It is well-known and experimentally conrmed that the mechanical re-sponse to loading of small enough structures diers from what applies to themacro-scale. This is valid for structures of linear measures at the nano-scale,typically below about 50nm. In addition to pure size eects also the crys-tallographic orientation becomes important at this scale. This study demon-strates the mechanical responseIt is well-known and experimentally conrmed that the mechanical re-sponse to loading of small enough structures diers from what applies to themacro-scale. This is valid for structures of linear measures at the nano-scale,typically below about 50nm. In addition to pure size eects also the crys-tallographic orientation becomes important at this scale. This study demon-strates the mechanical response

Plants can assimilate nitrogen from soil pools of both ammonium and nitrate, and the relative levels of these two nitrogen sources are highly variable in soil. Long-term ammonium nutrition is known to cause damage to Arabidopsis that has been linked to mitochondrial oxidative stress. Using hydroponic cultures, we analysed the consequences of rapid shifts between nitrate and ammonium nutrition. Thi

We introduce an axiomatization for the coalgebraic fixed point logic which was introduced by Venema as a generalization, based on Moss' coalgebraic modality, of the well-known modal mucalculus. Our axiomatization can be seen as a generalization of Kozen's proof system for the modal mu-calculus to the coalgebraic level of generality. It consists of a complete axiomatization for Moss' modality, exte

Purpose: To report a family affected by familial exudative vitreoretinopathy (FEVR) in which more severe disease phenotypes segregated with digenic rather than monogenic variants in FEVR-related genes. Methods: Phenotype was documented with high-resolution imaging of retinal structure and wide-field fundus photography. Next-generation sequencing (NGS) of known genes involved in FEVR was performed.

In Europe postgraduate training to become a geriatrician is regulated by national governments. To gain some insight how these regulations work in practice students of the Xth EAMA Postgraduate Course in Geriatrics prepared a presentation on how to become a geriatrician in their country. This article summarizes and compares the given information of 16 European countries illustrating an extensive di

The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.

The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.

The HOPS tethering complex facilitates autophagosome-lysosome fusion by binding to Syx17 (Syntaxin 17), the autophagosomal SNARE. Here we show that loss of the core HOPS complex subunit Vps16A enhances autophagosome formation and slows down Drosophila development. Mechanistically, Tor kinase is less active in Vps16A mutants likely due to impaired endocytic and biosynthetic transport to the lysosom

Homotypic fusion and vacuole protein sorting (HOPS) is a tethering complex required for trafficking to the vacuole/lysosome in yeast. Specific interaction of HOPS with certain SNARE (soluble NSF attachment protein receptor) proteins ensures the fusion of appropriate vesicles. HOPS function is less well characterized in metazoans. We show that all six HOPS subunits (Vps11 [vacuolar protein sorting

This study explored the application of localized electric fields for reversible directed self-assembly of colloidal particles in 3 dimensions. Electric field microgradients, arising from the use of micro-patterned electrodes, were utilized to direct the localization and self-assembly of polarizable (charged) particles resulting from a combination of dielectrophoretic and multipolar forces. Deioniz

The self-assembly of a mannose-labelled bile salt derivative gives rise to a metastable nematic phase of monodisperse nanotubes in aqueous solutions that are characterized by a crystalline order. This work is addressed to study the relative stability of these tubular aggregates in order to have full control of such a system for possible applications. By using a static light scattering method we ev

A novel electron deficient 4,6-bis(trifluoromethyl)-1,3-phenylene diphosphinite ligand 4 was developed and synthesized. Reaction of Ir precursors with ligand 4 gave chloro(hydride) pincer complex 5, which demonstrated a higher TON in alkane dehydrogenation reactions compared to similar phosphinite based pre-catalysts. The formation of cyclooctene (COE) and tert-butylethylene adducts of the 14e cat

The focus of this paper is on investigating the influence of skewing on the torque production of an Interior Permanent Magnet Synchronous Machine (IPMSM). The machine is designed as a traction machine according to the requirements of a parallel hybrid electric commercial heavy vehicle. In order to meet the requirements, the machine is designed with a speed higher than that of the conventional powe

The topic of this paper is the role of benchmarking in Chinese e-government. Through content analysis of documentary material, this paper addresses the following questions: Which benchmarking schemes have been applied to e-government in China? What are the intentions behind the different benchmarking schemes? and Whose interests are served? Whereas previous research finds that benchmarking address