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Protection of the endothelium is provided by circulating sphingosine-1-phosphate(S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did not. Moreover, HDL in Apom(-/-) mice contains no S1P, whereas HDL in transgenic mice overexpressing h
Elaidic acid is the main unnatural trans fatty acid isomer occurring during partial hydrogenation of vegetable oils used as ingredients for the formulation of processed foods. The main objective is to assess associations between processed food intakes and plasma phospholipid elaidic acid concentrations within the European Prospective Investigation into Cancer and Nutrition study. A cross-sectional
Technological advancements in mobile computing and wireless networks open up to new applications and new user-groups in the mobile workforce However, a considerable part of the mobile workforce, such as e g drivers or healthcare staff, is chiefly performing other tasks than interacting with their computers As a result. they are not able to pay attention to computer interaction, making them mainly
To study micturition and bladder overactivity in female rats after chronic treatment with the fatty acid amide hydrolase (FAAH) inhibitor oleoyl ethyl amide (OEtA).
The well-known O(n^2) minmax cost algorithm of Lawler (MANAGE SCI 19(5):544–546, 1973) was developed to minimize the maximum cost of jobs processed by a single machine under precedence constraints. We propose two results related to Lawler’s algorithm. Lawler’s algorithm delivers one specific optimal schedule while there can exist other optimal schedules. We present necessary and sufficient conditi
Background: Serial transverse enteroplasty (STEP) was first described in 2003 as a method for lengthening and tapering of the bowel in short bowel syndrome. The aim of this multicentre study was to review the outcome of a Swedish cohort of children who underwent STEP. Methods: All children who had a STEP procedure at one of the four centres of paediatric surgery in Sweden between September 2005 an
Although bacteria are unicellular organisms, they have the ability to act in concert by synthesizing and detecting small diffusing autoinducer molecules. The phenomenon, known as quorum sensing, has mainly been proposed to serve as a means for cell-density measurement. Here, we use a cell-based model of growing bacterial microcolonies to investigate a quorum-sensing mechanism at a single cell leve
The objective of this paper was to address the importance of dealing systematically and comprehensively with uncertainty in a budget impact analysis (BIA) in more detail. The handling of uncertainty in health economics was used as a point of reference for addressing the uncertainty in a BIA. This overview shows that standard methods of sensitivity analysis, which are used for standard data set in
A simple technique is described to functionalize a small library of microcantilever (MC) chips presenting varied headgroups. A generic azide monolayer, bound to the MC surface, can be coupled with various alkynes using efficient "click" chemistry. This method is compatible with many functional groups, and novel headgroups are introduced on the MC surface by means of alkynes synthesized via a one-s
Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) in aqua is present in the European baseline patch test series at 100 ppm, whereas 200 ppm has been used in Sweden since 1986, in Spain in the late 1980s, and, in recent years, also in the United Kingdom and Ireland.
Optogenetic tools comprise a variety of different light-sensitive proteins from single-cell organisms that can be expressed in mammalian neurons and effectively control their excitability. Two main classes of optogenetic tools allow to either depolarize or hyperpolarize, and respectively generate or inhibit action potentials in selective populations of neurons. This opens unprecedented possibiliti
The combination of nanoparticles and polymers into nanocomposite gels has been shown to be a promising route to creating soft materials with new or improved properties. In the present work, we have made use of Laponite nanoparticles in combination with a poly(N-isopropylacrylamide) (PNIPAAM)polymer and describe a phenomenon taking place during the polymerization and gelling of this system. The pre
Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment is associated with the development of potentially disabling motor complications. Experimental studies suggest that motor complications are due to non-physiological, intermittent administration of the drug, and can be reduced with continuous delivery. We aimed to assess efficacy and safety of levodopa-carbidopa in
The main aims were to explore time trends in the management and outcome of patients with rectal cancer in a national cohort and to evaluate the possible impact of national auditing on overall outcomes. A secondary aim was to provide population-based data for appraisal of external validity in selected patient series.
Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) part
The current study investigated if and how students' behaviour when using a teachable agent-based educational software were related to their working memory capacity. Thirty Swedish students aged 11-12, participated in the study. Results showed that differences in behaviour such as time spent on an off-task activity, time spent on interactive dialogues, and the number of tests that students let thei
Lignocellulose is widely recognized as a Sustainable substrate for biofuels production, and the enzymatic hydrolysis is regarded as a critical step for the development of ail effective process for the conversion of cellulose into ethanol. One key factor affecting the overall conversion rate is the adsorption capacity of the cellulase enzymes to the surface of the insoluble substrate. Pretreatment
Using in situ surface-sensitive electron microscopy performed in real time, we show that the dynamics of micron-sized Ga droplets on Ga P(111) can be manipulated locally using Au nanoparticles. Detailed measurements of structure and dynamics of the surface from microns to atomic scale are done using both surface electron and scanning probe microscopies. Imaging is done simultaneously on areas with
Food production and consumption have a range of sustainability implications, including their contribution to global emissions of greenhouse gases (GHGs). As some foodstuffs entail higher GHG emissions than others, managing their use in tourism-related contexts could make a significant contribution to climate change mitigation. This article reviews the carbon intensity of selected foods and discuss
Cyclooxygenase-2 (COX-2) is an enzyme that has been extensively investigated as a prognostic marker in cancer. In non-small cell lung cancer (NSCLC) previous results regarding the prognostic impact of COX-2 expression are inconsistent. Therefore we evaluated the association between transcript levels and overall survival in nine publicly available gene expression data sets (total n = 1337) and dete
