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CLC- a novel susceptibility gene for allergic rhinitis?

P>Background: Studies of the nasal lavage fluid proteome have previously identified proteins differently expressed in patients with symptomatic allergic rhinitis, e.g. S100A7, prolactin-inducible protein (PIP), wingless-type MMTV integration site family, member 2B (WNT2B), Charcot-Leyden crystal protein (CLC) and palate lung nasal epithelial clone (PLUNC). The aim of the present study was to inves

The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the Functional Diversity of Eukaryotic Life in the Oceans through Transcriptome Sequencing.

Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.

Critical conditions for onset of mould growth under varying climate conditions

A performance-based service life design format based on climatic exposure on one hand and "resistance" of materials against mould growth on the other hand, is presented in this paper. A limit state for onset of mould growth is defined as the occurrence of traces of mould observed by microscopy. A dose-response model is proposed by which onset of mould growth can be predicted for an arbitrary clima

Luminescence properties of monoclinic Cu4I4(Piperidine)(4)

A new modification of Cu(4)I(4)Pip(4) has been synthesized under hydrothermal conditions. X-ray crystallography revealed that this compound crystallized in the monoclinic system and consists of a tetrahedral core with composition Cu4I4, in which each Cu atom is coordinated by a piperidine molecule via the N atom. In contrast to a previously reported modification of Cu(4)I(4)Pip(4), the present mod

Safety Work with an Ethnic Slant

Ethnic discrimination in the criminal justice system is a well-researched topic, but the significance of ethnicity in policing activities at more mundane levels has attracted less attention. This article analyzes ethnographic data on municipal ‘safety work’ in a Swedish city troubled with robberies, vandalism, and violence. It shows how the efforts of different safety workers, operating to curb cr

Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to Parkinso

Formation of solid organic nanoparticles from a volatile catanionic microemulsion

A novel volatile microemulsion formed by the catanionic surfactant hexadecyltrimethylammonium octylsulfonate (TA(16)So(8)), heptane and water has been explored as a template for producing nanoparticles of hydrophobic organic materials. Butylated hydroxytoluene (BHT) was employed as the model hydrophobic substance. First, the oil-in-water microemulsion was formed, containing TA16So8 as the single e

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,1

Participation in physical activity in relation to different life-change events

Regular physical activity is understood to be an essential prerequisite for human health for both psychological and physiological well-being. However, there are differences in participation in physical activity among different groups in society, and participation in physical activity can also change over a lifetime. The general aim of this thesis was to investigate how different life-change events

Impact of cognitive and linguistic ability on gaze behavior in children with hearing impairment.

In order to explore verbal-nonverbal integration, we investigated the influence of cognitive and linguistic ability on gaze behavior during spoken language conversation between children with mild-to-moderate hearing impairment (HI) and normal-hearing (NH) peers. Ten HI-NH and 10 NH-NH dyads performed a referential communication task requiring description of faces. During task performance, eye move

Constructing interorganizational collaboration The action researcher as boundary subject

This article aims to explore critically the role of an action research team in the social construction of interorganizational collaboration aimed at transgressing organizational and professional boundaries. We argue that the new relationships, actor conceptions and in some cases forms of work organization arising from the change process have been socially constructed through the discursive interve

Multi-agent source seeking via discrete-time extremum seeking control

Recent developments in extremum seeking theory have established a general framework for the methodology, although the specific implementations, particularly in the context of multi-agent systems, have not been demonstrated. In this work, a group of sensor-enabled vehicles is used in the context of the extremum seeking problem using both local and global optimisation algorithms to locate the extrem

Assessment of quality of life in lymphedema patients: validity and reliability of the Swedish version of the Lymphedema Quality of Life Inventory (LQOLI)

The Lymphedema Quality of Life Inventory (LQOLI) is an instrument developed for patients with different types of lymphedema. It contains physical, emotional, social, and practical dimensions and consists of 58 items, each with three sub items concerning life quality, daily life changes, and difficulties of changing and two items concerning life quality in general and in relation to lymphedema. The

Time lags in biodiversity response to farming practice

Agri-environmental schemes have been applied with the goal to mitigate negative effects of agriculture on biodiversity and ecosystem functioning. However, on evaluating the schemes the results have been variable and shown both positive and neutral effects. These variable effects can be attributed to not taking into account important factors affecting the variables at test, such as biodiversity. Th

On Stern-Gerlach coincidence measurements and their application to Bell's theorem

We analyze a coincidence Stem-Gerlach measurement often discussed in connection with the derivation and illustration of Bell's theorem. The treatment is based on our recent analysis of the original Stern-Gerlach experiment [H. Wennerstrom and P.-O. Westlund, Phys. Chem. Chem. Phys. 14, 1677 (2012)1, where it is concluded that it is necessary to include a spin relaxation process to account for the