Retinitis pigmentosa (RP) is a heterogeneous group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness. Many human cases are caused by mutations in the rhodopsin gene. An important question regarding RP pathology is whether different genetic defects trigger the same or different cell death mechanisms. To answer this question, we analysed photoreceptor degeneratio

The theory of symmetric operators has several deep applications to the function theory of certain reproducing kernel Hilbert spaces of analytic functions, as well as to the study of ordinary differential operators in mathematical physics. Examples of simple symmetric operators include multiplication operators on various spaces of analytic functions (model subspaces of Hardy spaces, de Branges-Rovn

In northern peatlands the thawing of permafrost increasing the active layer depth and changing the hydrology may lead to feedbacks in the climate system through changes in the biogeochemistry of carbon. We are examining this association on the Stordalen peatland complex in subarctic Sweden by analyzing a DEM derived from LiDAR-data and the calculated TWI. The DEM, with a spatial resolution of 1 m,

Accessibility in public outdoor environments for those with reduced functional capacity has been gaining interest on both the international and national levels. The study investigates how accessibility issues are currently treated in Swedish municipalities in order to examine how older peoples’ accessibility needs are met in daily practice. A postal questionnaire was sent to all municipalities in

Abstract is not available

Background: Innate defence mechanisms of the airways are impaired in chronic obstructive pulmonary disease (COPD), predisposing patients to lower respiratory tract infections, but less is known about the association with other infections. In this population-based cohort study, we investigated the associations between COPD and invasive bacterial disease by comparing incidence rates of bacteraemia i

Pollination by bees is important for food production. Recent concerns about the declines of both domestic and wild bees, calls for measures to promote wild pollinator populations in farmland. However, to be able to efficiently promote and prioritize between measures that benefit pollinators, such as modified land use, agri-environment schemes, or specific conservation measures, it is important to

The book starts in the archaeological excavations at Hovdala castle in northern Skåne. From the results emerging fråm the excavation a journey in time and space leads to a migration period bigfarm at the shore of the Finja lake.. This leads to an analysis of the colonisation and developement of the area up to the 17:th century when the castle was burned by the swedish king Gustavus II.

Ostreopsis ovata is a benthic dinoflagellate that produces palytoxin and its analogues. Since the end of the 1990s, toxic blooms of O. ovata have been recorded in many tropical and temperate marine waters. These blooms often kill benthic invertebrates and cause health problems for humans. We hypothesize that increases in seawater temperature might induce these blooms. A strain of O. ovata isolated

The idea of a usable methodology, one which will both retain the idea of 'a subject' at the heart of research and also recognize that in historical research the researcher necessarily has to work with textual remains, is discussed. Piecing this together is explored in relation to researching correspondences and other archival materials relating to two women who were fin de siecle prostitutes and a

Glioblastoma multiforme is the most common and aggressive malignant brain tumor in humans, and the prognosis is very poor despite conventional therapy. Immunotherapy represents a novel treatment approach, but the effect is often weakened by release of immune-suppressive molecules such as prostaglandins. In the current study, we investigated the effect of immunotherapy with irradiated interferon-γ

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels a

Arterial stiffness reflects the ageing processes in the vascular system, and studies have shown an association between reduced cognitive function and cerebral small vessel disease. Small vessel disease can be visualized as white matter hyperintensities (WMH) and lacunar infarcts but also as cerebral microbleeds on brain magnetic resonance imaging (MRI). We aimed to investigate if arterial stiffnes

Popular Abstract in Swedish Interdisciplinära smärtrehabiliteringsprogram har visat bättre resultat än mindre intensiva åtgärder. Det saknas dock kunskap inom flera olika områden. Denna avhandling har bland annat fokuserat vilka aktivitetsproblem som personer som genomgått ett sådant program upplever viktigast att förbättra. Alla deltagarna i programmet hade långvarig muskuloskeltal smärta med komMultidisciplinary pain rehabilitation programmes are found decreasing pain and improve back-to-work rates. There is, however, a lack of knowledge in several respects. The overall aim of this thesis was to study outcomes in terms of occupational performance, satisfaction with performance, psychosocial functioning, disability, and coping profiles at a one-year follow-up after a musculoskeletal pain

During 2007 and 2008 the speed limits 40 och 60 km/h have been tried out in twelve Swedish cities, out of which six have participated in a evaluation in this project, financed by the Swedish National Road Administration. The evaluation has focused on effects from the changes in speed limits on actual speeds, safety, environment and travel times, as well as the attitudes towards the new speed limit