Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by brain aggregation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins. Extracellular vesicles (EVs) can be isolated and studied for potential roles in disease. While several studies have tested plasma-derived EVs in AD, few have analyzed EVs from cerebrospinal fluid (CSF), which are potentially mo

Relationer med nära vuxna är viktiga för barns utveckling. Forskning om känslomässig trygghet, så kallad ”anknytning”, mellan barn och förälder har visat att hur föräldrar bemöter barnets behov av tröst och närhet inverkar på barnets sätt att hantera känslomässig stress och navigera sociala relationer. Även andra omsorgspersoner i ett barns vardagsliv kan bli anknytningsfigurer för barnet, såsom pCurrent child developmental research encourages a more systemic understanding of attachment-related relationship-building. As many young children spend a substantial part of their daily life in professional childcare, e.g., “preschool”, interactions with teachers at preschool are of particular interest in this respect. In bridging the developmentally important contexts of home and preschool for th

Background Implementation of evidence-based practice (EBP) in child and adolescent mental health services (CAMHS) is a priority to improve service delivery and outcomes. Clinicians’ EBP attitudes are likely to play a crucial role in implementation but are poorly understood. This study aimed to assess variation in EBP attitudes in a large national sample of CAMHS clinicians in Sweden, and to compar

In this paper, we discuss the ethical concerns that may arise from the synthesis of human DNA. To date, only small stretches of DNA have been constructed, but the prospect of generating human genomes is becoming feasible. At the same time, the significance of genes for identity, health and reproduction is coming under increased scrutiny. We examine the implications of DNA synthesis and its impact

Identification of preferential flow-paths, such as fractures, is required for various issues in geosciences. When chemicals are injected into the subsurface, monitoring the resulting structural and chemical changes remains a challenge. The ability of geophysical tomography to tackle this problem is not fully explored due to the lack of numerical methods suitable for modeling narrow structures. We

The Book of Hours of Galeazzo Maria Sforza, V. Duke of Milan (Vienna, Austrian National Library, Codex 1856), the so-called Black Hours, is a Flemish illuminated manuscript with silver and gold ink on black coloured parchment from the third quarter of the fifteenth century. The severe deterioration of the parchment by the black colourant resulted in brittleness and numerous losses. This paper desc

With the increased interest in lignin valorization, the analytical challenge to separate a complex mixture of a vast number of phenolics has made chromatography an indispensable step in lignin analysis. High-resolution separations, such as gas chromatography, reversed-phase liquid chromatography and supercritical fluid chromatography have typically been targeting low-molecular-weight compound

IntroductionResearch evidence suggests that radiographers often rely on previous training, traditional practices, work experience and protocols developed within the department rather than up-to-date research-based evidence in their daily practice. The aim of the study was to investigate factors that might impact the development of evidence-based practice amongst radiographers in clinical public se

A permanently available molecular-beam injection setup for controlled molecules (COMO) was installed and commissioned at the small quantum systems (SQS) instrument at the European x-ray free-electron laser (EuXFEL). A b-type electrostatic deflector allows for pure state-, size-, and isomer-selected samples of polar molecules and clusters. The source provides a rotationally cold (T ≈ 1 K) and dense

Neutron scattering techniques have been employed to investigate two key areas of condensed matter physics: superconductivity and quantum magnetism. The experimental studies span two distinct areas: two-band superconductors, where we explore the interplay between superconducting anisotropy and vortex structure, and quasi-one-dimensional (quasi-1D) spin chains, where we investigate the magnetic exci

Background. Aortic stiffness is a marker of vascular ageing. Non-conventional risk markers reflecting vascular ageing are largely unexplored. We aimed to investigate the relationship between self-perceived age (SPA) and self-rated health (SRH) with aortic stiffness in the general population. Methods. Cross-sectional assessment of 3760 participants from two Swedish population-based cohorts (mean ag

This chapter discusses the legal conceptualization of greenhouse gas emissions from transnational production. Using global value chain theory as our starting point, we show how these emissions can be understood on the level of law through a combination of private governance, regulation and private law doctrine. We propose that this approach provides a useful heuristic tool for identifying, apporti

BackgroundIn a previous phase II trial, intraperitoneal local anaesthetics shortened the time interval between surgery and adjuvant chemotherapy, an endpoint associated with improved survival in advanced ovarian cancer. Our objective was to test this in a phase III trial.MethodsA double-blind, phase III parallel superiority trial was conducted at two university hospitals in Sweden, within a public

Jämställdhet är en högst relevant aspekt för en mer hållbar transportsektor. Det finns genomgående stora skillnader mellan könen vad gäller såväl resvanor och beteende som attityder och värderingar. Skillnaderna i resvanor är så stora att enbart skillnaderna i bilanvändning skulle minska energianvändningen från transportsektorn med en femtedel om män i genomsnitt reste som kvinnor i genomsnitt. Kl