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The Handbook of Evolutionary Economic Geography
Pediatric emergency department management benefits from appropriate early redirection of nonurgent visits.
Overcrowding at pediatric emergency departments (EDs) may result in delayed clinical management and higher risks of medical error. This study was designed to prospectively evaluate what parents of sick children seek emergency care for and how these patients are being assessed and managed.
Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat.
Clinical and experimental results have revealed a fundamental role of calcitonin gene-related peptide (CGRP) in primary headaches. CGRP is widely expressed in neurons both in the central nervous system (CNS) and in peripheral sensory nerves. In the CNS there is a wide distribution of CGRP-containing neurons with the highest levels seen in striatum, amygdale and cerebellum. Moreover, in acute attac
First precise U-Pb baddeleyite ages of 1500 Ma mafic dykes from the Sao Francisco Craton, Brazil, and tectonic implications
The Sao Francisco Craton (SFC) is an Archaean-Proterozoic craton that hosts a significant number of mafic intrusions. Previous attempts to date the igneous emplacement of these rocks are limited to a few poor precision Rb-Sr and Sm-Nd isochrons. Here, dykes from the Curaca belt, in the northeastern portion of the craton, as well as from the Chapada Diamantina region in the central part, were dated
Treatment Patterns and Outcomes in Patients Undergoing Percutaneous Coronary Intervention Treated With Prasugrel or Clopidogrel (from the Swedish Coronary Angiography and Angioplasty Registry [SCAAR])
Large real-world registry data are important for understanding the current use and outcomes of novel therapies. The aim of this study was to assess treatment patterns and outcomes in patients who underwent percutaneous coronary intervention (PCI) with prasugrel or clopidogrel. Consecutive patient data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) for 2010 and 2011 were use
Investigating boundaries of survival, growth and expression of genes associated with stress and virulence of Listeria monocytogenes in response to acid and osmotic stress.
The objective of this study was to correlate the relative transcription of Listeria monocytogenes (strains C5, 6179) stress- (gad2, sigB) and virulence- (prfA) associated genes following habituation at twenty-five pH (4.8, 5.0, 5.2, 5.5, 6.4) and NaCl (2, 4, 6, 8, 10% w/v) combinations at 7 °C, with the survival against subsequent exposure to severe acid stress (pH 2.0 at 37 °C). Our findings poin
Gold-free GaAs/GaAsSb heterostructure nanowires grown on silicon
Growth of GaAs/GaAsSb heterostructure nanowires on silicon without the need for gold seed particles is presented. A high vertical yield of GaAs nanowires is first obtained, and then GaAsxSb1-x segments are successfully grown axially in these nanowires. GaAsSb can also be integrated as a shell around the GaAs core. Finally, two GaAsSb segments are grown inside a GaAs nanowire and passivated using a
A new reimbursement system for innovative pharmaceuticals combining value-based and free market pricing.
Sweden has experienced a national value-based pricing (VBP) system for innovative outpatient drugs operated by the Pharmaceutical Benefits Board - LFN (now called the Dental and Pharmaceutical Benefits agency - TLV) since 2002. VBP has the character of a monopoly system, leading to reimbursement decisions where usage of new medicines is limited to subgroups and not the population for which the dru
Enzymatic hydrolysis of Canna indica, Manihot esculenta and Xanthosoma sagittifolium native starches below the gelatinization temperature
The susceptibility to enzymatic hydrolysis of starch extracted from raw roots of Canna indica, Manihot esculenta and Xanthosoma sagittifolium, grown in Bolivia, were studied below the gelatinization temperature. The granule size and amylose content were as followed: C. indica>M. esculenta>X. sagittifolium. The hydrolysis showed a rapid rate at the initial stage, followed by a progressive decrease
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor
Objective: To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model. Method: An enz
Measurements of household electricity and domestic hot water use in dwellings and the effect of different monitoring time resolution
The use of household electricity and domestic hot water has been measured for 72 apartments in an apartment building located in the south of Sweden. The measurements were carried out with samples every 6 s, a tenfold increase in resolution compared to available published data, during a measurement period of five days, in the winter season, including a weekend. The influence of the time resolution
The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest.
BACKGROUND: Brain injury is considered the main cause of death in patients who are hospitalized after cardiac arrest (CA). Induced hypothermia is recommended as neuroprotective treatment after (CA) but may affect prognostic parameters. We evaluated the effect of delayed neurological prognostication on the mode of death in hypothermia-treated CA-survivors. STUDY DESIGN: Retrospective study at a Swe
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Abstract in Uncoded languages U ranijim viktimološkim istraživanjima naglašene su jednostrane slike kategorije „žrtva“ i „zločinac“. Istraživači su isticali važnost priča i usmjerili fokus analize na priče o viktimizaciji, ali istraživači nisu analizirali poslijeratne intervjue kao arenu gdje se odigrava borba za status žrtve. Ovim člankom pokušava se popuniti ta praznina analiziranjem priča 27 osPrevious research on victimhood often has presented a one-sided picture of the “victim” and “perpetrator”. Researchers have emphasized the importance of narratives and they have focused on narratives about victimhood, but a researcher has not analyzed post-war interviews as a competition for victimhood. This article tries to fill this gap using stories told by survivors of the Bosnian war during t
Universality and nonuniversality of mobility in heterogeneous single-file systems and Rouse chains
We study analytically the tracer particle mobility in single-file systems with distributed friction constants. Our system serves as a prototype for nonequilibrium, heterogeneous, strongly interacting Brownian systems. The long time dynamics for such a single-file setup belongs to the same universality class as the Rouse model with dissimilar beads. The friction constants are drawn from a density r
The rehabilitation plan can support clients' active engagement and facilitate the process of change - experiences from people with late effects of polio participating in a rehabilitation programme
Purpose: To explore how the rehabilitation plan influences the rehabilitation process and its outcome in people with late effects of polio participating in an individualised goal-oriented interdisciplinary rehabilitation programme. Methods: Four women and two men with late effects of polio were interviewed before rehabilitation, at discharge, and at follow-up. Data were analysed according to the c
Romberg ratio in quiet stance posturography-Test to retest reliability.
We investigated test to retest reliability and intraindividual variability of Romberg ratios in quiet stance posturography. Thirty-six healthy young adults (17 males, 19 females aged 15-38 years) were divided into 3 groups with different time-intervals between consecutive trials (20min, 3h and 24h respectively). Each group performed 5 posturography recordings in a randomized order of eyes open (EO
New routes to food gels and glasses
We describe the possibility to create solid-like protein samples whose structural and mechanical properties can be varied and tailored over an extremely large range in a very controlled way through an arrested spinodal decomposition process. We use aqueous lysozyme solutions as a model globular protein system. A combination of video microscopy, small-angle neutron and X-ray scattering and reverse
Molecular Portrait of Breast-Cancer-Derived Cell Lines Reveals Poor Similarity with Tumors.
Breast-cancer-derived cell lines are an important sample source for cancer proteomics and can be classified on the basis of transcriptomic analysis into subgroups corresponding to the molecular subtypes observed in mammary tumors. This study describes a tridimensional fractionation method that allows high sequence coverage and proteome-wide estimation of protein expression levels. This workflow ha