Search results

Filter

Filetype

Your search for "*" yielded 534488 hits

The risk for venous thromboembolism and cardiometabolic disorders in offspring from thrombosis-prone pedigrees

Background: Most family studies on venous thromboembolism (VTE) have focused on first-degree relatives. Objectives: We took a pedigree-based approach and examined the risk of VTE and cardiometabolic disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: From the Swedish population, we identified a total of 482 185 pedigrees containing a mean of 14.2

Moderniserad maktdelning

Frihetstiden driver fram ett unikt statsskick i Sverige, världens första tryckfrihetslag och en rad civila rättigheter. Tankar om att makten ska var lojal mot folket, snarare än mot Gud och kungen, är upptakten till genomgripande samhällsomvälvningar som tar fart med den europeiska upplysningen.

Towards Human Rights 2.0? : A meta-theoretical analysis of the disruptions to human rights foundations by artificial intelligence

The use of artificial intelligence (‘AI’) is ubiquitous in society today. It has contributed towards advancements in diverse fields such as healthcare, transportation, public administration and in helping humanity to solve pressing challenges such as climate change. As AI increasingly plays a larger role within our daily lives and in society, it is inevitable that human rights issues will arise in

A superconvergent stencil-adaptive SBP-SAT finite difference scheme

A stencil-adaptive SBP-SAT finite difference scheme is shown to display superconvergent behavior. As proof of concept, applied to the linear advection equation, it has a convergence rate O(Δx4) in contrast to a conventional scheme, which converges at a rate O(Δx3).

Performance of the 2023 Duke-ISCVID diagnostic criteria for infective endocarditis in relation to the modified Duke criteria and to clinical management- reanalysis of retrospective bacteremia cohorts

BackgroundRevised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients with bacteremia and relate the diagnostic classification to IE-treatment.MethodsWe reanalyzed patient cohorts with Stapylococcus aureus, Staphylococcus lugdunensis,

Managing Data from Maritime Archaeology Investigations : AIR at Gribshunden

Maritime archaeology excavations, even in a more complex environment, have the same objectives and requirements as terrestrial ones: documenting digging operations to analyze data in the best way, interpreting it, and producing new knowledge for the benefit of multiple communities. 3D documentation and management methodologies have spread widely among practitioners; however, 3D comprehensive tools

Samhällsekonomiska effekter av att elektrifiera lastbilstransporter

Transportsektorn är en central och nödvändig del av det moderna samhället samtidigt som den också ger upphov till flera negativa samhällseffekter. Sådana effekter är till exempel emissioner av växthusgaser, partiklar och andra föroreningar som har en negativ påverkan på människors hälsa och miljön. Andra effekter är till exempel buller och olyckor som har en negativ effekt på människors hälsa. Syf

The effects of more informative grading on student outcomes

More granular grading scales provide a more accurate assessment of achievement and thus provide students with more informative feedback on their performance. Using Swedish administrative data and exploiting a natural experiment, we identify the effects of moving from a system with three passing grades to one with five passing grades. Students receiving more informative grades are less likely to gr

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation

Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT

Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection

In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction wi

The 10,000-year biocultural history of fallow deer and its implications for conservation policy

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con

DEVELOPMENT OF A HIGH INTENSITY NEUTRON SOURCE AT THE EUROPEAN SPALLATION SOURCE : THE HIGHNESS PROJECT

The European Spallation Source (ESS), presently under construction in Lund, Sweden, is a multidisciplinary international laboratory that will operate the world’s most powerful pulsed neutron source. Supported by a 3M Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) is now underway to develop a second neutron source below the spallation target. Compa