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Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man

Extracellular nucleotides such as ATP and UTP are released by activation of platelets and ischemic tissue injury. The aim of the present study was to investigate whether ATP and UTP can induce acute tPA release from the vascular endothelium in vivo. Nine healthy subjects were studied in a perfused-forearm model during stepwise intraarterial infusions of ATP and UTP (10-200 nmol/min), and UTP durin

Radiative lifetime measurements and oscillator strength determination for transitions in singly ionized praseodymium (Pr II)

New radiative lifetimes for 20 levels of Pr II have been measured using the time-resolved laser-induced fluorescence (LIF) technique. The combination of these experimental values with theoretical branching fractions (BF) obtained with the pseudo-relativistic Hartree-Fock (HFR) approach has allowed us to determine oscillator strengths and transition probabilities for about 150 lines appearing in th

Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L

The Cockcroft-Gault formula is often used to calculate the glomerular filtration rate (GFR) from plasma creatinine results. In Sweden this calculation is not usually done in the laboratory, but locally in the wards. These manual calculations could cause erroneous results. In several studies plasma cystatin C has been shown to be superior to plasma creatinine for estimation of GFR. One limitation o

Breaking the boundaries of careers. A study of the mobility effects of a program for career councelling

In this paper a study of a career planning project launched by the Swedish National Tax Board is reported. The project, named Propeller, was initiated in 1998 as a joint endeavour among three agencies: the Swedish National Tax Board, the Regional Stockholm Tax Office and the Enforcement Authority. The intention was to create a common micro labour market in order to encourage employees to become mo

Characterization of a PEO-PPO-PEO block copolymer system

The investigated EO27-PO39-EO27 triblock copolymer, Pluronics P-85, is a nonionic surface-active agent which has a monomeric molecular weight of 4600, of which 500% corresponds to the PEO component. P-85 exist in complex states of aggregation in aqueous solution. Monomers, micelles and larger aggregates (clusters) coexist at lower concentrations in relative proportions which depend on temperature.

3D absorbed dose calculations based on SPECT: Evaluation for 111-In/90-Y therapy using Monte Carlo simulations.

A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstructi

Transcriptional networks in neuroblastoma and breast cancer

Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. Neuroblastoma is a childhood tumour that arises in the develop

Effect of electron-phonon interaction on electron conductance in one-dimensional systems

We have studied the effect of electron-phonon interaction on the electronic transport in a one-dimensional wire where both electrons and phonons are quantum confined. We found substeps appeared in the quantized electron conductance, and the step height depends on the electron-phonon coupling strength. With increasing temperature, the substep structure smooths out. Dependent on the transmission pro

Imagining China’s Madrid in Manchuria: The Communist Military Strategy at the Onset of the Chinese Civil War, 1945-46

This article is an interdisciplinary study of CCP military decision making at the outset of the Civil War. The historical phenomenon of the Communists’ invocation of “Madrid” is studied in the context of the Chinese civil war in Manchuria, particularly the battle of Sipingjie. The strategic culture of the Communist leaders is discussed thematically in terms of their desire for a decisive battle, t