The phase behavior of lactoferrin has been studied as a function of concentration at a pH and ionic strength where lactoferrin is known to interact effectively via a patch-patch attraction. In contrast to isotropic attractive potentials, the directional attraction gives rise to a different phase or solution behavior. At low concentrations, the protein dimerizes. As the concentration is increased,

Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Impr

Wikipedia has become a reference knowledge source for scores of NLP applications. One of its invaluable features lies in its multilingual nature, where articles on a same entity or concept can have from one to more than 200 different versions. The interlinking of language versions in Wikipedia has undergone a major renewal with the advent of Wikidata, a unified scheme to identify entities and their

Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack

The most efficient way of building up energy in an oscillating system is to do it in phase with a resonant frequency of the system. If the resonant frequency changes for any reason this is difficult to obtain with a static frequency generator. It is of course possible to sweep over a frequency interval to find the maximum repeatedly, but a frequency sweep takes time and it is performed at discrete

We present the development of a specialized concrete for neutron shielding at neutron research facilities, based on the addition of hydrogen atoms in the form of polyethylene and also B4C for enhancing the neutron capture properties of the concrete. We show information on the mechanical properties of the concrete and the neutronics, in particular its relevance to modern spallation neutron sources,

This article presents further biographical information about a little-known composer of mandolin and guitar pieces, the Italian-British musician and music teacher Angelo (Angy) Palumbo (1883–1960).

Optical genome mapping in nanochannels is a powerful genetic analysis method, complementary to deoxyribonucleic acid (DNA) sequencing. The method is based on detecting a pattern of fluorescent labels attached along individual DNA molecules. When such molecules are extended in nanochannels, the labels create a fluorescent genetic barcode that is used for mapping the DNA molecule to its genomic locu

ABSTRACT: In the light of the observed and projected regional warming trend in northern Europe, new recommendations are needed for climate-proofing the selection of forest trees seedlings and growth estimates. Drawing on recently developed climate data sets, both observations of the recent past, and scenarios for the future we present and analyse a set of climate indices tailored to be used for op

Public clouds such as Amazon Web Services (AWS) and Microsoft’s Azure provide excellent capabilities for scalable Web applications and Hadoop-based processing. Recent ad- ditions to public clouds to support connected devices and IoT have the potential to similarly disrupt emerging home- grown and/or proprietary approaches. While early public cloud IoT success stories have focused on smaller-scale

Background: Determination of the relaxation time constants T1 and T2 with quantitative magnetic resonance imaging is increasingly used for both research and clinical practice. Recently, groups have been formed within the Society of Cardiovascular Magnetic Resonance to address issues with relaxometry. However, so far they have avoided specific recommendations on methodology due to lack of consensus

Malaria parasites can have strong effects on the population dynamics and evolution of migratory bird species. In many species, parasite transmission occurs on the wintering grounds, but studies to determine the consequences of infection have taken place during the breeding season, when malaria parasites circulate at chronic levels. We examined the predictors of malarial infections for great reed w

Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. Methods and Results: Sixty female patients with arm lymphedema were followed for a 1-year period after surgery. The 36-item short-form health s

Objectives To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease. Design Prospective cohort study. Setting Orthopaedic Department in Sweden. Participants Patients with palpable Dupuytren's cord and active extension deficit (AED) ≥30° in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joint. A surgeon injected 0.80 m

This paper combines the Metropolis-Hastings Improved Particle Smoother (MHIPS) with marginalized models. It demonstrates the effectiveness of the combination by looking at two examples; a degenerate model of a double integrator and a fifth order mixed linear/nonlinear Gaussian (MLNLG) model. For the MLNLG model two different methods are compared with the non-marginalized case; the first marginaliz

BACKGROUND AND PURPOSE—: Compared with ischemic stroke (IS), the association of atrial fibrillation (AF) with transient ischemic attack (TIA) is less well established. We aimed to assess the proportion of AF in patients with TIA, and these patients’ characteristics and secondary preventive treatment in comparison to patients with IS. METHODS—: Hospital-based data on TIA and IS events, registered f

Mint/X11 is one of the four neuronal trafficking adaptors that interact with amyloid precursor protein (APP) and are linked with its cleavage to generate β-amyloid peptide, a key player in the pathology of Alzheimer's disease. How APP switches between adaptors at different stages of the secretory pathway is poorly understood. Here, we show that tyrosine phosphorylation of Mint1 regulates the desti