A research-based understanding of permafrost distribution at a sufficient spatial resolution is important to meet the demands of science, education and society. We present a new permafrost map for Norway, Sweden and Finland that provides a more detailed and updated description of permafrost distribution in this area than previously available. We implemented the CryoGRID1 model at 1km2 resolution,

Nocturnal dung beetles (Scarabaeus satyrus) are currently the only animals that have been demonstrated to use the Milky Way for reliable orientation. In this study, we tested the capacity of S. satyrus to orient under a range of artificial celestial cues, and compared the properties of these cues with images of the Milky Way simulated for a beetle’s visual system. We find that the mechanism that p

Night vision is ultimately about extracting information from a noisy visual input. Several species of nocturnal insects exhibit complex visually guided behaviour in conditions where most animals are practically blind. The compound eyes of nocturnal insects produce strong responses to single photons and process them into meaningful neural signals, which are amplified by specialized neuroanatomical

AZD5423 is a selective glucocorticosteroid receptor modulator developed for the inhaled use in asthma and COPD. This study reports the initial, first-in-man, single and repeat dose-escalating studies in healthy male individuals, including one cohort of male Japanese individuals. Inhaled, nebulized AZD5423 was safe and well tolerated up to and including the highest doses tested for up to 2 weeks of

This article demonstrates that typical restrictions which are imposed in dialogical logic in order to recover first-order logical consequence from a fragment of natural language argumentation are also forthcoming from preference profiles of boundedly rational players, provided that these players instantiate a specific player type and compute partial strategies. We present two structural rules, whi

Background and purpose — Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of

Introduction Clinical trials in Alzheimer's disease are aimed at early stages of disease, including preclinical Alzheimer's disease. The high cost and time required to screen large numbers of participants for Aβ pathology impede the development of novel drugs. This study's objective was to evaluate the extent to which inexpensive and easily obtainable information can reduce the number of screen fa

Perturbation problems for operators with embedded eigenvalues are generally challenging since the embedded eigenvalues cannot be separated from the rest of the spectrum. In this paper, we study a perturbation problem for embedded eigenvalues for a magnetic Schrödinger operator, when the underlying domain is a cylinder. The magnetic potential is C2 with an algebraic decay rate as the unbounded vari

We present a biologically inspired model for estimating the position of a moving target that is invariant to the target's contrast. Our model produces a monotonic relationship between position and output activity using a divisive normalization between the 'receptive fields' of two overlapping, wide-field, small-target motion detector (STMD) neurons. These visual neurons found in flying insects, li

This paper presents a comprehensive study of sectoral co-movements of employment growth in the entire Dutch economy. We construct different macro typologies according to manufacturing versus services, innovativeness, labour skills and position in the value chain, thus expanding the list of potential logics of sectoral interrelations. Using a vector autoregression model, we assess whether and how g

A small vacuum chamber aperture is a present trend in the design of future synchrotron light sources. This leads to a large resistive-wall impedance that can drive coupled-bunch instabilities. Another trend is the use of passively driven cavities at a harmonic of the main radio frequency to lengthen the electron bunches in order to increase the Touschek lifetime and reduce emittance blowup due to

Alternative fuels have been proposed as a means for future energy-secure and environmentally sustainable transportation. This review and benchmarking show that several of the alternative fuels (e.g. methanol, ethanol, higher alcohols, RME, HVO, DME, and biogas/CNG) work well with several different engine concepts such as conventional SI, DICI, and dual fuel, and with the emerging concepts HCCI, RC

Eukaryotic-especially human-membrane protein overproduction remains a major challenge in biochemistry. Heterologously overproduced and purified proteins provide a starting point for further biochemical, biophysical and structural studies, and the lack of sufficient quantities of functional membrane proteins is frequently a bottleneck hindering this. Here, we report exceptionally high production le

The chapter discusses the spatial aspects of the increased globalization of innovation, analysing both the region’s role in influencing the propensity of actors to engage and to play different roles in global innovation networks (GINs). Until now, different concepts such as global value chain (GVC), global production network (GPN) and GIN have been used to explain the increase globalization of inn