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Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
PurposeGermline genetic testing for BRCA1 and BRCA2 variants has been a part of clinical practice for >2 decades. However, no studies have compared the cancer risks associated with missense pathogenic variants (PVs) with those associated with protein truncating (PTC) variants.MethodsWe collected 582 informative pedigrees segregating 1 of 28 missense PVs in BRCA1 and 153 pedigrees segregating 1 of
SELNET clinical practice guidelines for soft tissue sarcoma and GIST
Results of the COVID-19 mental health international for the general population (COMET-G) study
‘Roi d’Angleterre’ and ‘Le Pretendant’ : A Cultural Semiotic Approach to the Use of Titles by Swedish Diplomats, 1715-1717
Deeply lonely in the borderland between childhood and adulthood - Experiences of existential loneliness as narrated by adolescents
Background: Adolescence is associated with different feelings and experiences that can negatively affect adolescents’ health and well-being. In the transition between childhood and adulthood, experiences of loneliness are common. A deep form of loneliness is described as existential loneliness. Studies among adults have shown that existential loneliness often arises in connection with transitions
Tacitus Annales
"Of the Finest Quality" : The Swedish Diplomats’ role within global consumption 1710-1740
Sub-cycle high-order nonlinearities in a free-running terahertz semiconductor laser
Field-resolved two-dimensional spectroscopy reveals the sub-cycle gain dynamics of a free-running terahertz quantum cascade laser and disentangles resonantly enhanced nonlinearities up to eight-wave mixing in a regime where gain replaces absorption.
(O)möjligheter : Den papperslösa diplomaten Carl Gyllenborgs agens 1715
Professionaliseringen av diplomatin skedde genom en lång process vars start ofta placeras vid slutet av den Westfaliska freden och 1700-talets slut. Denna professionaliseringsprocess var komplex eftersom den formades av de aktiva diplomaterna, deras livserfarenheter, och av tidsspecifika normer förankrade i ritualer och dokumentation, samt därtill av förändringar kopplade till allt tydligare socia
Enabling Decentralized Computation of the WAX Decomposition
As the number of antennas scales up, research efforts have been directed towards finding decentralized receiver solutions for multi-antenna architectures. In a recent paper, a novel matrix decomposition - the WAX decomposition - was proposed, which has direct bearing on characterizing the level of decentralization that is possible if the complexity of the decentralized processing is limited. Howev
Solar access indicators for urban planning
Solar access describes the amount and distribution of sunlight in living environments. Access to sunlight is crucial for the health and sustainability of cities. It is vital for people and vegetation, and for energy production and conservation. The amount of sunlight entering the city space is restricted by the urban layout, as buildings obstruct solar access by shading each other and the surround
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
Editorial : Methods and applications in inflammation pharmacology
Editorial : Extracellular matrix in homeostasis and cancer
The European Solar Telescope
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Sw
Infrared Drying Characteristics and Quality Variations of Lily Bulbs Under Blanching Pretreatment
Infrared drying characteristics and quality variations (color change, hardness, contents of polyphenol and flavonoid) of lily bulbs under blanching pretreatment are investigated. Influences of parameters such as pretreatment temperature and time and infrared drying temperature are discussed. Effective moisture diffusivity coefficient, activation energy, and energy consumption were calculated. Resu
The effect of regular, low-dose, sustained-release morphine on routine physical activity in people with persistent breathlessness : a hypothesis-generating study
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients
Hippocampal subregional thinning related to tau pathology in early stages of Alzheimer’s disease
Background: Subregions in the medial temporal lobe (MTL) are affected early by Alzheimer’s disease (AD) pathology and subject to grey matter atrophy. Measuring the earliest AD-related atrophy in the hippocampus is challenging as region-of-interest (ROI) analyses of hippocampal subregional volumes collapse across voxels within anatomical subregions. PET imaging studies, however, report accumulation