of care. Methods 2385 adults who were admitt

This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18

The transition to a circular economy is a complex process requiring wide multi-level and multi-stakeholder engagement and can be facilitated by appropriate policy interventions. Taking stock of the importance of a well-balanced policy mix that includes a variety of complementing policy instruments, the circular economy action plan of the European Union (COM(2020) 98 final) includes a section about

We present a program allowing for the construction of a heavy ion Monte Carlo event using a general purpose proton–proton event generator of the users’ choice to deliver sub–collisions. In this heavy ion event, one or more jets can be added, again using a jet calculation of the users’ choice, allowing for more realistic simulation studies of jets in a heavy ion background.

This paper describes an original numerical prediction technique developed for the analysis of coupled vibro-acoustic problems in fluid waveguides. Specifically it is a wave-based method that adopts a spectral element approach. Unlike the conventional element-based methods, this technique uses wave functions that satisfy the governing equations to describe the dynamic variables exactly. One advanta