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Construction of an ultrasound phantom with micrometer-sized wall-less vessels

The development of new ultrasound imaging technologies that aim to resolve objects smaller than the conventional ultrasounds diffraction limit calls for new types of phantoms to evaluate these technologies. When it comes to vascular flow phantoms, this becomes challenging due to the difficulty of manufacturing phantoms with vessels smaller than 1 mm in diameter. Here we describe a novel manufactur

A Process for Improved Decision-Support based on Probabilistic Methods for Risk Analysis and Building Energy Performance

This paper presents a preliminary method developed for improved decision-support based on probabilistic methods for risk assessment using building performance simulations. The aim of the method is to support the decision-maker in all stages of the building process when deciding on the design of a building by including uncertainties and quantifying; the probability of fulfilling objectives; energy

Possibilities with Probabilistic Methods for Dynamic Building Energy Simulations using Stochastic Input Data : – Initial Analysis

As observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations basedon traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertainAs observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations based on traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertai

Future application of probabilistic methods for building performance simulations

Many countries strive for continued reductions in energy demand from new buildings as a way of mitigating the impact of climate change. Consequently, the importance of accurate and efficient building performance simulations (BPS) increases to improve the prediction in energy demand during the design-process for buildings. As observed in earlier studies, there is currently a performance gap between

Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with pot

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cance

Revolving permanent magnet causes rotating particle motion that makes new detection schemes possible in magnetomotive ultrasound

Magnetomotive ultrasound, MMUS, can reveal the presence of a magnetic contrast agent by applying an external magnetic field. If the interaction between the agent and the field is strong enough, a movement that can be detected by ultrasound is induced in the surrounding tissue, thereby inferring the contrast agent distribution. Electromagnets have been used to generate the necessary magnetic field,

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We te

Quality Improvement Initiatives in Fragility Fracture Care and Prevention

Purpose of Review: This review sought to describe quality improvement initiatives in fragility fracture care and prevention. Recent Findings: A major care gap persists throughout the world in the secondary prevention of fragility fractures. Systematic reviews have confirmed that the Fracture Liaison Service (FLS) model of care is associated with significant improvements in rates of bone mineral de

Day Fines in Sweden

As in other areas of social engineering, Sweden is considered as world-leading in creating systems that address social inequality. One of the cases in point is the Swedish day-fine system which has been considered as pioneering by systematically considering both the wealth of the offender and the seriousness of the offence when imposing the penalty. This chapter analyses in detail the Swedish day-

Outsourcing Public Services: Contractibility, Cost, and Quality

We review the literature on public sector outsourcing to explore if the theoretical predictions from the incomplete contracts literature hold up to recent empirical evidence. Guided by theory, we arrange services according to the type and magnitude of their contractibility problems. The empirical studies point at rather favourable outsourcing outcomes, in terms of costs and quality, for services w

Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality : a prospective study

AIMS/HYPOTHESIS: Evidence that glucose-dependent insulinotropic peptide (GIP) and/or the GIP receptor (GIPR) are involved in cardiovascular biology is emerging. We hypothesised that GIP has untoward effects on cardiovascular biology, in contrast to glucagon-like peptide 1 (GLP-1), and therefore investigated the effects of GIP and GLP-1 concentrations on cardiovascular disease (CVD) and mortality r

Substantial intrinsic variability in chemoradiosensitivity of newly established anaplastic thyroid cancer cell-lines

Background: Well characterized human cell lines are needed for preclinical treatment studies of anaplastic thyroid cancer (ATC).Aims/Objectives: The aim was to establish, verify and characterize a panel of ATC cell lines.Material and methods: Cell lines were established from ATC fine-needle aspiration biopsies and characterized genetically and functionally regarding treatment sensitivities.Results