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Screening over Speech in Unselected Populations for Clinical Trials in AD (PROSPECT-AD) : Study Design and Protocol

Background: Speech impairments are an early feature of Alzheimer’s disease (AD) and consequently, analysing speech performance is a promising new digital biomarker for AD screening. Future clinical AD trials on disease modifying drugs will require a shift to very early identification of individuals at risk of dementia. Hence, digital markers of language and speech may offer a method for screening

Giant valleyZeeman coupling in the surface layer of an intercalated transition metal dichalcogenide

Spin–valley locking is ubiquitous among transition metal dichalcogenides with local or global inversion asymmetry, in turn stabilizing properties such as Ising superconductivity, and opening routes towards ‘valleytronics’. The underlying valley–spin splitting is set by spin–orbit coupling but can be tuned via the application of external magnetic fields or through proximity coupling. However, only

What can migration-law learn from cartography? : Some reflections on critical legal mapping as a method for understanding law

The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.

Construction and validation of a questionnaire to study engagement in informal second language learning

This article reports on the development and validation of the Informal Second Language Engagement questionnaire (ISLE) for capturing various aspects of learner engagement with informal second language practices. Whereas other questionnaires have primarily focused on learner behavior (the frequency, quantity, and diversity of informal activities in which learners engage), the ISLE additionally targ

Prevalence and morbidity of neck pain : a cross-sectional study of 3000 elderly men

Background: The purpose of this study is to determine the prevalence and morbidity of neck pain with or without cervical rhizopathy, upper extremity motor deficit and/or thoracolumbar pain in elderly men. Methods: We conducted a cross-sectional questionnaire study of 3,000 community-dwelling older men with a mean age of 75.4 ± 3.2 years (range 69–81) to determine if they had experienced neck pain

Comparison of the six-minute walk test performed over a 15 and 30 m course by children with cerebral palsy

Background: The aim of this study was to compare performance on the six-minute walk test (6MWT) performed over 15 m and 30 m courses by children and youths with cerebral palsy (CP). Methods: Children and youths with CP at Gross Motor Function Classification System levels I–IV performed the 6MWT in a straight 15 m-long corridor (first trial) and 30 m-long corridor (second trial). The intraclass cor

Nitrogen plasma passivation of GaAs nanowires resolved by temperature dependent photoluminescence

We demonstrate a significant improvement in the optical performance of GaAs nanowires achieved using a mixed nitrogen-hydrogen plasma which passivates surface states and reduces the rate of nonradiative recombination. This has been confirmed by time-resolved photoluminescence measurements. At room temperature, the intensity and lifetime of radiative recombination in the plasma-treated nanowires wa

Property Probes : Source Code Based Exploration of Program Analysis Results

We present property probes, a mechanism for helping a developer interactively explore partial program analysis results in terms of the source program, and as the program is edited. A node locator data structure is introduced that maps between source code spans and program representation nodes, and that helps identify probed nodes in a robust way, after modifications to the source code. We have dev

Honey bees are the most abundant visitors to Australian watermelon but native stingless bees are equally effective as pollinators

Despite the benefits of a diverse approach to crop pollination, global food production remains reliant on a low diversity of managed pollinators, especially the European honey bee (Apis mellifera). To facilitate more robust pollinator management and improve the resilience of the production system, it is necessary to understand regional variation in the pollination ecology of global food crops. Wat

Car careers : A socio-psychological evaluation of aspirational automobile ownership

There is a general consensus that private car ownership is a significant barrier to transport system change, specifically in regard to injuries, space, air pollutants, or greenhouse gas emissions. Observed changes in automobile characteristics also suggest that the system is becoming less sustainable, given trends towards larger cars with greater mass and horsepower. It is thus relevant to underst

POLITICAL ECONOMY of SECESSION : LESSONS from the EARLY YEARS of the IRISH FREE STATE

We apply insights from the political economy of secession to analyse the early years of the Irish Free State (IFS). The IFS was fortuitous in a debt settlement that enabled it to begin its existence debt free while also receiving financial assistance to quell civil unrest. Yet the IFS was unable to continue to provide the welfare spending inherited from the old regime thereby exacerbating inequali

Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life

Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Di

Synthesis of Minimax Adaptive Controller for a Finite Set of Linear Systems

The design of an adaptive controller with bounded L2-gain from disturbances to errors for linear time-invariant systems with uncertain parameters restricted to a finite set is investigated. The synthesis of the controller requires finding matrices satisfying non-convex matrix inequalities. We propose an approach for finding these matrices based on repeatedly linearizing the terms that cause the no