Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the D

The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. In the fir

Secondary nucleation of monomers on the surface of an already existing aggregate that is formed from the same kind of monomers may lead to autocatalytic amplification of a self-assembly process. Such monomer-dependent secondary nucleation occurs during the crystallization of small molecules or proteins and self-assembled materials, as well as in protein self-assembly into fibrous structures. Indic

Common harmonic oscillator topologies, such as class-B and class-C, are typically unable to meet ultra stringent phase noise requirements, due to the exceedingly large capacitance (and, symmetrically, low inductance) that would be required in the parallel resonator. In this paper, we show that an oscillator making use of series resonators is ideally able to overcome this limitation, with the addit

Context. Due to their volatile nature, when sulphur and zinc are observed in external galaxies, their determined abundances represent the gas-phase abundances in the interstellar medium. This implies that they can be used as tracers of the chemical enrichment of matter in the Universe at high redshift. Comparable observations in stars are more difficult and, until recently, plagued by small number

Composite systems where quantum dots (QDs) are combined with other nanomaterials (e.g., gold nanorods) in aqueous solutions have attracted broad attention - both for their potential in applications and for studies of fundamental processes. However, high-quality QDs are typically prepared in organic solvents, and the transfer of QDs to an aqueous phase is needed to create the desired QD composites.

We explore to what degree movement together with facial features in a humanoid robot, such as eyes and mouth, can be used to convey mental states. Several animation variants were iteratively tested in a series of experiments to reach a set of five expressive states that can be reliably expressed by the robot. These expressions combine biologically motivated cues such as eye movements and pupil dil

This paper presents initial attempts to combine a humanoid robot with the teachable agent approach. Several design choices are discussed, including the decision to use a robot instead of a virtual agent and which behaviours to implement in the robot. A pilot study explored how the interaction with a robot seemed to influence children’s engagement as well as their attribution of mental states to a

DLE (Dry Low Emission) technology is widely used in land based gas turbines due to the increasing demands on low NOx levels. One of the key aspects in DLE combustion is achieving a good fuel and air mixing where the desired flame temperature is achieved without too high levels of combustion instabilities. To experimentally study fuel and air mixing it is convenient to use water along with a tracer

Världens befolkning ökar och i takt med det utbredningen av städer och urbana miljöer. Urbaniseringen är en extrem utmaning för många djurarter och antalet arter har minskat i takt med urbaniseringen. Trots detta finns det en hel del arter som tillsynes verkar blomstra i staden, mycket tack vara den rika tillgången till mat. Men så finns det en också baksida, nämligen de olika miljöföreningar som Urbanisation of natural habitats is rapidly intensifying and poses a potential global threat for wildlife. Thus, it is important to explore its impact on wildlife in order to understand the present and future threats and how resilient organisms are to them. Although many species decline in abundance or even disappear once an area is urbanised, some species, populations and/or individuals are able

The interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation. This interaction is part of a process that controls AQP2 apical membrane abundance in a vasopressin-dependent manner, allowing for urine volume adjustment. Vasopressin regulates phosphorylati

Since the last decade, development efforts by academia and industry for automated driving functions have increased significantly. Also, the European research project AdaptIVe is looking into this topic. Due to the large operation spaces and various complex situations that are covered by these functions, efforts for evaluation increase also significantly. Within AdaptIVe, a comprehensive evaluation

Presenterar Crusenstolpes erfarenheter av Lund och Lunds universitet med fokus på hans samtidsroman Tvenne äktenskap (1847).

In this letter, the fading statistics of wireless channels in high-speed railway cutting scenarios are characterized based on measurements. A multiple scattering model called second-order scattering fading (SOSF) is used to model the small-scale fading considering the influence of cuttings and bridges. The SOSF model can offer the possibility of analytical estimation for different fading severitie

The paper describes a multidisciplinary conceptual design of an axial compressor, targeting a three stage, high speed, high efficiency booster with a design pressure ratio of 2.8. The paper is outlined in a step wise manner starting from basic aircraft and engine thrust requirements, establishing the definition of the high speed booster interface points and its location in the engine. Thereafter,

This work focuses on the geotechnical behaviour of three foundation solutions for windmills. The first design is a traditional flat raft, the second is a deep flat raft, and the third is a conical raft. A comparative study between the traditional and the new solutions is performed. A conical raft is used to improve the resistance of the soil-structure interface. It is shown that a conical raft giv

The synthesis and characterization of three ligands and their respective heterobinuclear FeIIIZnII complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H2L2) was synthesized and i

Lead-based perovskite nanocrystals (NCs) have outstanding optical properties and cheap synthesis conferring them a tremendous potential in the field of optoelectronic devices. However, two critical problems are still unresolved and hindering their commercial applications: one is the fact of being lead-based and the other is the poor stability. Lead-free all-inorganic perovskite Cs3Bi2X9 (X=Cl, Br,