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On Batch recipe Structures Using High-Level Grafchart

Batch processes are very common and important in e.g. the chemical industries. The international standard ISA88.01 defines the terminology, the functionality and the models for batch control systems. The production specification of how to produce a batch, is called a recipe. This paper shows how high-Level Grafchart, a Grafcet and High-Level Petri net based programming language can be used to repr

Influence of blood prostate specific antigen levels at age 60 on benefits and harms of prostate cancer screening : Population based cohort study

Objective To determine the relative risks of prostate cancer incidence, metastasis, and mortality associated with screening by serum prostate specific antigen (PSA) levels at age 60. Design Population based cohort study. Setting General male population of Sweden taking part in a screening trial in Gothenburg or participating in a cardiovascular study, the Malmo Preventive Project. Participants The

Tourism as connectedness

Late modernity in developed nations is characterized by changing social and psychological conditions, including individualization, processes of competition and loneliness. Remaining socially connected is becoming increasingly important. In this situation, travel provides meaning through physical encounters, inclusion in traveller Gemeinschaft based on shared norms, beliefs and interests, and socia

Articulating influence : Toward a research agenda for interpreting the evaluation of soft power, public diplomacy and nation brands

While the terms soft power, public diplomacy (PD) and nation brands have cemented their place in academic discourse during the early 21st century, the evaluation of these activities has not been given anywhere near the same level of attention. When describing how campaigns are evaluated, scholars tend to make assumptions based on the goals or outputs of an initiative rather than on the basis of re

Reslizumab for Inadequately Controlled Asthma with Elevated Blood Eosinophil Levels : a Randomized Phase 3 Study

BACKGROUND: This phase 3 study further characterizes the efficacy and safety of reslizumab (a humanized anti-interleukin-5 monoclonal antibody) in patients aged 12-75 years with asthma inadequately controlled by at least a medium-dose inhaled corticosteroid, and blood eosinophils ≥400cells/μL.METHODS: Patients were randomized to receive reslizumab 0.3 or 3.0mg/kg or placebo once/every 4 weeks/16 w

A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort

PURPOSE: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovar

TuneR: A Framework for Tuning Software Engineering Tools with Hands-on Instructions in R

Numerous tools automating various aspects of software engineering have been developed, and many of the tools are highly configurable through parameters. Understanding the parameters of advanced tools often requires deep understanding of complex algorithms. Unfortunately, suboptimal parameter settings limit the performance of tools and hinder industrial adaptation, but still few studies address the

Model for individual prediction of diabetes up to 5 years after gestational diabetes mellitus

AIMS: To identify predictors of diabetes development up to 5 years after gestational diabetes mellitus (GDM) and to develop a prediction model for individual use.METHODS: Five years after GDM, a 75-g oral glucose tolerance test (OGTT) was performed in 362 women, excluding women already diagnosed with diabetes at 1- to 2-year follow-up or later (n = 45). All but 21 women had results from follow-up

High-pressure transitions of trigonal α-ZrMo2O8

High-pressure synchrotron x-ray powder-diffraction studies show that trigonal α-ZrMo2O8 transforms to a monoclinic symmetry phase (δ-ZrMo2O8) at 1.06-1.11 GPa. The space group was determined to C2/m. A further high-pressure transition from the monoclinic δ to a triclinic ε phase occur at 2.0-2.5 GPa (space group P1 or P1). Both transformations are reversible. The volume compressibilities are simil

Pressure-induced phase transitions in α-ZrMo2O8

We report high-pressure Raman, infrared (IR), and optical-absorption spectra of α-ZrMo2O8 (trigonal) up to 38 GPa at room temperature. The spectroscopic studies are consistent with diffraction results that show that α-ZrMo2O8 transforms into δ-ZrMo2O8 (monoclinic) at about 1 GPa and the δ phase converts to the ε phase (triclinic) at about 2.0 GPa. Optical-absorption measurements give an estimate o