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Substrate and product dependence of force and shortening in fast and slow smooth muscle

To explore the molecular mechanisms responsible for the variation in smooth muscle contractile kinetics, the influence of MgATP, MgADP, and inorganic phosphate (P(i)) on force and shortening velocity in thiophosphorylated "fast" (taenia coli: maximal shortening velocity Vmax = 0.11 ML/s) and "slow" (aorta: Vmax = 0.015 ML/s) smooth muscle from the guinea pig were compared. P(i) inhibited active fo

Enhanced surface sensitivity in AES relative to XPS observed in free argon clusters

The surface-to-bulk intensity ratio in Auger electron spectra has been studied in comparison with core-level photoelectron spectra using free argon clusters of sizes ranging over two orders of magnitude. Enhanced surface sensitivity is observed in L2,3M2,3M2.3 Auger electron spectra compared to 2p photoelectron spectra where electrons of similar kinetic energies were recorded. This is discussed in

Follow-up after colorectal cancer surgery

Although most institutions offer some kind of follow-up to patients operated on for colorectal cancer, its value with respect to prolonged survival has been challenged. However, improved results of liver surgery and chemotherapy make it reasonable to assume that a follow-up programme leading to detection of more asymptomatic recurrences would result in improved survival. Liver metastases and extra

The kinetics of the reaction of hydrogen chloride with fresh and spent Ca-based desulfurization sorbents

The absorption of hydrogen chloride by spent desulfurization sorbents containing calcium carbonate, calcium oxide and calcium hydroxide was investigated. The experiments were carried out in a fixed-bed reactor in two temperature ranges: 423-523 K for slaked lime and 673-873 K for limestone and quicklime. The spent Ca-based sorbents can still react with hydrogen chloride, and after calcining and sl

The N=47 Shell-model Nucleus 90Tc

Lifetimes of high spin states in the nucleus Tc-90 have been measured via the fusion evaporation reactions Ni-58(Ar-36, 3pn)Tc-90 at 140 MeV and Ni-58(Cl-35, 2pn)Tc-90 at 120 MeV beam energy. The OSIRIS spectrometer as well as a new neutron-gamma-coincidence setup were used to measure lifetimes in the 10(-12) - 10(-9) s range by the recoil distance Doppler-shift method. By means of gamma-multiplic

Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts

Background/Aims: Endothelin-1 (ET-1) has been implicated in pathologic remodelling and tissue repair processes in the heart. We investigated the effects of ET-1 on growth and collagen synthesis responses in cardiac fibroblasts isolated from human hearts. We also studied the receptor subtype(s) mediating such responses and the factors regulating their expression. Methods: Fibroblasts were isolated

On the Causes of Famine - Drought, Desertification and Market Failure in the Sudan

Many natural scientists foster the idea of a degrading environment, caused by over-exploitation of the resources, being the cause of famine and poverty in Africa. In accordance with this, policies aimed at restoring the environment are formulated. This article analyses the main causes of famine, i.e. drought, desertification and the food market, with examples from the 1984-85 famine in the Sudan.

17 sunda hus : goda exempel, daghem och skolor

Denna skrift redovisar sjutton exempel på sunda hus - nio daghem och åtta skolor där brukarna upplever ett tillfredsställande inomhusklimat. Samtliga byggnader har nyligen uppförts eller byggts om. Skriften innehåller dokumentation av hur man gått till väga vid arbetet - målsättning, planeringsprocessen, byggnadstekniska fakta, energianvändning och städvanor samt utvärdering av enkäter och mätning

Model scale compartment fire tests with wall lining materials

Two series of tests with wall lining materials in an extensively equipped model scale room have been carried out. The dimensions of the room were 1.2 X 0.8 X 0.8 m³. In test series I the wall lining materials were mounted on three walls and in the ceiling. This test series comprised thirteen different materials. In test series I1 ten different materials were tested. They were mounted on the walls

Molecular mapping of the Goodpasture's epitope for glomerulonephritis

Goodpasture's syndrome is an autoimmune disease characterized by pulmonary hemorrhage, glomerulonephritis, and antiglomerular basement membrane (GBM) antibodies. We have studied a rat model with chimeric proteins (CPs) consisting of portions of the nephritogenic non-collagenous domain of alpha3 type IV collagen (alpha3(IV)NC1) and non-nephritogenic alpha1(IV)NC1. CPs with aminoterminal alpha3 that

Use of outcome instruments to compare workers' compensation and non-workers' compensation carpal tunnel syndrome

Validated outcome instruments were used to compare treatment outcomes of carpal tunnel syndrome (CTS) in workers' compensation and non-workers' compensation patients. A self-administered questionnaire consisting of the generic Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the disease-specific Carpal Tunnel Syndrome Instrument was mailed to 277 patients randomly selected from

No increase of plasma malondialdehyde after primary coronary angioplasty for acute myocardial infarction.

OBJECTIVE: Free radicals formed after coronary artery occlusion and reperfusion are assumed to produce myocardial stunning and possibly other forms of reperfusion injury as well. Malondialdehyde (MDA) is an end product in the lipid peroxidation chain reaction and is frequently used as a marker for free oxygen radical production. Increased levels of plasma MDA have been found following successful t