Search results

Background The estrogen receptor alpha (ERa), encoded by ESR1, is overexpressed in 75 – 80 % of breast cancers. Treatments targeting ERa are challenged by development of resistance due to loss of ERa expression. It is crucial to increase understanding of regulatory mechanisms of ERa expression and identify alterations in these mechanisms. Modifications of miRNA target sites in ESR1 3’ UTR or meth

Bakgrund: Behandling av huvud-halscancer kan medföra komplikationer, däribland laryngofaryngela ödem. Laryngofaryngeala ödem kan leda till påtagliga konsekvenser för patienter. Laryngofaryngeala ödem kan resultera i försämrad funktion tal, röst och sväljning samt försämrad livskvalitet. Ödem är även associerat med kronisk inflammation vilket kan leda till fibros. Det är därför viktigt att i tidigtIntroduction: Treatment of head and neck cancer may lead to complications, among these the development of laryngopharyngeal edema. Laryngopharyngeal edema may result in loss of function regarding speech, voice and swallowing as well as decreased quality of life. Edema is also associated with chronic inflammation which may lead to fibrosis. Therefore early intervention is of importance for this pat

Glioblastoma (GBM) is the most aggressive type of primary brain tumours in adults and accounts for 49.1% of the cases. Most of the cases are recorded in elderly patients, but GBM affects people of all age groups. Till date no cure has been found. Previous data has suggested that pericytes might influence tumour invasion by interacting with tumour cells by the secretion of or interaction with extra

SARS-CoV-2 Antagonism of IFN Signalling Pathways. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The rapid spread of the virus raised concerns for the major gap in knowledge of infectious viral diseases. Understanding how the virus modulates host innate immune responses is crucial for development of therapeutic strategie

Technological advancements have significantly transformed the healthcare landscape, particularly with the emergence of technological augmentation in healthcare settings. This research aims to investigate the impact of technological augmentation on nurse skills. The study seeks to analyze how integrating the Electronic Health Records affects the skill sets of nurses. The research methodology involv

Understanding how organisms respond to their environment is essential in an increasingly fast changing world. For many organisms, phenotypic plasticity is the first response to environmental change. I investigated 1) if there are consistent differences in plastic response in three environmental gradients (Nitrogen/Phosphorus ratio, salinity and temperature) and 2) quantified the variation in react

The Role of Polo Like Kinase-1 in Ovarian Cancer Progression Ovarian cancer it the most fatal gynecologic cancer, an urgent issue as it is also the eight most common cancer in the global female population. The poor prognosis of the disease is largely attributed to ineffective screening methods, asymptomatic or unspecific disease manifestation, insufficient treatment options and high occurrence of

This study investigates the potential for energetic self-reliance in an integrated biore- finery, the Earth Power Lodge (EPL), which aims to convert waste into valuable by- products through bio- and thermochemical conversion processes. The primary questions addressed include assessing the necessity of external propane to sustain the pyrolysis process and the net energy output of the ThermoChemical

This thesis examines the strategies adopted and the challenges professionals face while providing cognitively disabled youths with sexual education. The study was conducted via qualitative interviews of professionals working with cognitively disabled youth, ranging between teachers, youth club workers, and sexual health educators. The thesis’ chief findings showed that professionals adopted the st

Coming from a predominantly Catholic country, Lithuanian immigrants in Scandinavia find themselves in a contrasting Protestant context of the host societies. This ethnographic study of diasporic Lithuanian communities and their transnational Catholic practices aims to understand what motivates immigrant Lithuanians to join the church in Sweden or Norway and whether this foreign environment influen

The aim of this study was to investigate how hospital counselors in specialized palliative care reason about their discretion and their professional role in the multi-professional team, in order to deepen the understanding of their professional role as well as the psychosocial work that is carried out within the medical context. The methodology was based on a qualitative approach using seven semi-

An ERP implementation is an intricate process that requires comprehensive planning, designing and execution. The implementation encompasses virtually all aspects of an organization’s business processes, as well as the organizational culture. A successful ERP implementation are affected by numerous modules that needs to be thoroughly considered for an optimal solution. User involvement is one of th

This thesis investigates the characteristics of the current water management system of Hojancha, a small canton in the Guanacaste region of Costa Rica. The canton of Hojancha in Costa Rica is the subject of this research because there, an effective community-led water management initiative has been put in place. Still, future water stress and conflicts are likely to further develop. Understanding

The aim of this study is to investigate how newspaper articles from the Swedish newspaper Expressen have presented cannabis in the years 1992 and 2022. The objective was to compare the coverage between these years. After applying selection criteria and random selection, 70 articles were chosen for analysis. The method on which this work is based is qualitative text analysis. The content from the a

The objective of this study was to investigate what are the most common types of digital violence that social workers come across and how they assess their seriousness. Our research questions were: 1/ What types of digital violence exist and how common are they? 2/ How do social workers assess the severity of the types of violence? 3/ Does the ranking and seriousness assessment differ between

This paper seeks to provide insights into the effects of carbon border tariffs and to offer guidance for policymakers. The focus is directed towards the steel sector - a major contributor to carbon dioxide emissions, where production practices vary significantly among countries, leading to differences in pollution levels. Our primary focus is on the proposed carbon border tariff by the United Stat

According to the 1951 Refugee Convention, it is the state’s responsibility to protect and provide basic services to the refugees within their border. However, even if ratified to the Convention, it is common that the state decides to relinquish its responsibilities for various reasons. In Trinidad and Tobago, no national refugee policy has been adopted since the ratification of the 1951 Refugee Co

This bachelor thesis studies the probabilities of dice rolls in tabletop roleplaying games, to see if any correlation can be found between the system and the desired theme for the game. Due to the growing popularity of tabletop roleplaying, it is a field worth exploring, as it touches the lives of many people around the world. Four different roleplaying systems is studied, and through comparing pr

Oats are renowned for their high dietary fibre content and numerous health benefits. As the demand for nutritious diets increases and oats become a more popular dietary staple, it is crucial to have a thorough understanding of the various types of dietary fibre present in oats. To explore the correlation between resistant starch (RS) levels and amylose content in high amylose oat lines, a molecula