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Kinetic isotope effects of 12CH3D+OH and 13CH3D+OH from 278 to 313K

Methane is the second most important long-lived greenhouse gas and plays a central role in the chemistry of the Earth's atmosphere. Nonetheless there are significant uncertainties in its source budget. Analysis of the isotopic composition of atmospheric methane, including the doubly substituted species 13CH3D, offers new insight into the methane budget as the sources and sinks have distinct isotop

The pancreatic β-cell : A bioenergetic perspective

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique to the central processes of glucose-stimulated insulin secretion, including glycolytic and mitochondrial metabolism, the cytosolic adenine nucleotide pool, and its interaction with plasma membrane ion channels. The control mechanisms responsible for the unique respon

Diffuse Reflectance Spectroscopy for Surface Measurement of Liver Pathology

BACKGROUND: Liver parenchymal injuries such as steatosis, steatohepatitis, fibrosis, and sinusoidal obstruction syndrome can lead to increased morbidity and liver failure after liver resection. Diffuse reflectance spectroscopy (DRS) is an optical measuring method that is fast, convenient, and established. DRS has previously been used on the liver with an invasive technique consisting of a needle t

Whole-remnant and maximum-voxel SPECT/CT dosimetry in 131I-NaI treatments of differentiated thyroid cancer

Purpose: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC). Methods: Eighteen DTC patients were administered 1.11 GBq of 131I-NaI after near-total thyroidectomy and rhTSH stimulation. Two patients had two remnants, so in total dosimetry was performed f

Endothelium-dependent and-independent relaxation induced by resveratrol in rat superior mesenteric arteries

Resveratrol (Res) is a specific agonist of sirtuin 1, and has many cardioprotective effects. Although Res is able to relax various vascular beds, its pharmacological properties in rat superior mesenteric arteries and the underlying mechanism are not well clarified. The aim of present study was to investigate the vasorelaxant effects of Res on rat superior mesenteric arteries and the mechanisms inv

MapReduce Job Optimization : A Mapping Study

MapReduce has become the standard model for supporting big data analytics. In particular, MapReduce job optimization has been widely considered to be crucial in the implementations of big data analytics. However, there is still a lack of guidelines especially for practitioners to understand how the MapReduce jobs can be optimized. This paper aims to systematic identify and taxonomically classify t

Housing accessibility and its associations with participation among older adults living with long-standing spinal cord injury

Objectives: To describe the housing situation and aspects of participation among older adults living with long-standing spinal cord injury (SCI) with attention to SCI severity, and to examine whether and how objective housing accessibility (based on objectively measurable criteria) is associated with aspects of participation. Design: Cross-sectional study utilizing the assessment tools Impact on P

Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular hemorrhage in preterm infants

Secondary objectives:Secondary objectives:P Primary objective: To assess whether head midline position compared with any other head position is more effective in prevention or extension of germinal matrix-intraventricular hemorrhage in infants born at ≤ 32 weeks' gestational age. Secondary objectives: To perform subgroup analyses regarding gestational age, birth weight, intubated versus not intuba

A 280 W LDMOS broadband Doherty PA with 52% of fractional bandwidth based on a multi-line impedance inverter for DVB-T applications

We introduce a new technique for the design of an output combiner for Doherty power amplifier (DPA) and its effective exploitation for the development of a wideband laterally diffused metal oxide semiconductor (LDMOS) DPA. The design is enabled by a two-line impedance inverter for the DPA back-off operation, which is capable of 52% of fractional bandwidth. The technique is validated by the develop

Swedish Sonographers' perceptions of ergonomic problems at work and their suggestions for improvement

Background: Sonographers' perceptions of ergonomic and work-related pain problems at work have so far mostly been researched in quantitative studies by questionnaires. There is a need of experience-based research to deepen the knowledge about how sonographers perceive ergonomic problems at work. Therefore, the aim of this qualitative study was to describe sonographers' perceptions of ergonomic pro

Supercontinuum generation in a multi-plate medium

We analyze femtosecond supercontinuum generation in a distribution of thin solid plates to show that the distributed scheme inhibits processes leading to pulse breakup while allowing spectral expansion to proceed as desired. We introduce basic criteria for setting the plate thickness or initial laser intensity and the location of each plate in the laser beam path and confirm that under these condi

Safe drinking water in a changing environment : Membrane filtration in a Swedish context

Surface water is vital for Swedish drinking water supply. In the past decades, a trend of increased total organic carbon (TOC) concentrations has led to higher consumption of coagulants in drinking water treatment, and has pushed the levels in the outgoing water closer to the allowed levels of TOC. Also, two occasions of cryptosporidium outbreaks in northern Sweden have stressed the importance of

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

Aims/hypothesis: Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming adipose tissue dysfunction in LBW individuals. Methods: ADSCs were isolated from the subcutaneous adipose tissue of 13 normal birthw