On the pharmacodynamics, pharmacokinetics and metabolism of sulphonylurea and its metabolites - with special reference to glibenclamide
The pharmacodynamics (PD), pharmacokinetics (PK) and metabolism of the sulphonylurea(SU) and its metabolites (M1 and M2) , and of another SU, glipizide (Gz) were studied in diabetes patients and healthy volunteers. In one study Caucasians and Chinese were compared. Sensitive and selective methods for determination of drug levels and concentrations of insulin and proinsulin were used. The terminal