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Uncovering scientific and multimodal literacy through audio description

The paper focuses on skills and competences applied in audio description (AD) of a Swedish multimodal popular scientific journal. The journal is made accessible for blind and visually impaired audiences by producing an audio version of its verbal and visual contents. The task of the sighted audio describer is to create a verbal description of the contents that activates internal images of the blin

Multiple splicing variants of the estrogen receptor are present in individual human breast tumors

Transcript variants of the estrogen receptor (ER) were investigated in 109 primary breast tumors using reverse transcription-polymerase chain reaction (RT-PCR) and primers allowing analysis of each internal exon. A high incidence of different ER variants was observed, each individual tumor often manifesting multiple variants coexisting with corresponding wildtype (wt) ER. These variants, by sequen

A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions

The best current model of breast cancer evolution suggests that most cancers arise from certain premalignant lesions. We have identified a common (34%) somatic mutation in the estrogen receptor (ER)-alpha gene in a series of 59 typical hyperplasias, a type of early premalignant breast lesion. The mutation, which affects the border of the hinge and hormone binding domains of ER-alpha, showed increa

Batch and Continuous Flow Production of 5-Hydroxymethylfurfural from a High Concentration of Fructose Using an Acidic Ion Exchange Catalyst

5-Hydroxymethylfurfural (HMF), a product of catalytic dehydration of C6 sugars, is a versatile and key renewable platform chemical. The possibility to use a high substrate concentration with high yield in a single-solvent system is one of the solutions to reduce solvent usage, energy consumption, reaction volume, and operating cost. A heterogeneous catalyst and single-solvent system were employed

Osteopontin and disease activity in patients with recent-onset systemic Lupus Erythematosus : Results from the SLICC Inception Cohort

Objective. In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Met

Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery

Background: LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns. Method: a prospective observational study was performed at Soder Hospital, Stockholm, Sweden dur

Effect of IOP on the visual field in ocuLar hypertension and glaucoma

The traditional opinion that increased intraocular pressure is the cause of glaucoma is controversial, probably mainly because of the fact that firm evidence for the value of pressure reduction is largely lacking. The present article reviews results from short term studies of visual fields before and after pressure reduction. It also reviews published and unpublished preliminary results from studi

Automatic computerized perimetry in the detection of neurological visual field defects. A pilot study

Forty-seven eyes from 25 patients with neurological disease were examined with an automatic computerized perimeter primarily intended for glaucoma. Manual kinetic and static perimetry with Goldmann's instrument was used for comparison. In 32 fields, the automatic method disclosed all defects that had been found by manual perimetry. Furthermore, it detected three small defects that had been missed

Use of aqueous two-phase systems for recovery and purification in biotechnology

Aqueous two-phase systems are generated by mixing aqueous solutions of two water-soluble polymers, or a polymer and a salt. These systems offer extremely mild conditions for separation of cells, organelles, proteins and other biomolecules, in biochemical processes. Considerable attention has been directed towards the use of the two-phase systems in several areas of biotechnology. The present paper

Meaning-making made aloud : From a printed version to an audio version of a multimodal popular science journal

First, the printed journal is analysed in accordance with Unsworth (1997), focusing on how the resources of text, images and graphics are deployed in scientific explanation and how the meaning is constructed by the visuals. Second, the interpretative process of meaning-making is uncovered by think aloud protocols. In order to produce an aural version of the complex text, the interpreter must asses