A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of ageing. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to ageing. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. We

Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptor

Remodeling of a bone graft can be influenced both by anabolic substances, such as a bone morphogenic protein (BMP) and by anticatabolic substances, such as the bisphosphonates. BMPs are potent bone anabolic substances, but also boost catabolism and cause resorption. Bisphosphonates inhibit osteoclast function and can be used to postpone resorption. In the present study a combination of both drugs

The ideological (re)construction of the position of Swedish in Finland is examined as it took shape during a major year-long debate about the role of Swedish in Finnish education. Data were collected through archival research of the leading national newspapers in the two official languages of Finland: Helsingin Sanomat (Finnish) and Hufvudstadsbladet (Swedish). Circulating and intersecting discour

In-situ x-ray tomography has been used to follow deformation processes in 3D during two triaxial compression tests, one on a specimen of bio-cemented Ottawa 50-70 sand and the other on a specimen of the non-cemented sand. The global stress-strain responses show that the bio-cementation process increases the shear strength (peak deviator stress is approximately doubled), and causes the material to

A dramatic increase in prevalence of pediatric obesity has occurred in most countries over the past few decades. This is of particular significance given the fact that overweight children and adolescents are at increased risk for multiple medical co-morbidities, as well as psychosocial and behavioral difficulties. While considerable attention has recently been paid to identifying obesity and the i

BACKGROUND: Cerebrospinal fluid (CSF) biomarkers and quantitative EEG show particular patterns of change in Alzheimer's disease (AD) and reflect neuropathologic processes and cerebral function, respectively. The changes precede cognitive decline and should be visible already in preclinical stages. We therefore aimed to investigate their relationship in cognitively healthy individuals. METHOD: Thir

Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing.

Greater blood pressure reactivity to psychological stress has been associated with higher risk of developing hypertension. We hypothesised that low stress resilience based on psychological assessment early in life is associated with hypertension in adulthood.

A comparison of scanning mobility particle sizer (SMPS) and laser-induced incandescence (LII) measurements of diesel particulate matter (PM) was performed. The results reveal the significance of the aggregate nature of diesel PM on interpretation of size and volume fraction measurements obtained with an SMPS, and the accuracy of primary particle size measurements by LII. Volume fraction calculatio

The Internet constitutes a heterogeneous mesh of networks with highly varying characteristics. One of the features of this environment is that there normally are a number of possible paths for data to travel between two end-hosts. These different paths exhibit highly different properties in terms of bandwidth, delay, reliability etc. One of the challenges in this environment is to map the properti

This article reports on case studies of eight Swedish based European Works Councils (EWCs) with a particular focus on impacts and outcomes. Three issues are explored: a) the benefits of EWCs from both employee and management perspectives; b) whether the EWCs have evolved as genuine forums for information, consultation and negotiation; and c) the effects of EWCs on industrial relations systems – sp

In identifying a bias within situated learning theory towards routine work practices, this paper develops a theoretical framework for assessing the relationships between learning, sensemaking and power in the non-routine practices of temporary organising. The paper locates processes of sensemaking and learning in a model of organisational change that attempts to render power in communities of prac

Is the high plateau in a ‘hat pattern’ a phonetic artefact, or does it reflect a phonological feature? Can it contrast with a low plateau, i.e., a ‘dip pattern’? The presented perception experiment supports the phonological point of view, since it shows that the dip/hat contrast can disambiguate German oder-constructions, which are interpretable as ‘alternative’ or ‘yes/no-questions’. This specifi

The aim of this paper is to present trends, similarities and differences in the usage of graphical languages at the level of Process Control, manufacturing Operations and Business Systems. The paper also gives ideas of how a common language could be used to increase the integration between the three levels and what advantages this could bring to its user.