AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged

Secretory leukocyte protease inhibitor (SLPI) is a well-known protease inhibitor. Its function is thought to be protease/protease-inhibitor balance. Free proteolytic activity, mainly pancreatic elastase, anionic trypsin and granulocytic elastase, has been demonstrated in faecal extracts from patients with ulcerative colitis. We wanted to verify that SLPI is actually secreted from normal human colo

This paper explores the current role of mindfulness in sustainability science, practice, and teaching. Based on a qualitative literature review that is complemented by an experimental learning lab, we sketch the patterns and core conceptual trajectories of the mindfulness–sustainability relationship. In addition, we assess this relationship within the field of climate change adaptation and risk re

Ten ileal T-cannulated pigs (19.26 ± 1.06 kg) were used to evaluate the effects of a novel Buttiauxella phytase on apparent ileal digestibility (AID) of AA and apparent total tract digestibility (ATTD) and hindgut disappearance of DM, GE, CP, crude fiber, NDF, and ADF as well as minerals balance. Pigs were fed in a duplicated 5 × 4 incomplete Latin square design (5 diets with 4 periods). Each peri

China and India, two countries with skewed sex ratios in favor of males, have introduced a wide range of policies over the past few decades to prevent couples from deselecting daughters, including criminalizing sex-selective abortion through legal jurisdiction. This article aims to analyze how such policies are situated within the bio-politics of population control and how some of the outcomes ref

Delvenne et al. present theoretical considerations about the pedagogy of technology assessment (TA) in general and the summer school format in particular, which was chosen as a platform for teaching TA in the PACITA project. The PACITA summer school programme was designed to encourage the uptake and use of TA rationale and methods by various types of professionals involved in science, technology o

Review of Avner Offer & Gabriel Söderberg, The Nobel Factor

Recently interest has been focused on secretory leucocyte protease inhibitor (SLPI) and its role in immediate hypersensitive reactions, possibly by inhibiting mast cell chymase. The purpose of this investigation was to show whether or not SLPI is produced in mast cells. Double-immunolabelling revealed that SLPI coexists with mast cell tryptase (60%) and chymase (37%). On the other hand, in situ hy

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study.

This paper presents a cylindrical multipole expansion for periodic sources with applications for three-phase power cables. It is the aim of the contribution to provide some analytical solutions and techniques that can be useful in the calculation of cable losses. Explicit analytical results are given for the fields generated by a three-phase helical current distribution and which can be computed e

Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cells (Tregs). Using a murine model of ITP, we analyzed Tregs in the spleen and thymu

T-helper 1 polarization in patients with primary immune thrombocytopenia (ITP) is well documented. However, the genetic contribution to this imbalance remains unclear. To address this question, we selected six candidate single nucleotide polymorphisms within cytokine or cytokine receptor genes for association testing among Caucasian adults. Patients from the United Kingdom Adult ITP Registry were

In this paper a multichannel subspace detector is proposed based on a separable spatio-temporal linear model. The generalized likelihood ratio test (GLRT) for this model is derived for the case of coloured Gaussian noise and known temporal and covariance matrices. Simulation results support the theory and illustrate the benefits of the spatio-temporal detector versus channel-by-channel detectors f

In Information Gap Decision Theory (IGDT) a system is said to be robust to uncertainty if specified goals are achieved with satisfaction despite large info-gaps. Under this theory an info-gap expresses the disparity between what is known and unknown in structures for which uncertainty is judged as severe. We discuss how robustness in IGDT can be merged with a perspective on risk which allows for d

In the words of Wehner (J Comp Physiol A 161:511–531, 1987) who first coined the term “matched filter” in the context of sensory systems, matched filters “severely limit the amount of information the brain can pick up from the outside world, but they free the brain from the need to perform more intricate computations to extract the information finally needed for fulfilling a particular task”. In o