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Cytokines and Janus kinase/signal transducer and activator of transcription signaling in prostate cancer : overview and therapeutic opportunities

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originally identified as a key cellular mechanism mediating the action of cytokines, interferons, and growth factors for the control of gene expression. Extracellular signals mediated by cytokines are thus transduced through this pathway into transcriptional programs that regulate cell growth, differentiatio

Improved usability of pedestrian environments after dark for people with vision impairment : An intervention study

Walking is an important transport mode for sustainable cities, but the usability of pedestrian environments for people with impaired vision is very limited after dark. This study compares the usability of a walkway, operationalized in terms of (i) the pedestrian's ability to orient themselves and detect infrastructure elements, and (ii) the perceived quality of lighting in the environment (evaluat

The transformation by catalysis of prebiotic chemical systems to useful biochemicals : A perspective based on IR spectroscopy of the primary chemicals: I. the synthesis of peptides by the condensation of amino acids

It is now widely speculated that life originated at the "Black Smokers" of the undersea hydrothermal vents, where conditions exist for the formation of the primary ingredients and their subsequent transformation to higher biotic species such as amino acids, alcohols, etc. Any possible routes for the prebiotic oligomerization of simple compounds like amino acids, necessary for cell formation, has s

Young men's behavioral competencies and risk of alcohol use disorder in emerging adulthood : Early protective effects of parental education

We investigate how early exposure to parental externalizing behaviors (EB) may contribute to development of alcohol use disorders (AUD) in young adulthood, testing a developmental cascade model focused on competencies in three domains (academic, conduct, and work) in adolescence and emerging adulthood, and examining whether high parental education can buffer negative effects of parental EB and oth

Striving Towards a Holistic Innovation Policy in European Countries - But Linearity Still Prevails!

The concept of a holistic innovation policy is defined in this article, with discussions of what it is, why it is relevant, and how it can be implemented to enhance product innovation. It is shown that the innovation systems approach has diffused rapidly during the latest decades and has completely replaced the linear view in the field of innovation research. The majority of European countries are

The Choice of Innovation Policy Instruments

The purpose of this article is to discuss the different types of instruments of innovation policy, to examine how governments and public agencies in different countries and different times have used these instruments differently, to explore the political nature of instrument choice and design (and associated issues), and to elaborate a set of criteria for the selection and design of the instrument

Automatisk skadeklassning av lovtrad i stadsbebyggelse med hjalp av digitaliserade IR-fargflygbilder

In August 1986 some parks in central Malmo were photographed from a height of 760 meters with colour infrared film. Two simultaneous studies were performed to evaluate the feasibility of manual and digital classification of trees with different degrees of crown damage. This damage is mostly due to exhaustion fumes from heavily trafficked roads, mechanical damage to roots and de-icing salt. This pa

Can patch testing with methylchloroisothiazolinone/methylisothiazolinone be optimized using a new diagnostic mix? – A multicenter study from the Swedish Contact Dermatitis Research Group

Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods:

Measurement of Λ (1520) production in pp collisions at √s=7TeV and p–Pb collisions at √sNN=5.02TeV

The production of the Λ (1520) baryonic resonance has been measured at midrapidity in inelastic pp collisions at s=7TeV and in p–Pb collisions at sNN=5.02TeV for non-single diffractive events and in multiplicity classes. The resonance is reconstructed through its hadronic decay channel Λ (1520) → pK - and the charge conjugate with the ALICE detector. The integrated yields and mean transverse momen

Life Satisfaction in Persons With Late Effects of Polio : A Test-Retest Reliability Study

Background: The Life Satisfaction Questionnaire (LiSat-11), including one global item and 10 domain-specific items, is used to evaluate life satisfaction in persons with the late effects of polio (LEoPs). However, there is a lack of knowledge about its psychometric properties. Objective: To evaluate the test-retest reliability of the LiSat-11 and the associations between the global and domain-spec