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Changes in the rat urinary bladder after the relief of outflow obstruction – tracing targets for treatment of persistent symptoms in patients

Studies on patients with bladder outflow obstruction who have undergone surgery for benign prostatic hyperplasia, successfully relieving the obstruction, have revealed a persistence of storage symptoms associated with detrusor overactivity (DO) in 20% to 40% of patients. To study the underlying mechanisms, we have used a common rat model of obstruction/de-obstruction, assuming that non-voiding con

Beamline Simulation for the NNBAR Experiment at the European Spallation Source

We have developed a sampling method for beamline simulations for the proposed NNBAR experiment at the European Spallation Source. The method is based on probability density evaluation and duct source biasing and enables the simulations of the entire NNBAR beamline with high statistics while also preserving correlations of the neutron tracks. Future efforts will focus on employing these methods for

Selling and over-selling Big Science in the knowledge society

In chapter 33, Hallonsten argues that the change in the historical context of Big Science, from the Cold War to contemporary innovation driven economies, has transformed its character and raised anew the issue of its legitimization. According to Hallonsten, the promotion of Big Science projects, as a result of their uncertain epistemic and technological payoff, often entails 'overselling' marketin

Hyperglycemia and insulin infusion in pancreatoduodenectomy : a prospective cohort study on feasibility and impact on complications

BACKGROUND: Hyperglycemia is a risk factor for postoperative complications but its impact on outcome after pancreatoduodenectomy (PD) is scarcely studied. This prospective cohort study aimed to assess the effect of continuous insulin infusion on postoperative complications and blood glucose, as well as to evaluate the impact of hyperglycemia on complications, after PD. MATERIALS AND METHODS: One h

Utilizing MRI, [18F]FDG-PET and [89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model : a multimodal imaging study

Objective: Accurate imaging biomarkers that indicate disease progression at an early stage are highly important to enable timely mitigation of symptoms in progressive lung disease. In this context, reproducible experimental models and readouts are key. Here, we aim to show reproducibility of a lung injury rat model, by inducing disease and assessing disease progression by multi-modal non-invasive

In situ XPS of competitive CO2/H2O absorption in an ionic liquid

Superbasic ionic liquids (SBILs) are being investigated as potential carbon dioxide (CO2) gas capture agents, however, the presence of H2O in the flue stream can inhibit the uptake of CO2. In this study a thin film of the SBIL trihexyltetradecylphosphonium 1,2,4-triazolide ([P66614][124Triz]) was deposited onto rutile TiO2 (110) using in situ electrospray deposition and studied upon exposure to CO

VAI-B : A multicenter platform for the external validation of artificial intelligence algorithms in breast imaging

Purpose: Multiple vendors are currently offering artificial intelligence (AI) computer-aided systems for triage detection, diagnosis, and risk prediction of breast cancer based on screening mammography. There is an imminent need to establish validation platforms that enable fair and transparent testing of these systems against external data. Approach: We developed validation of artificial intellig

The profession of research management and administration in Sweden

This chapter outlines the development of the Swedish Higher Education System that led to the evolution of the profession of research management and administration (RMA) in Sweden. Evolution from an informal network towards more formalised and structured work within the Swedish RMA community is highlighted. Discussion on the level of salaries development depending on the education level, gender, ex

Mean-field theory approach to three-dimensional nematic phase transitions in microtubules

Microtubules are dynamic intracellular fibers that have been observed experimentally to undergo spontaneous self-alignment. We formulate a three-dimensional (3D) mean-field theory model to analyze the nematic phase transition of microtubules growing and interacting within a 3D space, then make a comparison with computational simulations. We identify a control parameter Geff and predict a unique cr

Input and state constrained inverse optimal control with application to power networks

We study input and state constrained inverse optimal control problems starting from a stabilizing controller with a control Lyapunov function, where the goal is to make the controller an explicit solution of the resulting constrained optimal control problem. For an appropriate cost design and initial states for which a sublevel set of the Lyapunov function is contained in the state constraint set

Four new species of Parvoplaca (Teloschistales, Ascomycota)

The genus Parvoplaca is extended with four new species: P. candanii from Antarctica, P. lamprocarpa from Alaska, and P. macroborealis and P. tenebrosa from Oregon. Collections identified as P. tiroliensis are shown to form two independent clades when DNA was analyzed, but it is currently not clear which clade represents the species in a strict sense. Parvoplaca athallina has been considered an Ant

The lichen genera Gondwania and Transdrakea gen. nov. (Teloschistaceae) - speciation in three southern continents

Within the lichen family Teloschistaceae, a high number of genera are restricted to the extreme southern part of the Southern Hemisphere. The taxonomy and phylogeny of the southern genus Gondwania have been analyzed based upon fieldwork in Antarctica, Patagonia, New Zealand and Tasmania and subsequent studies including molecular methods. Five species are accepted in the genus Gondwanea including G

Rethinking change in Japan's security policy : punctuated equilibrium theory and Japan's response to the Russian invasion of Ukraine

Change in Japanese foreign and security policy has long been characterized as “incremental”. However, Japan’s response to Russia’s 2022 invasion of Ukraine provides an opportunity to reconsider this paradigm. In the aftermath of the 2014 annexation of Crimea, then-Prime Minister Abe Shinzō chose not to put Crimea on the agenda, prioritizing instead relations with Russia. However, Prime Minister Ki

Indicator accountability or policy shrinking? Multistakeholder partnerships in reviews of the sustainable development goals

The Sustainable Development Goals (SDGs) with their 169 targets and 231 indicators epitomise the trend of global governance by numbers. This article suggests the notion of a global “indicator reporting trajectory” that is shaped by three main elements: the politics of indicators, a reporting infrastructure and indicator advocacy. I propose that indicator reporting trajectories may result either in

The role of extracellular vesicle fusion with target cells in triggering systemic inflammation

Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules from donor to recipient cells. As a result, EV fusion leads to the modulation of cellular functions and has an impact on both physiological and pathological processes in the recipient cell. This study explores the impact of EV fusion on cellular responses to inflammatory signaling. O