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The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class of protein-lipid complexes having broad spectrum anti-cancer, and some specific anti-bacterial properties. The structure of HAMLET-like compounds consists of an aggregation of partially unfolded protein making up the majority of the compound'

Aqueous mixtures of gamma-cyclodextrin (gamma-CD) and the thermosensitive cationic diblock copolymer poly(N-isopropylacrylamide)-b-poly(3-acrylamidopropyl)trimethylammonium chloride (PNIPAAM(24)-b-PAMPTAM(+)(9)) or the PNIPAAM homopolymer PNIPAAM(47) have been investigated using various experimental methods. Solid g-CD-polymer inclusion complexes (pseudopolyrotaxanes) form at ambient temperatures

The terminase motors of bacteriophages have been shown to be among the strongest active machines in the biomolecular world, being able to package several tens of kilobase pairs of viral genome into a capsid within minutes. Yet, these motors are hindered at the end of the packaging process by the progressive buildup of a force-resisting packaging associated with already packaged DNA. In this experi

Live-cell imaging of biological processes at the single cell level has been instrumental to our current understanding of the subcellular organization of bacterial cells. However, the application of time-lapse microscopy to study the cell biological processes underpinning development in the sporulating filamentous bacteria Streptomyces has been hampered by technical difficulties. Here we present a

In this chapter I will discuss the effects of agency loss, cultural trauma and healing, by focusing on the impact the boarding schools, the so called residential school, had and still has on contemporary Cana-dian Mi’kmaq Native identity, drawing on interviews from one of my fieldworks conducted on the island Cape Breton, Nova Scotia.

An increased use of forest fuels is important in the reduction of our dependence on fossil fuels and in attempting to mitigate climate change. However, an increased use will also result in an intensified forestry. Recovery of forest residues (logging residues and stumps) results in a higher pressure on the forest ecosystems and adds environmental effects to those already existing in conventional f

The Early Neolithic (c. 4000–3500 BC) site of Almhov, located in southwestern Scania, Sweden, is interpreted as a gathering and feasting site, subsequently transformed into a burial site with ancestral monuments. The focus of the article is on the pit pairs and pit clusters at the site, and on the dierential distribution of artefacts and animal bones within them, thereby touching upon more general

Thirty wild blue rock pigeons (Columba livia) were caught from Multan city (Pakistan). Hematological values were established for total red blood cells, total white blood cells, packed cell volume, hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and differential leukocyte count. Serum bio chemistry values were determined for

PURPOSE:: To study retinal function after vitrectomy. METHODS:: Core vitrectomy was performed in 12 rabbits under standardized conditions using a vitreous cutting rate of either 600 or 1200 cuts/min. Full-field electroretinography (ERG) and multifocal electroretinography (mfERG) were performed pre- and postoperatively. Morphologic change was monitored by immunohistochemistry directed against glial

Inorganic nutrient availability and temperature are recognized as major regulators of organic carbon processing by aquatic bacteria, but little is known about how these two factors interact to control bacterial metabolic processes. We manipulated the temperature of boreal humic stream water samples within 0-25 degrees C and measured bacterial production (BP) and respiration (BR) with and without i

ABSTRACT Aims: To examine associations between leisure time physical activity before and during pregnancy and preterm delivery, birth weight, and pre-eclampsia and to describe levels of physical activity prior to and during pregnancy. Furthermore to elucidate women’s experiences and views of leisure time physical activity during pregnancy in a qualitative study. Methods: Data sources were: the Aar

Popular Abstract in Swedish Graviditetsdiabetes är diabetes som uppkommer eller först upptäcks under en graviditet. Mellan 1-14 % av alla gravida kvinnor runt om i världen drabbas av graviditetsdiabetes och i Sverige är det ungefär 2 %. I Sverige behandlas graviditetsdiabetes med kostråd och om detta inte räcker lägger man till insulinbehandling. Kända riskfaktorer för att utveckla graviditetsdiabGestational diabetes mellitus (GDM) occurs as a complication in 2% of all pregnancies in Sweden. Women with GDM have a substantial risk of developing type 2 diabetes later in life, but the risk of developing type 1 diabetes is also increased. GDM increases the risk for macrosomia and caesarean delivery. However, long term prognosis and eventual future risks for children born to mothers with a prev

Ca(Fe1-xCox)(2)As-2 single crystals with concentration x = 0.032, 0.051, and 0.063 were investigated by means of neutron diffraction under hydrostatic pressure. The region of existence of the high-temperature tetragonal, low-temperature orthorhombic, and pressure-induced collapsed tetragonal phases have been determined and the corresponding p-T phase diagrams for the three compositions have been c

Changes in the structure and function of the small airways (<2 mm diameter) are now recognized to play a major role in airflow limitation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Increased thickness of the small airway wall causes lumenal narrowing; which can be further occluded by mucus and/or inflammatory cell exudate. This leads to increased peripheral resistance,

Gradient based nuclear magnetic resonance spectroscopy provides a convenient method to determine self-diffusion coefficients especially in liquid samples. The method has many advantages including short experiment time, sensitivity, molecular resolution, and accuracy - all without the need for adding perturbing probes or chemically introducing isotopes. In this contribution we introduce the method