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Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema

Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na+ channel-transgenic (βENaC-Tg) mice demonstrated that airway surface dehydration, a key pathophysiological mechanism in cystic fibrosis (CF), caused emphysema in the absence of cigarette smoke exposure. However, the underlying mechanisms remain unknown. The aim of this study was to elucidate mec

MmWave Massive MIMO Processing in Demanding Environments - An Aircraft Cabin Deployment Study

Massive multiple-input multiple-output (MIMO) technology will continue playing an important role in beyond 5G wireless systems. Fully digital beamforming at the millimeter wave (mmWave) spectrum enables applications that require high data rates and low latency. This paper investigates the development and deployment of mmWave massive MIMO systems in an in-flight cabin environment, from both system

SARS‐CoV‐2 and pregnancy outcomes under universal and non‐universal testing in Sweden: register‐based nationwide cohort study

ObjectiveTo assess associations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and pregnancy outcomes considering testing policy and test-positivity-to-delivery interval.DesignNationwide cohort study.SettingSweden.PopulationFrom the Pregnancy-Register we identified 88 593 singleton births, 11 March 2020–31 January 2021, linked to data on SARS-CoV-2-positivity from the Pu

Visualising and calculating the smart city : a dialogue perspective

Purpose: This study addresses the implications of smart city development paths (techno-centric and human-centric) by investigating the evolution of a city strategy, focusing on how different actors in a dialogue centred on strategic planning documents for Saint Petersburg, Russia, visualised the smart city and then made it calculable. Design/methodology/approach: The authors conducted a case study

Overview of Postural Orthostatic Tachycardia Syndrome (POTS) for General Cardiologists

Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by excessive heart rate elevation upon standing or head-up tilt, in the absence of orthostatic hypotension. This debilitating condition affects primarily young to middle-aged individuals, particularly women, and substantially influences quality of life. The main presenting symptoms are lightheadedness, palpitations,

Relating the single particle soot photometer (SP2) signal response to soot maturity

Light absorbing carbonaceous aerosols produced from combustion span over a range of physicochemical properties. Soot is the most recognized species in this category and its formation process involves gradual maturation from amorphous young soot with a high hydrogen-to-carbon-ratio toward mature soot aggregates. In this work, the optical response of a single particle soot photometer (SP2) to electr

Comorbidities in women with polycystic ovary syndrome : a sibling study

BACKGROUND: Polycystic ovary syndrome (PCOS) has previously been associated with several comorbidities that may have shared genetic, epigenetic, developmental or environmental origins. PCOS may be influenced by prenatal androgen excess, poor intrauterine or childhood environmental factors, childhood obesity and learned health risk behaviors. We analyzed the association between PCOS and several rel

Qualities of Darkness

CDchorus and string orchestraI. Darkness shall cover the earth / Jesaja 60:2-3 ; II. How dark, O Lord / Thomas Morell ; III. A thick darkness / 2 Mosebok 10:21 ; IV. Total eclipse! / Newburgh Hamilton (efter John Milton)14 min

Coping with darkness : Residents' experience of reduced outdoor lighting in neighbourhoods

Despite ongoing replacement of old lighting installations with new energy-efficient light emitting diodes, the energy crisis has led to the implementation of strategies for reducing energy use for public outdoor lighting in neighbourhood environments. This would save money and reduce light pollution; however, the situations should be evaluated from the residents' perspective. This paper presents a

The new 1.5 GeV storage ring for synchrotron radiation : MAX II

The MAX laboratory at Lund University, Sweden, today operates an accelerator system consisting of a 100 MeV racetrack microtron and a 550 MeV storage ring (MAX I). At the moment (July 1994) a new storage ring MAX II is near completion and will start first injections within 2 months. This work gives an overview of the MAX II project including the first beamlines and a description of the accelerator

Compounds from aerial parts of Isodon lophanthoides and their effects of cytotoxicity and LPS-induced IL-1β and IL-10 production in RAW 264.7 macrophages

The bioassay-guided isolation of compounds from the aerial parts of Isodon lophanthoides (IL) resulted in the identification of five compounds (1–5). The chemical structures of 1–5 were determined through spectral analyses and compared to those identified in the literature to be 4-hydroxybenzoic acid (1), protocatechuic acid (2), rosmarinic acid (3), coetsoidin B (4), and coetsoidin A (5). Compoun

Separators and Membranes for Advanced Alkaline Water Electrolysis

Traditionally, alkaline water electrolysis (AWE) uses diaphragms to separate anode and cathode and is operated with 5–7 M KOH feed solutions. The ban of asbestos diaphragms led to the development of polymeric diaphragms, which are now the state of the art material. A promising alternative is the ion solvating membrane. Recent developments show that high conductivities can also be obtained in 1

Small-angle X-ray and neutron scattering applied to lipid-based nanoparticles : Recent advancements across different length scales

Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar assemblies, have gained significant attention in recent years, as versatile carriers for delivering drugs, vaccines, and nutrients. Small-angle scattering methods, employing X-rays (SAXS) or neutrons (SANS), represent unique tools to unveil structure, dynamics, and interactions of such particles on different length scales,

Smart Cities : Concepts, Practices, and Applications

This book discusses the various aspects of smart cities and their architecture along with the application of the latest technologies, including the Internet of Things (IoT) and artificial intelligence (AI). The concept of smart cities, their development, technological advancements, and issues related to them are discussed in detail.Smart Cities: Concepts, Practices, and Applications covers numerou

Assessing urban water demand-side management policies before their implementation : An agent-based model approach

In the context of climate change and increasing water scarcity, adopting water demand-side management (DSM) policies has become necessary. This study advocates for utilizing agent-based modelling (ABM) as a robust simulation tool to assess the impact of nonprice (nudges) and price (changes in increasing block tariff) measures on urban water use. Overcoming challenges posed by insufficient high-qua

Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function

PURPOSE: Anastomotic leakage after anterior resection for rectal cancer induces bowel dysfunction, but the influence on urinary and sexual function is largely unknown. This cross-sectional cohort study evaluated long-term effect of anastomotic leakage on urinary and sexual function in male patients. METHODS: Patients operated with anterior resection for rectal cancer in 15 Swedish hospitals 2007-2

Electrically active defects in Al2O3-InGaAs MOS stacks at cryogenic temperatures

The effects of defects in In0.47Ga0.53As/Al2O3/Ni metal-oxide-semiconductor (MOS) stacks at cryogenic temperatures are investigated. The MOS stacks exhibit a hysteresis in the capacitance-voltage (CV) curve, both at room temperature and at 100K, indicating the presence of effective charge capture/emission dynamics in the oxide even at cryogenic temperatures. Border traps (BTs) in the Al2O3 close t