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Superconductor-nanowire devices from tunneling to the multichannel regime: Zero-bias oscillations and magnetoconductance crossover

We present transport measurements in superconductor-nanowire devices with a gated constriction forming a quantum point contact. Zero-bias features in tunneling spectroscopy appear at finite magnetic fields and oscillate in amplitude and split away from zero bias as a function of magnetic field and gate voltage. A crossover in magnetoconductance is observed: Magnetic fields above similar to 0.5 T e

Superoxide dismutase inspired immobilised Ni(II)-protected amino acid catalysts Synthesis, characterisation, and catalytic activity

Covalently anchored Ni(II)-C-protected amino acid (L-histidine, L-cysteine, and L-cystine) complexes inspired by the active site of the Ni-superoxide dismutase enzyme were synthesised using chloropropylated silica gel as support. The structural features of the surface complexes were studied by the Kjeldahl method and ICP-MS, mid/far IR, UV-vis diffuse reflectance, and X-ray absorption spectroscopi

Normalizing to GADPH jeopardises correct quantification of gene expression in ovarian tumours-IPO8 and RPL4 are reliable reference genes

Background: To ensure a correct interpretation of results obtained with quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR), it is critical to normalize to a reference gene with stable mRNA expression in the tissue of interest. GADPH is widely used as a reference gene in ovarian tumour studies, although lacking tissue-specific stability. The aim of this study was to id

Kontraster och nyanser. Svensk statsvetenskap i brytningstid.

Statsvetenskapliga förbundet fyller 40 år och det uppmärksammas med en skrift där svenska och nordiska samhällsforskare i ett drygt fyrtiotal uppsatser redovisar sin syn på svensk statsvetenskap. Några gör det genom personliga bildningsresor, andra försöker fånga de långa linjerna i en specialitets utveckling eller tar spjärn mot etablerade traditioner. Några skribenter argumenterar för nya empiri

Monitoring temporal trends in spatially structured populations: how should sampling effort be allocated between space and time?

Estimating temporal trends in spatially structured populations has a critical role to play in understanding regional changes in biological populations and developing management strategies. Designing effective monitoring programmes to estimate these trends requires important decisions to be made about how to allocate sampling effort among spatial replicates (i.e. number of sites) and temporal repli

Design, Verification and Application of IEEE 1687

IEEE 1687 (IJTAG) has been developed to enable flexible and automated access to the increasing number of embedded instruments in today's integrated circuits. These instruments enable efficient post-silicon validation, debugging, wafer sort, package test, burn-in, bring-up and manufacturing test of printed circuit board assemblies, power-on self-test, and in-field test. Current paper presents an ov

Structural Characterization of Nonionic Mixed Micelles Formed by C(12)EO(6) Surfactant and P123 Triblock Copolymer.

A structural characterization of mixed micelles formed in aqueous solution by the PEO-PPO-PEO triblock copolymer P123 and the nonionic surfactant C(12)EO(6) was carried out using various techniques, including ultralow shear viscosimetry, depolarized dynamic light scattering (VH-DLS), depolarized static light scattering (VH-SLS), and small-angle X-ray scattering (SAXS). The sphere-to-rod transition

Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics.

An amyloid form of the protein α-synuclein is the major component of the intraneuronal inclusions called Lewy bodies, which are the neuropathological hallmark of Parkinson's disease (PD). α-Synuclein is known to associate with anionic lipid membranes, and interactions between aggregating α-synuclein and cellular membranes are thought to be important for PD pathology. We have studied the molecular

Developing General Practice: The Role of the APO method

Abstract General practice is a broad and multifaceted field of knowledge. Political steering instruments declare that general practice and primary care are characterized by a holistic perspective on the individual, with quality, accessibility, continuity, and cooperation being important factors. For the last few decades, quality assurance has been in focus in Swedish health care. Inspiration has c

Elastic Net Regularized Logistic Regression using Cubic Majorization

In this work, a coordinate solver for elastic net regularized logistic regression is proposed. In particular, a method based on majorization maximization using a cubic function is derived. This to reliably and accurately optimize the objective function at each step without resorting to line search. Experiments show that the proposed solver is comparable to, or improves, state-of-the-art solvers. T

Integrating fluvial processes into the global Si cycle

Popular Abstract in Swedish Kisel (Si) förekommer i alla naturliga vatten i form av löst kisel och är ett näringsämne för många växt- och djurarter. Löst kisel kommer ursprungligen från kiselhaltiga mineral som har vittrat. Vid vittringen går det åt koldioxid (CO2) och på så vis finns det ett samband mellan omsättningen av kisel och kol. Både upptag och vittring av kisel bidrar till att fördelningSilicon (Si) is ubiqutious in natural waters as dissolved silica (DSi) and is used as a nutrient by many plant and animal species. DSi ultimately derives from the weathering of silicate minerals, a process which also consumes atmospheric CO2 and couples the silicon and carbon cycles. These processes, among others, impart observable fractionations to the stable isotopes of silicon, which makes the

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation

Background: The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphomas and indicates that epigenetic drugs may be used to re-express this tumour su

Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties

Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. Signals supporting CAF function are thus emerging as candidate therapeutic targets in the tumor microenvironment. The chemokine CXCL14 is a potent inducer of CAF protumorigenic functions. This study is aimed at learning how the protumoral functions of CXCL14-expressing CAF are maintained. We found that the nitric oxide synt

Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome - a randomized study.

Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the

Laser-induced breakdown spectroscopy in a partially premixed turbulent jet flame

A new approach for studying mixing and combustion phenomena in turbulent partially premixed flames using laser-induced breakdown spectroscopy (LIBS) is demonstrated. Setting the laser pulse energy just above the breakdown threshold in the cold gas allows statistical data to be obtained concerning the probability of finding cold or hot gas inside the measurement volume. Moreover, a compositional an

Effect of Natural and Semisynthetic Pseudoguianolides on the Stability of NF-κB:DNA Complex Studied by Agarose Gel Electrophoresis.

The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodimeric complex of RelA and p50 subunits that interact with the DNA, regulating the expression of several genes; its dysregulation can trigger diverse diseases including inflammation, immunodeficiency, and cancer. There is some experimental evidence, based on whole cells studies, that natural sesquiterpene lac