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Five biomarkers from one cerebrospinal fluid sample to stage Alzheimer’s disease

Staging Alzheimer’s disease on the basis of the disease’s biological underpinnings might help with stratification and prognostication, both in the clinical setting and in clinical trials. We propose a staging model based on only five biomarkers, which are related to amyloid-β and tau pathologies in different ways and can be measured with a single sample of cerebrospinal fluid.

AGREE II Quality Assessment of National and International Clinical Practice Guidelines on Prostate Cancer Management by the OPTIMA Consortium

Background and objective: Clinical practice guidelines for prostate cancer (PCa) are a valuable resource for everyday clinical practice. The clinical practice guidelines and recommendations produced by various societies should demonstrate a considerable level of consistency in terms of quality, regardless of the society that developed these given the common evidence base. However, to date, no stud

CoopeRIS : A framework for the simulation of reconfigurable intelligent surfaces in cooperative driving environments

Future connected vehicles will require high-performance communication technologies for advanced cooperative driving applications such as maneuvering and cooperative perception. mmWave communications can meet the bandwidth requirements of such applications, but the typically harsh propagation conditions of vehicular environments hinder the broad adoption of mmWave devices on cars. Reconfigurable in

Ambiguity, arguments and visions : First-year teacher student voices on digital teaching during COVID-19

Lund University (Sweden) teacher education students' reflections constitute the foundation for this chapter. The students wrote about their situation, what they could learn from it and how they could bring these lessons into their future roles. The students' voices on digitalisation and isolation in their learning experiences illustrate the importance of belonging and motivation in education. The

Diagnostic value of repeated comprehensive investigation with CT urography and cystoscopy for recurrent macroscopic haematuria

Objectives: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria. Methods: All p

Accuracy versus precision in boosted top tagging with the ATLAS detector

The identification of top quark decays where the top quark has a large momentum transverse to the beam axis, known as top tagging, is a crucial component in many measurements of Standard Model processes and searches for beyond the Standard Model physics at the Large Hadron Collider. Machine learning techniques have improved the performance of top tagging algorithms, but the size of the systematic

Repeatability Assessment in Tunnel Fire Experiments

A medium-scale experimental setup located in Revinge, Sweden, is used to generate new repeated experimental datasets focussed on measuring a set of key variables, including time-temperature curves and temperature profiles. A total of 6 repeated fire tests were conducted and are here used to exemplify typical issues associated with repeatability, uncertainty and variability in tunnel fire experimen

Theoretical rigor of customer experience scales : a systematic review and a roadmap for researchers

Purpose: Prior research has proposed a number of scales measuring the customer experience (CX), which tend to conceptualize and operationalize CX differently, raising potential confusion among researchers (e.g. regarding which scale to use). Addressing this issue, this article conducts a systematic review to inventorize key CX scales and assess their theoretical rigor, with a focus on the identifi

Food aid professionals’ thoughts on the dignity of visitors while maintaining their own

The aim of this study was to reveal how professionals involved in food aid think about the dignity of visitors while maintaining their own. Ten food aid professionals participated in individual open semi-structured interviews. The theoretical concepts of dignity, discretion, self-presentation, and stigma were used in the analysis. In the professionals’ reasoning, four partly overlapping approaches

Gender in Monolingual and Bilingual First Language Acquisition : Comparing Italian and French

The present paper deals with the acquisition of gender in Italian and French by monolingual and bilingual children. In our study, which is based on the data of five children, we focus on the gender marking on articles, because gender is most frequently marked on these elements. We claim that the Italian gender system is easier to acquire than the French gender system. This is because the formal pr

Prevalens av Compassion Fatigue och Compassion Satisfaction hos Ambulanspersonal i Sverige: En enkätstudie med kvantitativ ansats

Bakgrund: Ambulanspersonal hanterar ofta känslomässigt utmanande och traumatiska situationer, vilket kan leda till compassion fatigue, en form av emotionell utmattning som påverkar deras empatiska förmåga och välbefinnande. Samtidigt finns compassion satisfaction, den positiva känsla som uppstår när ambulanspersonal upplever tillfredsställelse och mening i sitt arbete. Compassion satisfaction fung

Testing the effects of frequency on the rate of learning : Determiner use in early French, German and Italian

This paper examines whether the token frequency of bare nouns in child-directed input is related to the amount of determiner omission in child lan-guage by comparing input and child data in the languages French, Germanand Italian. It is shown that these languages differ in the extent to whichthey allow and require bare nouns. Although French exhibits the lowestnumber of bare nouns, French-learning

Assessing the impact of global carbon dioxide changes on atmospheric fluctuations in Iran through satellite data analysis

Atmospheric Carbon Dioxide (CO2), a significant greenhouse gas, drives climate change, influencing temperature, rainfall, and the hydrologic cycle. This alters precipitation patterns, intensifies storms, and changes drought frequency and timing of floods, impacting ecosystems, agri-culture, water resources, and societies globally. Understanding how global CO2 fluctuations impact regional atmospher

Effect of nanoparticle concentration and surfactants on nanofluid pool boiling

Silica nanofluids are prepared with a concentration varying from 0.001 vol.% to 0.003 vol.%, and pool boiling of the nanofluids is experimentally investigated. It is found that critical heat flux and heat transfer coefficient increase by a maximum of 62.66% and 45.88% compared with deionized water. The best boiling performance is achieved with the nanofluid of 0.002 vol.%. In addition, the paper f