Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edemato

Saving time to intervention is crucial in patients with symptomatic carotid artery stenosis (SCAS). We introduced a fast-track protocol (FTP). Time frames from the onset of symptoms to intervention before and after the introduction of an FTP were analyzed. SCAS patients (403 patients/405 procedures) were evaluated according to whether surgery was performed before (group 1) or after (group 2) the i

Abstract in UndeterminedUsing longitudinal data this work analyses historical fertility between 1834 and 1914 in an Alpine village situated in north-east Italy, characterised by scarce resources and by an economy which passed from being traditional and based on closed subsistence to becoming open and integrated. During the initial period studied, this territory can be described as a natural fertil

Wnt5a is a non-canonical Wnt protein that is expressed at elevated levels in inflammatory conditions. Its role in inflammation remains unclear, although it is known that Wnt5a is expressed at a higher level in monocyte-derived myeloid dendritic cells (Mo-mDCs) than in monocytes and macrophages. The function of Wnt5a in dendritic cells (DCs) remains relatively unexplored. Here, we found that under

Molecular simulations of strongly coupled dipolar systems of varying size have been carried out, using particles confined inside a dielectric cavity and an image charge approach to treat the dielectric response from the surroundings. A simple method using penalty functions was employed to create an isotropic and homogeneous distribution of particles inside the cavity. The dielectric response of th

The pathophysiology of sepsis-associated encephalopathy (SAE) is complex and remains incompletely elucidated. Dysregulated reactive oxygen species (ROS) production and mitochondrial-mediated necrotic-apoptotic pathway have been proposed as part of the pathogenesis. The present study aimed at analyzing the preventive effect of the free radical scavenger edaravone on sepsis-induced brain alterations

This study criticizes approaches equating opposition electoral victories with democratization in competitive authoritarian regimes. Not only are these approaches theoretically problematic, but there are also important empirical reasons to distinguish between electoral turnovers and democratization. The study goes on to explain why some African turnovers have been successful in bringing about democ

Three morphologically very similar species of Asecodes Förster (Hymenoptera: Eulophidae) are reviewed. Asecodes parviclava (Thomson) is removed from synonymy under A. lucens stat. rev., and differentiated from A. lucens (Nees) and A. lineophagum sp. n. All three species develop as gregarious endoparasitoids in larvae of Galerucella spp. (Coleoptera: Chrysomelidae), but each species has its own uni

Many biological wastewater treatment processes are based on bacterial biofilms, i.e. layered aggregates of microbial populations deposited on surfaces. Detachment and (re-)attachment leads to an exchange of biomass between the biofilm and the surrounding aqueous phase. Traditionally, mathematical models of biofilm processes do not take the contribution of the suspended, non-attached bacteria into

Presently there is an abundance of sites, across media, promoting acts of communal reading (televised book clubs, web rings, publishers’ book discussion questions, etc.). This article forms a case study of what usages of reading and concurrently what reading subjects are framed in the Swedish televised book club, Malous bokklubb (Malou’s Book Club), modelled on Oprah’s Book Club in the USA and Ric

Imaging techniques that provide detailed insights into structural tissue changes after stroke can vitalize development of treatment strategies and diagnosis of disease. Diffusion-weighted MRI has been playing an important role in this regard. Diffusion kurtosis imaging (DKI), a recent addition to this repertoire, has opened up further possibilities in extending our knowledge about structural tissu

The hydrogen absorption mechanism of the 2NaH + MgB2 system has been investigated in detail. Depending on the applied hydrogen pressure, different intermediate phases are observed. In the case of absorption measurements performed under 50 bar of hydrogen pressure, NaBH4 is found not to be formed directly. Instead, first an unknown phase is formed, followed upon further heating by the formation of

To estimate the impact of urbanization on wild animals, it is important to know how different species, populations and/or individuals deal with and respond to environmental stress. Are more urbanized species adapted to their environment, or do individuals acclimatize over the course of their life? Alternatively, do they simply cope at the expense of other functions? These are three key processes t

OBJECTIVES: The aim was to gather information regarding what students consider important for their motivation to attain knowledge, in order to shape courses that foster this motivation. METHOD: A qualitative design comprising focus groups including 31 nursing and medical students for interviews, semi-structured questions, and content analysis was utilized. RESULT: The students thought it was impor

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)

This study examined how differences in visuo-perceptual patterns are related to psychopathology. Fifty-six patients (37 women, 19 men; M age = 43.8 yr., SD = 13.4) with a main diagnosis of unipolar depression and 42 patients (22 women, 20 men; M age = 42.0 yr., SD = 11.1) with a main diagnosis of somatoform disorder were compared. The duration and trend of a visual motion aftereffect were measured

To distinguish between natural and anthropogenic forcing, the supposedly ongoing global warming needs to be put in a longer, geological perspective. When the last ca. 20 000 yr of climate development is reviewed, including the climatically dramatic period when the Last Ice Age ended, the Last Termination, it appears that the last centuries of globally rising temperatures should be regarded as an a