Development of inhibitory antibodies to infused factor VIII (FVIII) concentrates continues to be the most serious complication of haemophilia A management. Induction of immune tolerance by administering high doses of FVIII concentrate (antigen) and prothrombin complex concentrates to control bleeding was originated in the 1970s in Bonn, Germany, by Dr Hans-Hermann Brackmann, and became known as th

Ozone vapor, O3, is here visualized in a gliding arc discharge using photofragmentation laser-induced fluorescence. Ozone is imaged by first photodissociating the O3 molecule into an O radical and a vibrationally hot O2 fragment by a pump photon. Thereafter, the vibrationally excited O2 molecule absorbs a second (probe) photon that further transits the O2-molecule to an excited electronic state, a

Research within the area of selective energy transfer (SET) on how resonance develops between a specific vibration within a catalyst system and a corresponding vibration within a reacting system that resonates with it is discussed here. The catalyst system is assumed to donate one or more vibrational quanta to the reacting system. The term ‘specific vibration’ refers to vibration of a type involvi

Purpose: Head trauma is common in the emergency department. Identifying the few patients with serious injuries is time consuming and leads to many computerized tomographies (CTs). Reducing the number of CTs would reduce cost and radiation. The aim of this study was to evaluate the characteristics of adults with head trauma over a 1-year period to identify clinical features predicting intracranial

The planetary changes associated with the Anthropocene, including climate change and extinction of species, pose severe threats to civilization, humanity, and the natural world as we know it. They also pose special challenges to the human imagination. To meet these challenges, climate change communicators use narratives. Nonfiction books intended for a general audience employ two radically differeThe planetary changes associated with the Anthropocene, including climate change and extinction of species, pose severe threats to civilization, humanity, and the natural world as we know it. They also pose special challenges to the human imagination. To meet these challenges, climate change communicators use narratives. Nonfiction books intended for a general audience employ two radically differe

In this paper we suggest an algorithm for estimation of the parameters detailing Oscillating Gaussian functions. The different components of the signal are first detected in the spectrogram. After this we exploit the fact that a Gaussian function may be perfectly reassigned into one single point given a correct scaling factor, where this scaling factor is a function of the unknown shape parameter

The understanding of consistent individual differences in behavior, often termed “personality,” for adapting and coping with threats and novel environmental conditions has advanced considerably during the last decade. However, advancements are almost exclusively associated with higher‐order animals, whereas studies focusing on smaller aquatic organisms are still rare. Here, we show individual diff

Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of complement, the C3 convertase. However, the reliability of assays detecting these autoantibodies is limited.

To promote a more sustainable agricultural production, the European Commission implemented direct payments that require farmers to implement greening measures aimed at reducing negative effects of agriculture on the environment and biodiversity. These greening measures (including fallows and permanent grasslands) have been criticised for their potential inability to conserve biodiversity and promo

The unified knowledge on power converter design and manufacturing technology establishes a powerful tool, where the cost and topology realization can be analyzed simultaneously. This paper collects the design practice and cost estimation of various components in a power electronics converter and unites that to a choice of the assembling and manufacturing processes and resulting cost of the complet

BB rats lose >50% of their islet sympathetic nerve terminals soon after diabetes onset, markedly impairing the glucagon response to activation of these nerves. In this study, we sought evidence that this degree of disease-induced nerve terminal damage affected their neuronal cell bodies. Increased galanin expression was used as a marker of the change of phenotype that occurs in neuronal cell bodie

Nitrogenase activity (NA) in shallow‐water (< 1 m) sediments was investigated at 60 randomly selected sites along a 150 km stretch on the brackish‐water Swedish west coast, without targeting any specific type of sediments, such as microbial mats. Benthic nitrogen (N) fixation and diazotrophs (nifH genes) were found at all sites, regardless of the presence of cyanobacterial or microbial mats. The m

Introduction: Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. Mater

Since the mid 1970's, when Adey discovered that extremely-low-frequency electromagnetic field (ELF EMF) may affect the calcium ions efflux from various cells, bioeffects of non-ionizing radiation (NIR) have become the subject of growing interest and numerous research projects. At present, the fact that NIR exerts both stimulatory and inhibitory effects on different physiological cellular parameter

In this article, we introduce and demonstrate the concept-metaphor of broken data. In doing so, we advance critical discussions of digital data by accounting for how data might be in processes of decay, making, repair, re-making and growth, which are inextricable from the ongoing forms of creativity that stem from everyday contingencies and improvisatory human activity. We build and demonstrate ouIn this article, we introduce and demonstrate the concept-metaphor of broken data. In doing so, we advance critical discussions of digital data by accounting for how data might be in processes of decay, making, repair, re-making and growth, which are inextricable from the ongoing forms of creativity that stem from everyday contingencies and improvisatory human activity. We build and demonstrate ou

To increase the understanding of wind turbine noise on sleep, human physiological reactions need to be studied in a controlled laboratory setting. The paper presents an outdoor-indoor noise level difference as a function of frequency, applicable to creating wind turbine indoor sounds with the outdoor sounds as input. For this, a combination of measurement data and modeling results has been used. T

An important part of the justification process is assessment of the radiation risks caused by exposure of a patient during examination. The authors developed official national methodology both for medical doctors and sanitary inspectors called ‘assessmentof radiation risks of patients undergoing diagnostic examinations with the use of ionizing radiation’. The document addressespatients of various

Background: Botulinum toxin A (BTX-A) has been used to reduce spasticity in children with cerebral palsy (CP) for decades. The purpose of this study was to analyze to what extent BTX-A treatment was used to treat spasticity in a total population of children with CP. We investigated 1) the use of BTX-A in relation to age, sex, and Gross Motor Function Classification System (GMFCS) level, 2) the mos