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Association of HTR2A Polymorphisms With Chronic Widespread Pain and the Extent of Musculoskeletal Pain

Objective. The aim of the current study was to investigate whether genetic variation in genes across the serotoninergic system is associated with chronic widespread pain (CWP) and the number of pain sites reported. Methods. A discovery cohort, with pain data at 3 time points, was used to investigate genetic associations with 2 phenotypes: 1) CWP (at >= 2 time points; n = 164) compared with pain-fr

Development of functional impairment and disability in rheumatoid arthritis patients followed for 20 years - relation to disease activity, joint damage and comorbidity.

Objectives. To study the course of impairment measured by signals of functional impairment (SOFI) and disability measured by health assessment questionnaire (HAQ) over 20 years in rheumatoid arthritis (RA) patients followed from diagnosis. To explore the contribution of disease activity, joint damage and comorbidity to variation of SOFI and HAQ over time. Methods. RA patients diagnosed 1985-1989 w

Bumblebees measure optic flow for position and speed control flexibly within the frontal visual field.

When flying through narrow spaces, insects control their position by balancing the magnitude of apparent image motion (optic flow) experienced in each eye and their speed by holding this value about a desired set-point. Previously, it has been shown that when bumblebees encounter sudden changes in the proximity to nearby surfaces - as indicated by a change in the magnitude of optic flow on each si

Controlled, cross-sectional MRI evaluation of joint status in severe haemophilia A patients treated with prophylaxis vs. on demand

In patients with haemophilia A, factor VIII (FVIII) prophylaxis reduces bleeding frequency and joint damage compared with on-demand therapy. To assess the effect of prophylaxis initiation age, magnetic resonance imaging (MRI) was used to evaluate bone and cartilage damage in patients with severe haemophilia A. In this cross-sectional, multinational investigation, patients aged 12-35years were assi

Compensation for wind drift by migrating swifts

We investigated the orientation in relation to wind of common swifts, Apus apus, during nocturnal spring and autumn migration. Swifts are highly adapted to a life in the air, showing wind-dependent orientation during nocturnal roosting flights, and may be expected to be more efficient in their wind drift/compensation behaviour than nocturnal passerine migrants, which are usually subjected to full

The unique structure of Haemophilus influenzae protein E reveals multiple binding sites for host factors.

Haemophilus influenzae protein E (PE) is a multifunctional adhesin, involved in direct interactions with lung epithelial cells and host proteins, including plasminogen and the extracellular matrix proteins vitronectin and laminin. We recently crystallized PE and successfully collected X-ray diffraction data to 1.8 Å. Here we solved the structure of a recombinant version of PE and analyzed differen

Thin InAs membranes and GaSb buffer layers on GaAs(001) substrates

Thin InAs layers and membranes are fabricated on GaAs substrates using GaSb buffer layers grown by MOVPE. The quality of the GaSb buffer layers is optimized and epitaxial InAs layers are grown on GaSb layers of various thickness. The best GaSb buffer layers are obtained for a nucleation temperature of 450 degrees C and a subsequent growth temperature of 570 degrees C with a V/III ratio of 3, as co

Children with Atopic Dermatitis Should Always be Patch-tested if They Have Hand or Foot Dermatitis.

In industrialised countries atopic dermatitis (AD) is the most common chronic inflammatory disease among children. Many factors influence this disease in a negative way and contact allergy is one such factor. The aim of the study was to examine the frequency of contact allergy among children with the diagnosis AD in Malmö, Sweden and to evaluate if a significant degree of contact allergies in thes

Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau

OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged = 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects dur

Paleomagnetic and geochronological studies on Paleoproterozoic diabase dykes of Karelia, East Finland-Key for testing the Superia supercraton

Paleomagnetic results are presented for two Paleoproterozoic mafic dykes in the Taivalkoski area in northern Karelia Province of the Fennoscandian shield where, based on K-Ar data, the crust has seen minimal effects of the otherwise pervasive 1.8-1.9 Ga Svecofennian orogeny. Within this study a new U-Pb baddeleyite age of 2339 +/- 18 Ma has been determined for one of the E-W trending dykes (dyke A

Pure rotational CARS measurements of temperature and O2-concentration in a low swirl turbulent premixed flame

Abstract in UndeterminedTemperature and relative O-2-concentrations have been measured using pure rotational coherent anti-Stokes Raman spectroscopy (RCARS) in a low swirl turbulent premixed flame. This lean flame burning methane has previously been investigated using laser diagnostic techniques and numerical modeling of flame characteristics. In the present work, single-shot RCARS measurements we

Improved design of proton source and low energy beam transport line for European Spallation Source.

The design update of the European Spallation Source (ESS) accelerator is almost complete and the construction of the prototype of the microwave discharge ion source able to provide a proton beam current larger than 70 mA to the 3.6 MeV Radio Frequency Quadrupole (RFQ) started. The source named PS-ESS (Proton Source for ESS) was designed with a flexible magnetic system and an extraction system able

Training activities on radiation protection in nuclear medicine in the frame of the EURATOM FP7 collaborative project MADEIRA

MADEIRA was a Collaborative Project cofunded by the European Commission through the EURATOM Seventh Research Framework Programme. It was structured into four scientific work packages, and its aim was to optimize the efficacy and safety of 3D functional imaging in nuclear medicine and thereby to reduce the radiation exposures of the patients while keeping or even improving the quality of the diagno

Legislating a Woman's Seat on the Board: Institutional Factors Driving Gender Quotas for Boards of Directors

Ten countries have established quotas for female representation on publicly traded corporate and/or state-owned enterprise boards of directors, ranging from 33 to 50 %, with various sanctions. Fifteen other countries have introduced non-binding gender quotas in their corporate governance codes enforcing a "comply or explain" principle. Countless other countries' leaders and policy groups are in th

Parental separation in childhood, social capital, and suicide thoughts and suicide attempts: A population-based study.

Studies of the association between parental separation in childhood and suicide thoughts and attempts are scarce. The aim of this study is to investigate associations between parental separation/divorce during childhood, and ever having had suicide thoughts and ever having made suicide attempt, adjusting for social capital and other covariates. In 2012 a cross-sectional public health survey was co

Need for improvements in physical pretreatment of source-separated household food waste.

The aim of the present study was to investigate the efficiency in physical pretreatment processes of source-separated solid organic household waste. The investigation of seventeen Swedish full-scale pretreatment facilities, currently receiving separately collected food waste from household for subsequent anaerobic digestion, shows that problems with the quality of produced biomass and high mainten