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Associations of anthropometric factors with KRAS and BRAF mutation status of primary colorectal cancer in men and women : a cohort study

Obesity is a well-established risk factor for colorectal cancer (CRC), and accumulating evidence suggests a differential influence of sex and anthropometric factors on the molecular carcinogenesis of the disease. The aim of the present study was to investigate the relationship between height, weight, bodyfat percentage, waist- and hip circumference, waist-hip ratio (WHR), body mass index (BMI) and

Late-Onset Hypogonadism and Mortality in Aging Men

Context: Late-onset hypogonadism (LOH) has recently been defined as a syndrome in middle-aged and elderly men reporting sexual symptoms in the presence of low T. The natural history of LOH, especially its relationship to mortality, is currently unknown. Objective: The aim of this study was to clarify the associations between LOH, low T, and sexual symptoms with mortality in men. Design, Setting, a

Like-charge attraction in a slit system: pressure components for the primitive model and molecular solvent simulations

We have recently reported Monte Carlo simulations for a system of two infinite like-charged plates in a dipolar fluid solvent (Pegado et al 2008 J. Chem. Phys. at press). The pressure as a function of plate separation qualitatively reproduces the ion-ion correlation attraction picture seen in primitive model studies, where the solvent only enters the picture implicitly through its dielectric const

Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease

P>Overactivity of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors is implicated in the pathophysiology of l-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we evaluated the behavioural and molecular effects of acute and chronic blockade of Ca2+-permeable AMPA receptors in animal models of PD and LID. The acute effects of the Ca

Quantification of mineral behavior in four dimensions: Grain boundary and substructure dynamics in salt

Here we present the first four dimensional (time and three dimensional space resolved) experiment on a strongly deformed geological material. Results show that even complicated microstructures with large continuous and discontinuous changes in crystallographic orientation can be resolved quantitatively. The details that can be resolved are unprecedented and therefore the presented technique promis

Quantitative disease resistance: to better understand parasite-mediated selection on major histocompatibility complex.

We outline a descriptive framework of how candidate alleles of the immune system associate with infectious diseases in natural populations of animals. Three kinds of alleles can be separated when both prevalence of infection and infection intensity are measured-qualitative disease resistance, quantitative disease resistance and susceptibility alleles. Our descriptive framework demonstrates why all

Swim pacemakers in box jellyfish are modulated by the visual input.

A major part of the cubozoan central nervous system is situated in the eye-bearing rhopalia. One of the neuronal output channels from the rhopalia carries a swim pacemaker signal, which has a one-to-one relation with the swim contractions of the bell shaped body. Given the advanced visual system of box jellyfish and that the pacemaker signal originates in the vicinity of these eyes, it seems logic

Towards More Coherent and Sustainable Biomass Policy: Examining European biomass-to-energy planning

Popular Abstract in Swedish Mot en sammanhållen och hållbar biomassapolitik: En studie av europeisk biomassa-för-energi-planering Biomassa används för många ändamål. När den används som biobränsle för att producera energi utgör den en förnybar energikälla med många fördelar, bl. a. i form av minskade utsläpp av växthusgaser och en ökad trygghet i energiförsörjningen. Men biomassa är även en råvaCoordination of policies embracing biomass use has been called for in order to speed up progress towards the European Union renewable energy and climate change goals. Policy coordination and coherence is also required if the many complex and diverse issues constraining sustainable bioenergy development are to be addressed. To contribute to meeting such needs this doctoral thesis provides insights

Integrating Climate Change Adaptation into Disaster Risk Reduction in Urban Contexts: Perceptions and Practice

This paper analyses the perceptions of disaster risk reduction (DRR) practitioners concerning the on-going integration of climate change adaptation (CCA) into their practices in urban contexts in Nicaragua. Understanding their perceptions is important as this will provide information on how this integration can be improved. Exploring the perceptions of practitioners in Nicaragua is important as th

A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients

The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maxim

Opposite Patterns of Diurnal Activity in the Box Jellyfish Tripedalia cystophora and Copula sivickisi

Cubozoan medusae have a stereotypic set of 24 eyes, some of which are structurally similar to vertebrate and cephalopod eyes. Across the approximately 25 described species, this set of eyes varies surprisingly little, suggesting that they are involved in an equally stereotypic set of visual tasks. During the day Tripedalia cystophora is found at the edge of mangrove lagoons where it accumulates cl

Development of amperometric immunoassays (AIAs) for calpastatin and mu-calpain with possible applications in the biomedical field

Due to the involvement of calpains and calpastatin in the pathology of several diseases, it is important to create an analytical tool for their accurate and sensitive measurements. In this work, an amperometric immunoassay (AIA) was developed and optimized for quantification of two key proteins from the calpain proteolytic system. The detection is based on the measurement of a steady-state current

I vilken utsträckning kan elcyklar (och elmopeder) ersätta dagens biltrafik?

Gruppen om använder elcykel är enligt datamaterialet främst män med tillgång till bil. Innehavet är ganska jämnt fördelat över 35 år. Elcyklisterna är teknikintresserade samtidigt verkar miljöintresset vara ett drivande motiv till varför elcykel införskaffades. Minskad restid verkar ha en viss betydelse speciellt för den yngre åldersgruppen. Majoriteten av de svarande instämmer i påståendet att el

The skeletal phenotype of chondroadherin deficient mice.

Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Additionally, the protein acts as an anchor to the matrix by binding tightly to collagens type I and II as well as type VI. We generated mice with inactiv

Motorcyclists’ road safety related behavior at access points on primary roads in Malaysia – A case study

An observational study, focusing on motorcyclists, was conducted between June and August 2012 at access points on straight road sections of primary roads in Malaysia. This was done in order to gain more insight into the actual road traffic situation at these sites. The majority of the motorcyclists kept to the speed limit and lowered speed when approaching an access point, especially when road use

Women's experiences of sexual health when living with Rheumatoid Arthritis - an explorative qualitative study

Background: The ICF core sets for patients with Rheumatoid Arthritis ( RA) acknowledge sexual function and intimate relationships as important since the patients' sexual health can be affected by the disease. About 36-70% of all RA-patients experience a reduced sexual health, and their perceived problems are directly or indirectly caused by their disease. Physiotherapy is often used as non-pharmac

Major complications during negative pressure wound therapy in poststernotomy mediastinitis after cardiac surgery

Objective: Negative pressure wound therapy is the first-line treatment modality for poststernotomy mediastinitis in many heart centers. The aim of this study was to analyze major complications and possible preventive methods during negative pressure wound therapy in patients with deep sternal wound infections. Methods: We retrospectively analyzed 69 consecutive patients treated with negative press