Context: Prostate cancer (PCa) is a clinically heterogeneous disease with marked variability in patient outcomes. Molecular characterization has revealed striking mutational heterogeneity that may underlie the variable clinical course of the disease. Objective: In this review, we discuss the common genomic alterations that form the molecular basis of PCa, their functional significance, and the pot

The rise of MEMS and µTAS techniques has created a whole new family of microfluidic devices for a wide range of chemical and biomedical analyses to be performed on small Lab-on-a-chip platforms. The operations often include small samples of particle or cell suspensions on which separation, mixing, trapping or sorting is performed. External fields and forces are used for these operations, and this

Purpose: We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function. Materials and Methods: Cannabinoid receptor 1 and 2 expression was studied with Western blot and immunohistochemistry in rat, monkey and human detrusors. Co-staining was done for markers of sens

Recension av bok om mytbildningar om andra världskriget.

We present a microgeographic analysis of 34 allozyme loci and the control region of mitochondrial DNA (mtDNA) in the common vole Microtus arvalis (Pallas, 1779), performed to assess the effects of environmental heterogeneity on the distribution of genetic variation among populations in the Biebrza river valley, NE Poland The common vole occurs there in two types of habitat open grassland and pastu

Background: When scaling up lignocellulose-based ethanol production, the desire to increase the final ethanol titer after fermentation can introduce problems. A high concentration of water-insoluble solids (WIS) is needed in the enzymatic hydrolysis step, resulting in increased viscosity, which can cause mass and heat transfer problems because of poor mixing of the material. In the present study,

Waste electrical and electronic equipment (WEEE) has caused concern from many sectors of society due to its growing quantity and potential toxicity. The situation is particularly worrisome in some non-OECD countries, such as India and China, where acute health and environmental hazards have resulted from a combination of a lack of proper WEEE management systems and the domination of a large backya

Context-aware computing is a typical paradigm of ubiquitous computing and aims to provide context information anywhere and anytime. Context data management which handles gathering, processing, managing, evaluating and disseminating context information is the heart of context-aware system. Context provision and acquisition, thus, become crucial for context-aware computing. In order to decouple appl

Accessible summary This article describes the life circumstances of persons with a psychiatric disability living in a region in southern Sweden. The respondents themselves describe their life circumstances in terms of their living conditions, occupation and activities, health, and formal and informal support. The results show that 77.5% are unmarried, which differ considerably from corresponding f

Background: The effects of acetic acid, a common food preservative, on the bacteriophage-encoded enterotoxin A (SEA) expression and production in Staphylococcus aureus was investigated in pH-controlled batch cultures carried out at pH 7.0, 6.5, 6.0, 5.5, 5.0, and 4.5. Also, genomic analysis of S. aureus strains carrying sea was performed to map differences within the gene and in the temperate phag

In this study linear free energy relationships (LFER) are applied to the relaxation of core-excited states in aliphatic CH3X compounds. There are at least two valence orbitals involved in Auger decay following C-CH3 1s -> sigma*(C-X) excitation, which may as well be localized on the substituents in this series. Therefore, the observed property cannot be strictly attached to the so-called reaction

This paper presents a discussion on the application and accuracy of roughness height formulas from a practical point of view. Such formulas have been proposed to describe the equivalent roughness height for plane bed conditions on the basis of the Shields parameter. The application of these relationships requires an iterative solution technique. However, as this paper demonstrates, the roughness e

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prosp

Popular Abstract in Swedish Avhandlingen handlar om vetenskaplig osäkerhet i policyprocessen, det vill säga när vetenskaplig kunskap om en fråga saknas eller den existerande kunskapen är osäker. Studiens huvudsyfte är att förstå om och hur vetenskaplig osäkerhet påverkar policyprocessen. För att undersöka detta har utvecklingen av den svenska klimatpolitiken från 1975 fram till 2007 studerats. MatThe dissertation is about scientific uncertainty in the policy process, that is when scientific knowledge about an issue is lacking or the existing knowledge is uncertain. The aim of the study is to understand if and how scientific uncertainty affects the policy process. For that purpose, the development of climate change policy in Sweden is studied, from 1975 until 2007. The material studied cons

Background: Diabetes accelerates atherosclerosis through undefined molecular mechanisms. Hyperglycemia induces formation of advanced glycation end product (AGE)-modified low-density lipoprotein (LDL). Anti-AGE-LDL autoantibodies favor atherosclerosis (AS) progression in humans, while anti oxidized LDL immunization inhibits AS in hypercholesterolemic, non-diabetic mice. We here investigated if AGE-

Background The safety of long-acting beta(2) agonist (LABA) therapy in asthma remains controversial but no large scale analyses have been published of LABA safety in children. Methods The frequency of asthma-related deaths and hospitalisations following formoterol use in children (4-11 years) and adolescents (12-17 years), compared with non-LABA treatment, was assessed in all AstraZeneca-sponsored