Filetype
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channe
Background: Due to increasing globalization and Internet communication, the number of international marriages has increased. In Sweden, 75% of the Thai population are women, among whom 80% are partnered with Swedish or other Scandinavian men. Previous studies have indicated that lack of autonomy, social isolation, and stigma are important risk factors for poor mental health for foreign-born women
This paper contributes to the literature on urban climate change experiments by analysing ascribed advantages and challenges of organizing climate change experiments at the urban scale, and by examining how local actions translate into effect. We here distinguish between effects of experiments in achieving actual sustainability gains (‘goal-oriented objectives’) and instigating broader institution
Tillitsbaserad styrning och ledning (TSL) är en samling metoder som syftar till att öka kvaliteten i offentligt finansierade tjänster genom att öka tilliten till brukare och brukarmötande yrkesgrupper. Dessa metoder har utvecklats som svar på en växande kritik mot utvecklingen i den offentligt finansierade välfärdssektorn under senare år, bland annat en växande administrativ börda, stelbenta struk
Uterine fibroids are the most common tumors of the uterus and the female pelvis and are associated with substantial morbidity for several women. In women with a wish to preserve fertility, a myomectomy is the surgical procedure of choice when medical therapy is inadequate. Despite evidence that minimally invasive surgery is preferable to laparotomy, most myomectomies are still performed by laparot
Background: The life expectancy of pancreatic cancer patients remains minimal. The disease progression may be influenced by type 2 diabetes (T2D) and inflammatory status, although important gaps persist around their joint effects on disease outcome. The aim of this study was to investigate the clinical significance of the tumour immune microenvironment on pancreatic cancer prognosis in relation to
