Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. Using single cell RNA sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons w

Kursbok om Alternativ och Kompletterande Kommunikation (AKK), med fokus på kommunikationshjälpmedel, praktiska metoder och förhållningssätt. Boken ingår i ett kursmaterial i tre delar, för utbildning av personliga assistenter och andra som arbetar och lever nära ungdomar och vuxna med omfattande kommunikationssvårigheter på grund av funktionsnedsättning.

Background Lifestyle exposures play a major role in the development of disease, yet people vary in their susceptibility. A critical step towards precision medicine is identifying individuals who are resilient or sensitive to the environment, and, assess whether the allocation to these predicted groups are more or less likely to develop cardiometabolic disease.Methods We have used repeated data fro

The present study aims to assess the over-time association of ∼300 lifestyle exposures with nine cardiometabolic traits with the ultimate aim of identifying exposures/exposure groups that could inform lifestyle interventions aiming at controlling cardiometabolic diseases. The analyses were undertaken in a longitudinal sample comprising >31000 adults living in northern Sweden. Linear mixed models w

Metod- och övningsbok om Alternativ och Kompletterande Kommunikation (AKK), med fokus på kommunikationshjälpmedel, praktiska metoder och förhållningssätt. Boken ingår i ett kursmaterial i tre delar, för utbildning av personliga assistenter och andra som arbetar och lever nära ungdomar och vuxna med omfattande kommunikationssvårigheter på grund av funktionsnedsättning.

With the emergence of children’s literature in the modern sense in the eighteenth century, new genres of literature especially intended for young readers came into being. In addition, several well established genres, one of which was the Aesopic fable, were adapted and redirected to augment the growing children’s library. Focussing partly on a Scandinavian context, this article outlines fable’s ev

In order to understand species’ sensitivity to habitat change, we must correctly determine if a species is associated with a habitat or not, and if it is associated, its degree of specialization for that habitat. However, definitions of species’ habitat association and specialization are often static, categorical classifications that coarsely define species as either habitat specialists or general

Current land use and climate change pose a threat to the continued provision of ecosystem services expected from terrestrial land cover. Studies on past land-cover responses to such changes provide valuable information for future decisions. The hemiboreal zone, situated between temperate and boreal biomes, is a natural sensitivity hotspot for land cover change: it contains a continuous distributio

Hydrogen chloride (HCl) monitoring during combustion/gasification of biomass fuels and municipal solid waste, such as polyvinyl chloride (PVC) and food residues, is demanded to avoid the adverse effect of HCl to furnace operation and to improve the quality of the gas products. Infrared tunable diode laser absorption spectroscopy (IR-TDLAS) is a feasible nonintrusive in-situ method for HCl measurem

The recently discovered giant exoplanet HR5183b exists on a wide, highly eccentric orbit (a = 18 au, e = 0.84). Its host star possesses a common proper-motion companion which is likely on a bound orbit. In this paper, we explore scenarios for the excitation of the eccentricity of the planet in binary systems such as this, considering planet-planet scattering, Lidov-Kozai cycles from the binary act

Landslides often cause significant casualties and economic losses, and therefore landslide susceptibility mapping (LSM) has become increasingly urgent and important. The potential of deep learning (DL) like convolutional neural networks (CNN) based on landslide causative factors has not been fully explored yet. The main target of this study is the investigation of a GIS-based LSM in Zanjan, Iran a

Prevent and manage crises in anesthesiology gives anesthesiologists and allied professionals an overview of the non-technical and technical skills and knowledge that may be required at very short notice, at almost any time of the day.

Ecological stability encompasses multiple dimensions of functional and compositional responses to environmental change. Though no single stability dimension used in isolation can fully reflect the overall response to environmental change, a common vulnerability assessment that integrates simultaneously across multiple stability components is highly desirable for ecological risk assessment. We deve

Older people and people with functional limitations are recognized as vulnerable groups when it comes to evacuation. Previous studies have focused mostly on the quantitative aspects of their physical characteristics, such as movement speeds. This study explores the perspectives on egressibility of older people with functional limitations. This was achieved by reflexive thematic analysis of semi-st