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Capacitance measurements were applied to mouse pancreatic beta-cells to elucidate the cellular mechanisms underlying biphasic insulin secretion. We report here that only <50 of the beta-cell's >10,000 granules are immediately available for release. The releasable granules tightly associate with the voltage-gated alpha(1C) Ca(2+) channels, and it is proposed that the release of these granules accou

Transplantation of embryonic nigral tissue ameliorates functional deficiencies in Parkinson disease. The main practical constraints of neural grafting are the shortage of human donor tissue and the poor survival of dopaminergic neurons grafted into patients, which is estimated at 5-10% (refs. 3,4). The required amount of human tissue could be considerably reduced if the neuronal survival was augme

Ripley's K-function was used to investigate the changes in spatial pattern among trees in a semi-natural mixed deciduous forest in Denmark over 50 years, from 1948 to 2001. Trees larger than 10 cm diameter in breast height (dbh) were mapped at 10-year intervals in 16 blocks within two former compartments. At the start of the observation, trees were found to be regularly distributed at distances le

The influence of footwear insulation on foot skin temperature in the cold at low activity was investigated. Simultaneously, the thermal and pain sensations, and the influence of steel toe cap were studied. Eight subjects were exposed for 85 minutes to three environmental temperatures (+3; -12 and -25 °C) wearing 5 different boots. Insulation of footwear was determined with a thermal foot model. Th

Homogeneous Charge Compression Ignition (HCCI) holds great promises for good fuel economy and low emissions of NOdx and soot. The concept of HCCI is premixed combustion of a highly diluted mixture. The dilution limits the combustion temperature and thus prevents extensive NOdx production. Load is controlled by altering the quality of the charge, rather than the quantity. No throttling together wit

In wireless communications, stationary terminal scenarios are becoming increasingly important as bitrates goes up. Consequently, the need to improve the knowledge about the channel behavior and to develop realistic channel models for these scenarios is also increasing. The present work comprises both measurements and modeling of the radio channel when the terminal is stationary. The measurements w

Five to 15% of patients with primary sclerosing cholangitis (PSC) develop cholangiocarcinoma (CC) with a median survival of 5 to 7 months, an outcome not significantly improved by liver transplantation. However, if CC is found incidentally during the procedure or in the explanted liver, 5-year survival rates of 35% are reported. A noninvasive method to detect CC small enough to allow for intended

Popular Abstract in Swedish Kaféet är en mötesplats. Alla möten vilar på gränser - på gränser mellan de som möts, som umgänget frambringar. ”Kafékultur, kommunikation och gränser” är en studie av det sociala livet på kaféer, som utvecklar den socialpsykologiska innebörden av gränsen. Den kan ses som ett bidrag till förståelsen av vår tids informella och elementära sociala liv – intressant inte minThe café is a social meeting place. An as yet un-moulded aspect of social life is boundaries – how meetings rest on boundaries between participants that their intercourse brings forth. The aim of this dissertation is to study the café as a sociological and social–psychological phenomenon and at the same time contribute to forming the social–psychological aspect of boundaries. The study also contri

RATIONALE AND OBJECTIVES: This study was performed to document the perceived decrease in fatty involution at screening mammography during the past decade and evaluate the influence of hormone replacement therapy (HRT). MATERIALS AND METHODS: In December 1996, the mammograms of 261 consecutive screening patients with a comparison study obtained 5 years earlier were evaluated, and their breasts were

Transient absorption anisotropy of a polythiophene polymer in a thin film was studied on a femtosecond time scale. The anisotropy has a non-exponential decay on the sub-picosecond time scale, with a fastest component characterized by an ∼40 fs time constant. To simulate the anisotropy decay an incoherent energy migration model has been used. Comparison between the simulated and experimental kineti

Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex aetiology and causes relevant morbidity and mortality due to different mechanisms, including but not limited to stroke, heart failure, and tachy- or bradyarrhythmia. Current therapeutic options (rate control, rhythm control, antithrombotic therapy, 'upstream therapy') only prevent a part of this burden of disease. Several n