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Circulating Markers of Neutrophil Extracellular Traps (NETs) in Patients With Ovarian Tumors
BACKGROUND/AIM: Inflammation is a hallmark of cancer, and the role of neutrophils and neutrophil extracellular traps (NETs) in cancer and cancer-associated thrombosis has attracted a lot of interest. The NET-specific marker H3Cit has been found to be elevated in the plasma of patients with malignancies, suggesting NETs markers as novel cancer biomarkers. This study aimed to determine the levels of
Lessons Learned from a Study on Distractions in Virtual Learning Environments : Reliability, Ecological Validity, and an Elusive Social Component
Virtual Reality has long been proposed to combine the reliability of controlled laboratory settings with the ecological validity of real life. While the technological development steadily pushes towards even more realistic renderings of the real world— the elusiveness of social and emotional elements gradually becomes more evident. This is not the least true for behavioral studies in rich sociocul
On the fractional susceptibility function of piecewise expanding maps
We associate to a perturbation (ft) of a (stably mixing) piecewise expanding unimodal map f0 a two-variable fractional susceptibility function Ψφ(η, z), depending also on a bounded observable φ. For fixed η ∈ (0, 1), we show that the function Ψφ(η, z) is holomorphic in a disc Dη ⊂ C centered at zero of radius > 1, and that Ψφ(η, 1) is the Marchaud fractional derivative of order η of the function t
Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins
The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. Although a number of important interactions by proteins such as selectins, galectins, and sialic acid-binding immunoglobulin-like lectins are thought to mainly rely on su
Indicator frameworks for fostering open knowledge practices in science and scholarship
The aim of this report is to contribute to the European vision for Open Science (European Commission 2016) by providing the frameworks for understanding and applying science and technology indicators, defined broadly, to enable the transition from the current scientific and scholarly system towards a more open and inclusive configuration of knowledge practices and infrastructures. Indicators for O
Glucose as a marker of fluid absorption in bipolar transurethral surgery.
BACKGROUND: Historically, a reduced serum sodium concentration has been used to diagnose absorption of electrolyte-free irrigating fluid during transurethral resection of the prostate (TURP). In bipolar TURP, the irrigating solution contains electrolytes, thus invalidating the serum sodium method. In this study, we investigated whether glucose can be used to diagnose the absorption of irrigating f
Facing a pandemic: African armies and the fight against COVID-19
The goal of this report is to empirically study the domestic deployment of militaries to manage the pandemic on the African continent. In this perspective, the COVID-19 crisis is a case study of continuity and change: both within civil-military relations more broadly and within the armed forces in particular. The report focuses on four cases: Sierra Leone by Maggie Dwyer and Osman Gbla; Burkina Fa
A framework for participatory work environment interventions in home care – success factors and some challenges
BackgroundHome care is beset with work environment issues and high staff turnover, while research concerned with interventions to improve the work environment is sparse. Few of the existing interventions apply a participative approach, despite this being associated with more positive outcomes and sustainable change. This paper presents a framework, rooted in action research and action learning, fo
Are biventricular and biatrial function truly preserved after arterial switch operation?
Cardiovascular Magnetic Resonance in Right Heart and Pulmonary Circulation Disorders
Right heart and pulmonary circulation disorders are generally caused by right ventricle (RV) pressure overload, volume overload, and cardiomyopathy, and they are associated with distinct clinical courses and therapeutic approaches, although they often may coexist. Cardiac magnetic resonance (CMR) provides a noninvasive accurate and reproducible multiplanar anatomic and functional assessment, tissu
My Fault or Default—Household Behaviors Living in a Climate-Smart Building
Decreasing climate impact of households is a concern for many actors. One way to address this challenge is to focus on household behaviors related to energy use and consumption. Another is to construct climate-smart houses that encourage households to utilize smart functions that reduce emissions. This article examines the link between these two strategies and investigates how living in a climate-
Gender and public participation : A study of the swedish public debate on the nord stream gas pipeline from a gender perspective
This article focuses on public participation in Sweden during the planning of the Nord Stream gas pipeline. The pipeline runs from Russia to Germany, and passes close to the Swedish island of Gotland. Results from a survey study conducted among 990 Swedish citizens, where 200 respondents are residents on the island of Gotland, reveal that there are differences between men and women in how risks wi
Fight, flight or freeze : Assumed reactions of the public during a crisis
This article reports on how professionals at municipal level responsible for crisis communication (N=152) in Sweden judge the probability of 10 different responses occurring among the public, among people within their own emergency organization and themselves in case of a crisis. The direct physical effects of the crisis were kept identical throughout the study, but the cause of the crisis varied
Underlying concerns in land-use conflicts - The role of place-identity in risk perception
In the last few years, debates over proposed usage of land for high-risk ventures have caused some debate, both in the affected communities as well as among policy makers. It has been recognized by industry and government agencies that the opinion and concerns of the local population has to be considered in order to mediate or reduce conflicts. Usually these concerns tend to focus on issues of hea
Cause and consequences of crises : How perception can influence communication
This article focuses on how different events that cause a crisis are perceived by communication officers. The aim of this paper is to investigate how the attribution of whatever has caused a crisis affects how the crisis is perceived and how this in turn affects communication efforts. Previous research indicates that people will respond differently to risks depending on the cause of the risk, even
Is there a role for immunomodulatory drugs in the treatment of mantle cell lymphoma?
Although survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MCAlthough survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MC
Survival in mantle cell lymphoma after frontline treatment with R-bendamustine, R-CHOP and the Nordic MCL2 regimen - a real world study on patients diagnosed in Sweden 2007-2017
Från en offentlighet till en annan : Medialiseringen av Anna Månsdotters avrättning 1890
L68Q cystatin C. Expression, cellular transport and turnover of the cystatin C variant forming amyloid in patients with Hereditary Cystatin C Amyloid Angiopathy (HCCAA)
Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 to Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel