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Preparation of human dihydroorotate dehydrogenase for interaction studies with lipid bilayers

Human dihydroorotate dehydrogenase (DHODH) is an integral protein of the inner mitochondrial membrane (IMM) that catalyzes the fourth step of the de novo pyrimidine biosynthesis and is functionally connected to the respiratory chain via its lipophilic co-substrate, ubiquinone Q10. DHODH is the target for drugs approved for the treatment of rheumatoid arthritis and multiple sclerosis, and mutations

Anti-phospholipid antibodies and renal involvement are the main features associated with adverse pregnancy outcomes in patients with Systemic Lupus Erythematosus. A long-term longitudinal study in Southern Sweden

Background Systemic Lupus Erythematosus (SLE) affects mostly women in childbearing age. Modern management of SLE patients has improved the pregnancy outcomes over the last decades. However, there is still an increased risk of maternal, fetal and neonatal complications. In this longitudinal follow-up of pregnant women affected by SLE, we aimed to investigate which clinical and immunological feature

Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors

Summary: We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were at increased risk of impaired bone health. Prevention of osteoporosis should be considered in their follow-up. Introduction: Childhood cance

Ultra-High Dose Rate (FLASH) Radiotherapy : Silver Bullet or Fool's Gold?

Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating a better tumor response. Initial pre-clinical studies have shown that irradiation at dose rates far exceeding those currently used in clinical con

Structural Factors Responsible for Universal Health Coverage in Low- and Middle-Income Countries : Results From 118 Countries

Background: Demography, politics, economy, and governance appear to be the major structural factors for health and well-being. These factors have a significant role to play in achieving universal health coverage (UHC). The majority of previous studies did not highlight those factors. The aim of this study is to explore the basic structural factors (political stability, demography, gross national i

Electron-Magnon Coupling and Nonlinear Tunneling Transport in Magnetic Nanoparticles

We present a theory of single-electron tunneling transport through a ferromagnetic nanoparticle in which particle-hole excitations are coupled to spin collective modes. The model employed to describe the interaction between quasiparticles and collective excitations captures the salient features of a recent microscopic study. Our analysis of nonlinear quantum transport in the regime of weak couplin

Theory of Tunneling Spectroscopy in a Mn12 Single-Electron Transistor by Density-Functional Theory Methods

We consider tunneling transport through a Mn12 molecular magnet using spin density functional theory. A tractable methodology for constructing many-body wave functions from Kohn-Sham orbitals allows for the determination of spin-dependent matrix elements for use in transport calculations. The tunneling conductance at finite bias is characterized by peaks representing transitions between spin multi

Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21-q25

Congential dyserythropoietic anemia, type III (CDA III) is a rare autosomal dominant disorder characterized by macrocytic anemia, bone marrow erythroid hyperplasia and giant multlnucleate erythroblasts. We have genetically characterized a large Swedish family in which the concurrence of CDA III and myeloma or benign monoclonal gammopathy is significantly higher than expected and have found that th

Meta-analysis of four Swedish case-control studies on exposure to pesticides as risk-factor for soft-tissue sarcoma including the relation to tumour localization and histopathological type

In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies we studied such exposure including the relation to tumour localization and histopa

Adipose tissue concentrations of dioxins and dibenzofurans in patients with malignant lymphoproliferative diseases and in patients without a malignant disease

Concentrations of dioxins (PCDD) and dibenzofurans (PCDF) were analysed in adipose tissue from seven patients with malignant lymphoproliferative diseases and 12 surgical patients without a malignant disease. All cases in the first group had reported potential exposure to PCDD and PCDF. Of the analysed congeners significantly higher concentrations of 1, 2, 3, 7, 8-pentachlorodioxin, 1, 2, 3, 6, 7,

Spin-polarized electronic transport in a spin-valve based on a quantum dot

Electronic transport through a single-level quantum dot coupled to two ferromagnetic leads is studied in the sequential tunneling regime. Transport characteristics are calculated for arbitrary angle between magnetic moments of the electrodes. It is found that the diode feature in the transport characteristics is significantly suppressed for canted magnetic configurations. It is also shown that a s

Adipose tissue concentrations of dioxins and dibenzofurans in potentially exposed patients with malignant lymphoma or sarcoma

Epidemiological studies have suggested an association between exposure to phenoxyacetic acids, chlorophenols or their contaminating dioxins (PCDDs) and dibenzofurans (PCDFs) and soft-tissue sarcoma and malignant lymphoma. In this study adipose tissue concentrations of PCDDs and PCDFs were measured in nine patients with sarcoma or malignant lymphoma who had been exposed to phenoxyacetic acids or ch

A non-random deletion in the p53 gene in oral squamous cell carcinoma

In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at se

EVAR of AAA: Long term outcomes, disease progression and risk stratification

BackgroundEndovasvular aortic repair (EVAR) is the most commonly utilised technique for the treatment of abdominal aorticaneurysms (AAA) in tertiary referral centers. Detailed long-term outcomes of this technique are relatively scarce,especially for patients presenting symptomatically with AAA. Intra-operatively, proximal type Ia endoleak, involvingblood circulating into the AAA – due to poor prox

Language and landscape : geographical ontology in cross-linguistic perspective

This special issue is the outcome of collaborative work on the relationship between language and landscape, carried out in the Language and Cognition Group at the Max Planck Institute for Psycholinguistics. The contributions explore the linguistic categories of landscape terms and place names in nine genetically, typologically and geographically diverse languages, drawing on data from first-hand f

Oxygen therapy in patients with ST elevation myocardial infarction based on the culprit vessel: results from the randomized controlled SOCCER trial

Background: Oxygen (O2) treatment has been a cornerstone in the treatment of patients with myocardial infarction. Recent studies, however, state that supplemental O2 therapy may have no effect or harmful effects in these patients. The aim of this study was thus to evaluate the effect of O2 therapy in patients with ST Elevation Myocardial Infarction (STEMI) based on the culprit vessel; Left Anterio