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Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; https://dest.bio/). This release includes 530 high-quality pooled

Artiklen analyserer, hvordan danske efterretningstjenester kan opretholde offentlig tillid i en tid præget af hybride trusler, øgede beføjelser og faldende autoritetstro. Tillid er afgørende for demokratisk legitimitet, men hemmeligholdelse og skandaler udfordrer den. Behovet for begrundet tillid baseret på indsigt frem for blind tillid fremhæves som centralt, og to væsentlige pointer diskuteres:

This article examines the fire and rescue services sector in Sweden in the period 1986–2021, and explains the timing of bureaucratic reforms using the Multiple Streams Framework (MSF). In this study, we insert institutions in MSF by employing a two-level analysis; we highlight the interactions among experts acting as policy entrepreneurs over time and during a large window of opportunity, and we s

Context. Globular clusters exhibit star-to-star chemical variations that are traceable through both photometric and spectroscopic data. While UV photometry and light-elements such as Na and O are commonly used for this purpose, the optical V versus (V-I) color magnitude diagram (CMD) is often assumed to be relatively unaffected by such inhomogeneities and is used to derive basic cluster parameters

We conceptualize a globally integrated circular economy through the notion of global circular networks (GCN) and identify the key mechanisms of circular (de-)coupling. We develop a novel conceptual framework by integrating concepts from literatures on global production networks (GPN) and the circular economy (CE). The framework combines four essential dimensions of these couplings - actors, resour

Let (Formula presented.) be a (Formula presented.) -adic analytic pro- (Formula presented.) group of dimension (Formula presented.), with lower (Formula presented.) -series (Formula presented.). We produce an approximate series which descends regularly in strata and whose terms deviate from (Formula presented.) in a uniformly bounded way. This brings to light a new set of rational invariants (Form

Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with

Context. The young β Pictoris system has been monitored with high-resolution optical spectrographs for decades. These observations have revealed strongly variable stochastic absorption in the Ca II H&K lines attributed to infalling cometary bodies. Aims. Since 2003, over 9000 HARPS observations of β Pictoris have been taken, and many of these have not yet been used for exocomet studies. We aim

Fluorescence microscopy is an effective tool for imaging biological samples, yet captured images often contain noises, including photon shot noise and camera read noise. To analyze biological samples accurately, separating background pixels from signal pixels is crucial. This would ideally be guided by the knowledge of a parameter called the Poisson parameter, 𝜆bg, representing the mean number of

Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. Objective: To examine GWG, adverse perinatal outcomes, substrate change

This study examines the determinants of environmentally responsible behavior among tourists in the heritage villages of Paveh County, Iran, through an integrated theoretical framework that synthesizes place-related psychological constructs with the Theory of Planned Behavior (TPB). Employing structural equation modeling on data collected from 443 tourists across three heritage villages (July–Novem

This paper presents a reflexive, transdisciplinary reassessment of the Nabberör boat grave, dated to the 8th century CE, on the Baltic island of Öland. The osteological material and the grave goods are carefully re-examined and recontextualised using a multiproxy approach, including new archaeological, bioarchaeological, zooarchaeological, isotopic, and aDNA analyses. The results reveal a multiple

Background/Objectives: Intraoperative frozen biopsies are essential during surgery for Hirschsprung’s disease (HD). However, this method has several limitations with the need for a faster and real-time diagnostic alternative. For this, consistent histoanatomical and morphometric differences between aganglionic and ganglionic bowel must be established. The primary objective was to compare dimension

In this paper, we investigate how adaptive time-integration strategies can be effectively combined with parallel-in-time numerical methods for solving systems of ordinary differential equations. Our focus is particularly on their influence on tolerance proportionality. We examine various grid-refinement strategies within the multigrid reduction-in-time (MGRIT) framework. Our results show that a si

The Kunming-Montréal Global Biodiversity Framework, adopted at COP15, establishes a clear mandate to mobilize funding from diverse sources to address the escalating biodiversity crisis. Despite growing awareness and commitment to biodiversity conservation, a substantial financing gap persists, hindering efforts to protect and restore ecosystems effectively. This chapter provides an in-depth examin

Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA. This study investigates CAC scores in patients with r-axSpA compared to controls without rheumatic disease and factors associated with CAC scores in r

Background: Treatment with antihypertensives in patients with advanced cancer is often continued until very late in the disease trajectory, despite a considerable risk of hypotension. Objectives: The aim of this study was to investigate the time of deprescribing of antihypertensive agents in patients with cancer receiving palliative care during their last year of life. The monitoring of blood pres

Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis

Alzheimer's disease (AD) is a neurodegenerative disease that often occurs in the elderly and is often accompanied by cognitive loss. Its main pathological features are the formation of amyloid-beta (Aβ) plaques and Tau tangles in the brain. Here, we used single-cell RNA sequencing (scRNA-seq) combined with computational cell–cell communication (CCC) analysis to systematically investigate trans