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Ta din tid : Gör mindre men bättre

Hur får man tid över till det viktigaste?Hur kan du åstadkomma mer och bättre genom att göra mindre?Samtidshistorikern David Larsson Heidenblad har grävt, sorterat och testat för att kunna lyfta fram de mest välgrundade och effektiva metoderna och principerna – för den som vill koncentrera sig på det väsentliga i livet.Med hjälp av dessa – och andra tips och råd – hjälper han läsaren att klart och

Sum rules and physical bounds for a particulate slab --- transmission

Two different sum rules for transmission of the coherent electromagnetic field by a particulate slab are established. The particles are assumed spherical and randomly located, and the slab is illuminated by a plane wave at normal incidence. These sum rules are obtained assuming the particles are passive scatterers, and satisfy energy conservation and causality conditions. The sum rules are then emTwo different sum rules for transmission of the coherent electromagnetic fieldby a particulate slab are established. The particles are assumed sphericaland randomly located, and the slab is illuminated by a plane wave at normalincidence. These sum rules are obtained assuming the particles are passivescatterers, and satisfy energy conservation and causality conditions. The sumrules are then employe

What happened in the hinterland? : A batch study of early bucket-shaped pots from the 4th and 5th centuries AD in Southwest Norway.

Rogaland in southwest Norway was a core production area for bucket-shaped pottery throughout the ca. 200-year period spanned by these finds. Largely thanks to Elna Siv Kristoffersen's work we have a well-developed understanding of the final century of this characteristic Migration Period find: certain ceramic craft networks rose to prominence, culminating in workshop milieux intimately tied to the

Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation

Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28), and he

Chicumbane Connections: Lower Limpopo Valley During the First Millennium AD.

Abstract The discussion of the transition to farming in southern Africa and the formation of Early Iron Age society, referred to in Mozambican archaeology as the Early Farming Communities (EFC), is complicated by the lack of surveys in key areas of intensive contacts. This article presents the results of excavations at the EFC site Chicumbane in the eastern lower Limpopo Valley, dated 500–800 AD. The discussion of the transition to farming in southern Africa and the formation of Early Iron Age society, referred to in Mozambican archaeology as the Early Farming Communities (EFC), is complicated by the lack of surveys in key areas of intensive contacts. This article presents the results of excavations at the EFC site Chicumbane in the eastern lower Limpopo Valley, dated 500–800 AD. The varia

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platele

Infrastructural considerations of implementing gene therapy for hemophilia in the Nordic context

Background: Despite improvements in hemophilia care, challenges remain, including treatment burden and impaired quality of life. Gene therapy may overcome these. However, its introduction presents a challenge. Objectives: To outline a function-based gene therapy working model describing critical milestones associated with gene therapy handling, administration, and follow-up to facilitate and imple

Access to informal venture capital and ambitious entrepreneurship – cross-country evidence

Many empirical studies have emphasized the importance of institutional venture capital for enabling high growth entrepreneurship and innovation. Yet, there are reasons to believe that provision of informal venture capital will have as significant, if not more significant effect on entrepreneurship. Based on Global Entrepreneurship Monitor data for 33 countries for the years 2001-2010, we study the

Two-year MRI-defined structural damage and patient-reported outcomes following surgery or exercise for meniscal tears in young adults

Objective: To investigate potential differences in structural knee joint damage assessed by MRI and patient-reported outcomes (PROMs) at 2-year follow-up between young adults randomised to early surgery or exercise and education with optional delayed surgery for a meniscal tear. Methods: A secondary analysis of a multicentre randomised controlled trial including 121 patients (18-40 years) with an

Refining the Definition of Stage 1 Type 1 Diabetes : An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity

OBJECTIVE To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddl

A self-managed exercise therapy program for wrist osteoarthritis : study protocol for a randomized controlled trial

Background: Post-traumatic wrist osteoarthritis (OA) can eventually lead to pain, muscular weakness, and stiffness of the wrist, which can affect the function of the entire upper limb and reduce the quality of life. Although there is strong evidence that all patients with OA should be offered adequate education and exercises as a first-line treatment, an effective self-management program, includin

Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer

Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [fIVIM]

Band termination spectroscopy in 157Er

The level scheme of 157Er has been extended from a spin region where the nucleus behaves as a prolate rotor to a region where the spin is produced by the alignment of all or most of the available valence nucleons along the symmetry axis of a weakly deformed oblate shape. The level scheme was established at high spin using up to four-fold gamma -ray coincidences detected in the Eurogam spectrometer

Comparative study of superdeformed and highly deformed bands in the [Formula Presented] mass region

Superdeformed and highly deformed rotational bands in the [Formula Presented] mass region are studied within cranked relativistic mean field theory and the configuration-dependent cranked Nilsson-Strutinsky approach. Both approaches describe the experimental data well. Low values of the dynamic moments of inertia [Formula Presented] compared with the kinematic moments of inertia [Formula Presented

Digital Papillary Adenocarcinoma in Nonacral Skin : Clinicopathologic and Genetic Characterization of 5 Cases

Digital papillary adenocarcinoma (DPA) is a rare sweat gland neoplasm that has exceptionally been reported outside acral locations. Recently, human papillomavirus 42 was identified as the main oncogenic driver of DPA. Herein, we report 5 tumors arising in extra-Acral locations predominantly in the female anogenital skin. Four patients were female and 1 patient was male. The mean age at the diagnos

Stable triaxiality at the highest spins in 138Nd and 139Nd

The nuclei 138Nd and 139Nd have been studied at very high spins via the 48Ca+94Zr reaction. Several new rotational bands were observed, four in 138Nd and two in 139Nd. The J(2) moments of inertia calculated from the observed γ-ray energies are very small and almost constant, indicating that these bands are triaxial. Cranked Nilsson-Strutinsky calculations reproduce the general behavior of the band