Search results

Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglut

BACKGROUND: Orthopaedic surgeons aim for mechanical alignment when performing total knee arthroplasty (TKA) as malalignment is associated with loosening. Loosening may be predicted by migration as measured with radiostereometric analysis (RSA), but previous RSA studies on postoperative alignment have shown contradictory results and have been limited to cemented implants and small numbers of patien

Telemedicine is the use of telecommunication and information technologies to support the delivery of healthcare at a distance, guaranteeing patients healthcare by facilitating access where barriers exist; the COVID-19 pandemic has attracted worldwide interest in this field. The purpose of this paper is to highlight the main pros and cons of telemedicine, which serve as the basis of the WONCA Europ

The discovery of TRPV1 as a receptor for capsaicin, the pungent ingredient in chili pepper, and noxious heat has triggered immense research on the role of TRP channels as polymodal receptors in sensory neuronal signaling. The rich abundance of TRPV1 in nociceptive primary afferents and its involvement in inflammatory and neuropathic pain encouraged the development of analgesics acting on TRPV1. Ho

In order to investigate the characteristics of gas-liquid two-phase flows in horizontal mini circular tubes with inner diameters of 3.14 and 6.68 mm, a prism is adopted to improve the light path in the visualization experimental setup. The front and top views of air-water two-phase flow patterns in two tubes are captured synchronously based on the improved method. Three-dimensional gas-liquid inte

Increasing iron (Fe) concentrations are found in lakes on a wide geographical scale but exact causes are still debated. The observed trends might result from increased Fe loading from the terrestrial catchment, but also from changes in how Fe distributes between the water column and the sediments. To get a better understanding of the causes we investigated whether there has been any change in the

Central venous catheterisation is one of the most common invasive procedures performed on patients in secondary care. Unfortunately the catheterisation procedure is associated with mechanical complications that both can be life-threatening and may force postponement of life-saving treatments such as surgery and chemotherapy. The use of real-time ultrasound guidance increases success rates and redu

INTRODUCTION: Informal carers in paid employment-working carers (WKCs)-have complex support needs. However, little is known about WKCs' pattern of informal care provision, the support they receive, the impact providing care has on their employment, and how these vary between male and female WKCs. This study describes the pattern of informal care provision and received support among Swedish WKCs.RE

The copper IUD is a widely used contraceptive, recommended to many women who want a long-acting contraceptive method and sometimes seen as an alternative for those who want to avoid side effects associated with hormonal alternatives. However, while many report being satisfied with their copper IUD, a growing number of women speak about a range of mental and physical symptoms believed to be caused

In this study, pool boiling heat transfer of de-ionized water was experimentally studied on a scored copper surface at a heat-flux range of 0 - 60 W/cm2. Bubble dynamics in an isolated bubble region were carefully investigated, including bubble departure diameters, bubble departure frequencies, and active nucleation site densities. The bubble dynamics were compared with available models, indicatin

In today’s society, learning is a lifelong pursuit for all professionals who want to become and stay successful in their profession. However, in contrast to formal academic training, workplace learning is often informal and relatively unnoticed by competence developers in both academia and industry. This paper therefore sets out to identify and describe how such learning takes place in practice. M

Interferon-g-inducible protein 10 (IP-10) has been suggested as a marker for targeted viral load (VL) monitoring during antiretroviral treatment (ART). We aimed to determine the kinetics of IP-10 during the initial year of ART, with particular regard to the impact of tuberculosis (TB) co-infection on IP-10 secretion. Longitudinal plasma IP-10 levels were quantified in 112 treatment-naive HIV-posit

BACKGROUND: The St Gallen 2019 guidelines for primary therapy of early breast cancer recommend omission of completion axillary lymph node dissection (cALND), regardless of histological type, in patients with one or two sentinel lymph node (SLN) metastases. Concurrently, adjuvant chemotherapy is endorsed for luminal A-like disease with four or more axillary lymph node (ALN) metastases. The aim of t

Abstract in GermanDas Thema dieses Beitrags ist die Übersetzung deutscher Partizipialkonstruktionen ins Schwedische – ein Thema, dem die bisherige Forschung kaum Aufmerksamkeit geschenkt hat. Die Studie ist sowohl quantitativer als auch qualitativer Natur. Als Korpus dienen deutsche Sachprosatexte und ihre schwedischen Übersetzungen, von denen anzunehmen ist, dass sie im Einklang mit den entsprech

Vildsvin är ett omdiskuterat djurslag i Sverige. Många ser dem som ett uppskattat inslag i naturen, dels som jaktbyte och dels för att de bidrar till naturupplevelser, skogstillväxt och biologisk mångfald. Samtidigt orsakar de skador på jord- och skogsbruk, villatomter och grönområden samt trafikolyckor. Dessa kostnader drabbar ofta andra än dem som anser sig dra nytta av vildsvinens existens. Und

Sverige har ambitiösa mål för att öka den ekologiskt odlade jordbruksmarken. Samtidigt är det inte självklart att ekologisk odling är bättre för miljön. Här sammanställer vi kunskap om skillnader mellan ekologisk och konventionell odling i Sverige. De miljöfaktorer vi tittar på är biologisk mångfald, näringsläckage och utsläpp av växthusgaser. Sammanställningen tyder på att när miljöpåverkan mäts

The past years have seen an increasing debate on cooperation and its unique human character. Philosophers and psychologists have proposed that cooperative activities are characterized by shared goals to which participants are committed through the ability to understand each other’s intentions. Despite its popularity, some serious issues arise with this approach to cooperation. First, one may chall

Play has proved to have a central role in children's development, most notably in rule learning (Piaget, 1965; Sutton-Smith, 1979) and negotiation of roles and goals (Garvey, 1974; Bruner et al., 1976). Yet very little research has been done on early play. The present study focuses on early social games, i.e., vocal-kinetic play routines that mothers use to interact with infants from very early on