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We investigated cancer incidence between 1958 and 1995 in 1873 individuals belonging to 29 consecutively identified BRCA1 and 20 BRCA2 associated families from Southern Sweden using data from parish and local tax authorities, as well as the Swedish Cancer Registry, Cause of Death Registry and Census Registry. 150 malignant tumours were analysed from 1145 relatives in the BRCA1 families and 87 tumo
Ambiguous practices and identities of NGOs have become a source of increasing concern for all involved in development intervention. But apart from pointing at dishonest marketing and unfortunate unintended consequences of donors’ support, how can we understand these ambiguities? Based on an ethnographic study of local Bangladeshi NGOs, the article explores actions and behaviour of grassroots NGO s
To investigate the differential short-term effects of selective estrogen receptor (ER) modulators (SERMs) on uterus, we treated adult ovariectomized rats with a novel SERM, ospemifene (Osp), two previously established SERMs (tamoxifen and raloxifene (Ral)) and estradiol. The expression of two estrogen-regulated early response genes c-fos and vascular endothelial growth factor (VEGF), and DNA synth
One of the basic principles in the European policy to cope with the growing challenge of water scarcity is that water demand management should be considered before opting for additional water infrastructure. Die implication of this is that water must be treated as an economic good, which means that the "user's pays' principle" has to be implemented, At the same time there is much political consens
Ferrous sulfate (Fe(SO4)2) PVA gels were investigated for a range of absorbed doses up to 20 Gy using both magnetic resonance imaging (MRI) and spectrophotometry to determine R1 and optical density (OD) dose responses and G values. It was found that R1- and OD-dose sensitivities increased with O2 saturation or by the introduction of a freeze-thaw cycle during preparation of the PVA gel. The storag
Introduction and objective Misreporting fractures in questionnaires is known. However, the effect of misreporting on the association of fractures with subsequent health outcomes has not been examined. Methods Data from a fracture registry (FR) developed from an extensive review of radiographic and medical records were related to self-report of fracture for 2,255 participants from the AGES Reykjavi
The influence of the reaction parameters on the conversion of 3-picoline and the yield of nicotinonitrile in the ammoxidation of 3-picoline on a View the MathML source catalyst was studied. The highest yield of nicotinonitrile was 82%. This was obtained at 400 °C, with a space velocity of 4000 h−1 and the following mole ratios: ammonia/3-picoline = 12, air/3-picoline = 210, and water vapour/3-pico
The mechanism of hydrolysis of cellulose is important for improving the enzymatic conversion in bioprocesses based on lignocellulose. Adsorption and hydrolysis experiments were performed with cellobiohydrolase I (CBH I) and endoglucanase II (EG II) from Trichoderma reesei on a realistic lignocellulose substrates: steam-pretreated willow. The enzymes were studied both alone and in equimolar mixture
PROTEIOS is an initiative for the development of a comprehensive open source system for storage, organization, analysis and annotation of proteomics experiments. The PROTEIOS platform is based on commonly acknowledged principles for proteomics data publishing.
In this paper we use a simulation approach to explore the effect of variation in taxon parameters and landscape patterning on relevant source area of pollen. We use the Prentice-Sugita model, assume constant atmospheric conditions and basin morphology, and take a reductionist approach to explore the behaviour of pollen dispersal and deposition in a simple landscape scenario. Individual factors wit
Objectives: The purpose of this study was to design, validate, and optimize internally standardized real-time quantitative RT-PCR assays and to identify and avoid problems with assay reliability and examine the impact of an exogenous internal standard. Design and methods: The model system consisted of internally standardized quantitative real-time RT-PCR assays specific for PSA and hK2 mRNA based
This paper presents a study of supported lipid bilayer (SIB) formation and subsequent protein binding using a sensor that combines localized surface plasmon resonance (LSPR) and quartz crystal microbalance with dissipation (QCM-D) monitoring. The LSPR activity arises from silicon oxide (SiOx) coated nanometric apertures in a thin gold film, which also serves as the active electrode of a QCM-D crys
In the process of producing ethanol from lignocellulosic materials, compounds inhibitory to enzymatic hydrolysis and fermentation are generated during the pretreatment of the wood. In an industrial process, these compounds will accumulate due to the recirculation of process streams. The inhibitory effects of the accumulation of volatile and nonvolatile compounds released during stream pretreatment
Cadmium can be effectively removed from wet-process phosphoric acid (WPA) by solvent extraction using long-chain amines, preferably tertiary amines, as extractants. Stripping can be performed either with water or with acids such as phosphoric or sulphuric acid depending on the final conversion of the cadmium waste. Scrubbing could be necessary in some cases and can be performed with alkali. A fac
Genetic differentiation of Dactylorhiza majalis ssp. traunsteineri from the Alps, Scandinavia, and Britain was studied and compared with other allotetraploid members of the systematically challenging genus Dactylorhiza. One-hundred and eleven populations from altogether 18 taxa were analysed for eight polymorphic plastid markers and two size-variable fragments from the nuclear internal transcribed
The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with <500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-
