The objective of this study is to explore the following: (1) the impact of two different initial doses and cumulative 2-year dose of rituximab (RTX) on drug adherence and predictors of adherence to treatment in rheumatoid arthritis (RA) patients in an observational clinical setting, (2) immunoglobulin levels (IgG/IgM/IgA) during repeated treatment and their relation to infections, and (3) developm

Background: Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is increasing due to widespread use of central venous catheters in patients with cancer and other chronic diseases. The safety and efficacy of using new direct acting oral anti coagulant

Background: The risk of cancer is increased and affects survival after lung transplantation (LTx), but has not been well characterized in COPD. We aimed to evaluate the incidence and prognosis of cancer following LTx for COPD. Methods: A prospective, population-based study of patients undergoing LTx for end-stage COPD at the two transplantation centers in Sweden between 1990−2013, with follow-up f

The reassigned spectrogram can be used to improve the readability of a time-frequency representation of a non-stationary and multi-component signal. However for transient signals the reassignment needs to be adapted in order to achieve good localisation of the signal components. One approach is to scale the reassignment. This paper shows that by adapting the shape of the time window used with the

Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, an

Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from l-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylargini

Following the recent Global Carbon Project (GCP) synthesis of the decadal methane (CH4) budget over 2000-2012 (Saunois et al., 2016), we analyse here the same dataset with a focus on quasi-decadal and inter-annual variability in CH4 emissions. The GCP dataset integrates results from top-down studies (exploiting atmospheric observations within an atmospheric inverse-modelling framework) and bottom-

The development of good writing skills is fundamental not only to publish scientific results, but also to have a deeper understanding of complex subjects. However reports from the Swedish Higher Education Authority from 2012-2015 suggest that engineering students at Lund University have unsatisfactory academic writing skills. Our paper investigates how students of the Faculty of Engineering at Lun

This paper proposes a novel Doppler penalty kernel used in the computation of multitapers corresponding to the Wigner-Ville distribution. The resulting multitaper spectrogram will approximately fulfil the time-frequency concentration of the Wigner-Ville distribution but also suppress the cross-terms outside a signal dependent Doppler bandwidth, making the penalty kernel appropriate for linear freqThis paper proposes a novel Doppler penalty kernel used in the computation of multitapers corresponding to the Wigner-Ville distribution. The resulting multitaper spectrogram will approximately fulfil the time-frequency concentration of the Wigner-Ville distribution but also suppress the cross-terms outside a signal dependent Doppler bandwidth, making the penalty kernel appropriate for linear freq

This thesis addresses the application of spatial approaches to disease surveillance and control from three different aspects. First, temporal trends, geographical distribution and spatial pattern of cardiovascular disease admission rates were explored on a national level in Sweden. Global Moran’s I was used to explore the structure of patterns and Anselin’s local Moran’s I was applied to explore t