Tumor Control Probability and Small-Scale Monte Carlo Dosimetry : Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy
In radiopharmaceutical therapy, intratumoral uptake of radioactivity usually leads to heterogeneous absorbed dose distribution. The likelihood of treatment success can be estimated with the tumor control probability (TCP), which requires accurate dosimetry, estimating the absorbed dose rate per unit activity to individual tumor cells. Methods: Xenograft cryosections of the prostate cancer cell lin