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OBJECTIVE: To determine the ability of montelukast, a leukotriene receptor antagonist, to allow tapering of inhaled corticosteroids in clinically stable asthmatic patients. DESIGN: Double blind, randomised, placebo controlled, parallel group study. After a single blind placebo run in period, during which (at most) two inhaled corticosteroids dose decreases occurred, qualifying, clinically stable p

During the last few years much interest has been focused on the photoprotective role of zeaxanthin. In excessive light zeaxanthin is rapidly formed in the xanthophyll cycle from violaxanthin, via the intermediate antheraxanthin, a reaction reversed in the dark. The role of zeaxanthin and the xanthophyll cycle in photoprotection, is based on fluorescence quenching measurements, and in many studies

Differential photoproduction cross sections are measured for events containing D-*+/- mesons. The data were taken with the H1 detector at the ep collider HERA and correspond to an integrated luminosity of 51.1 pb(-1). The kinematic region covers small photon virtualities Q(2) < 0.01 GeV2 and photon-proton centre-of-mass energies of 171 < W gamma(Cep) < 256 GeV. The details of the heavy quark produ

Conclusion. Lipopolysaccharide (LPS) challenge of the human nose has the capacity to reduce the amount of natural anti-inflammatory proteins, such as uteroglobin. Objectives. Nasal challenge with LPS, an activator of innate immunity, has been shown to increase the amount of pro-inflammatory mediators in nasal lavage fluid. Uteroglobin is a newly described anti-inflammatory mediator that is secrete

Elongation factor P is a universally conserved protein stimulating peptidyltransferase activity during protein synthesis. The factor is sensitive to classical inhibitors of the ribosomal peptidyltransferase activity and is possibly involved in alignment of the substrate tRNAs in the catalytic centre of 70S ribosomes. Elongation factor P from the thermophilic Aquifex aeolicus was overexpressed as a

Microalgae enhance the removal of nutrients, organic contaminants, heavy metals, and pathogens from domestic wastewater and furnish an interesting raw material for the production of high-value chemicals (algae metabolites) or biogas. Photosynthetic oxygen production also reduces the need for external aeration, which is especially advantageous for the treatment of hazardous pollutants that must be

1. The input characteristics and distribution of climbing fibre field potentials evoked by electrical stimulation of various parts of the skin were investigated in the cerebellum of barbiturate anaesthetized rats. 2. Climbing fibre responses were recorded in sagittally oriented microelectrode tracks across the mediolateral width of the anterior lobe. Climbing fibres with similar response latencies

Injury patterns and epidemiologic data from 211 moped accident victims and 214 motorcycle accident casualties admitted to hospital over a 5-year period (1977-1981) have been analyzed and compared. The number of those injured in motorcycle accidents tripled; the number of moped accident victims slightly decreased in the period studied. Differences in injury pattern, sex ratio, cause of accident, an

The paper examines the nonlinear behaviour of one- and two-degree-of-freedom discrete mechanical models subjected to partial follower load under conditions at which divergence instability occurs. Section (1.6) of the paper deals with the dynamic instability of an elastoplastic damped strut compressed by partial follower force at the free end. Space-time curves for the system are presented and disc

One-dimensional propagation of transient EM-waves in periodic media is studied. The media are periodic in the direction of propagation and can be of finite or infinite length. Wave propagators, that map a transient field from one point in the medium to another, are introduced. A number of useful relations for the propagators are presented. Some of these relations are used in the determination of e

Objectives. The aim of the study was to assess long-term state and trait anxiety in cardiac surgical risk patients. Design. Thirty two patients with serum S100B > 0.3 mu g/l 48 hours after cardiac surgery with cardiopulmonary bypass were matched according to age, gender, type, date and length of surgery with 35 operated patients without elevated S100B. They completed Spielberger's Anxiety Inventor

The conjugated polymer poly(2-methoxy-5-(2'-ethylhexyloxy)-1,4-pheiiylene vinylene) (MEH-PPV) was studied by a single-molecule imaging technique. A comparison of statistical distributions of fluorescence intensity with molecular weight distributions revealed that the distribution of the photoluminescence quantum yield of the single polymer chains under study is significantly asymmetric, with a pol