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A simple device for the detection of metabolic effects was constructed based on a conducting polymer (polypyrrole) coated with an agarose layer containing immobilised yeast cells. A galvanostatic potentiometric method was used to measure the resistance of the sensor, thus minimising interferences from fluctuations in solution conductivity. The resulting biosensor was used as a simple indicator of

Electrically conducting composite particles were manufactured consisting of a morphine-imprinted methacrylic acid-ethyleneglycoldimethacrylate copolymer interpenetrated with a polypyrrole network. The imprinted polymer was first prepared and then used as a host polymer into which pyrrole monomer was adsorbed. After partial drying of the pyrrole-saturated host polymer, an oxidant was adsorbed, when

Article about the conflicts arising around the rock group Rammstein’s use of German history in general and the Second World War and the Holocaust in particular.

MAX-III is a 700 MeV storage ring for synchrotron radiation that is being built at MAX-lab. The ring will provide radiation in the UV and IR spectral regions. The ring will have a 100 MHz RF system combined with a 500 MHz passive Landau cavity. The lattice is compact, with combined function magnets. The magnets are integrated into the girder providing for ease of alignment.

Different approaches have been used for translation of the EAT–Lancet reference diet into dietary scores that can be used to assess health and environmental impact. Our aim was to compare the different EAT–Lancet diet scores, and to estimate their associations with all-cause mortality, stroke incidence, and greenhouse gas emissions. We did a systematic review (PROSPERO, CRD42021286597) to identify

Objective: Various lifestyle factors including smoking, alcohol, physical activity, sedentary behavior, diet quality, sleep behavior, and overweight have been related to metabolic dysfunction-associated steatotic liver disease (MASLD); however, their joint impact on risk of MASLD is not well known. We prospectively investigated the association between a combination of lifestyle factors and risk of

Enzymatic condensation between amino acids and monosaccharides was studied. A screening involving the OH-containing amino acids serine and threonine and the monosaccharide substrates for the enzymes α-N-acetylgalactosaminidase, α-galactosidase, α-mannosidase, β-xylosidase, and β-galactosidase was carried out. Enzymatic condensation was observed with α-mannosidase and α-N-acetylgalactosaminidase. P

New methods and applications in the separation of biomolecules are reviewed, with an emphasis on the large-scale recovery of proteins. Highlights include the advent of flow-through particles in perfusion chromatography, which allows for very high flow rates, while retaining a high chromatographic efficiency.

ObjectiveTo compare and evaluate early and midterm outcomes of a “no cross” novel approach with short tip vs. standard tip introducer systems for all distal components to prevent target vessel bridging stent kink or collapse during fenestrated endovascular aortic repair (FEVAR).MethodsA retrospective analysis was conducted on all patients who underwent FEVAR at a tertiary referral centre between O

Saturated heterocycles are found widely in biologically active compounds such as medicinal drugs and agrochemicals. However, boronic acid-derived building blocks for these structures have limited availability, particularly in comparison to heteroaromatic boronic acids. We report the preparation of boronic ester γ-lactams through a Cu-catalysed conjugate borylation-cyclisation protocol. Using a chi

Liskov, Rivest and Wagner laid the theoretical foundations for tweakable block ciphers (TBC). In a seminal paper, they proposed two (up to) birthday-bound secure design strategies — LRW1 and LRW2 — to convert any block cipher into a TBC. Several of the follow-up works consider cascading of LRW-type TBCs to construct beyond-the-birthday bound (BBB) secure TBCs. Landecker et al. demonstrated that ju

Objective: This study evaluated, in a Swedish setting, the cost effectiveness of fenfluramine (FFA) as an add-on to standard of care (SoC) for reducing seizure frequency in Dravet syndrome, a severe developmental epileptic encephalopathy. Methods: Cost effectiveness of FFA+SoC compared with SoC only was evaluated using a patient-level simulation model with a lifetime horizon. Patient characteristi

Despite the increasing challenges twenty-first-century societies face in accommodating older adults, many misconceptions about old age before modernity continue to exist. These are rarely expressed in ‘formal theory’ produced by academics, but rather persist in ‘lay theory’ which is anchored in collective memory and popular culture. Such taken-for-granted beliefs are nevertheless influential, firs

Lactate dehydrogenase (LDH) was recovered from a solution by affinity binding to an N6-(6-aminohexyl)-AMP-Sepharose gel. An enzyme thermistor unit was employed to continously measure the activity of the unbound LDH. The enzyme activity signal from the enzyme thermistor was used in a PID controller to regulate the addition of AMP-Sepharose gel to the LDH solution. In another type of experiment, a d

On-line monitoring of chromatographic procedures involving biomolecules is usually restricted to UV registration and determination of the pH or conductivity of the mobile phase. A more specific monitoring of proteins, for instance direct identification of a special enzyme, would greatly facilitate and speed up purification. We have found that flow calorimetry, performed with an enzyme thermistor i

Magnetic aqueous two-phase separation is a new technique to speed up the separation of aqueous two-phase systems (Anal. Biochem. 1987, 167, 331–339). It is based on the addition of magnetically susceptible material (e.g. 1-μ iron oxide particles) which induces rapid phase separation when a mixed system is placed in a magnetic field. The technique has been applied to a number of two-phase systems.